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Original Article

Efficacy and safety of mavrilimumab in Japanese subjects with rheumatoid arthritis: Findings from a Phase IIa study

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Pages 21-30 | Received 17 Dec 2013, Accepted 16 Feb 2014, Published online: 11 Apr 2014

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Chiara Crotti, Martina Biggioggero, Andrea Becciolini, Elena Agape & Ennio Giulio Favalli. (2019) Mavrilimumab: a unique insight and update on the current status in the treatment of rheumatoid arthritis. Expert Opinion on Investigational Drugs 28:7, pages 573-581.
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Chiara Crotti, Maria Gabriella Raimondo, Andrea Becciolini, Martina Biggioggero & Ennio Giulio Favalli. (2017) Spotlight on mavrilimumab for the treatment of rheumatoid arthritis: evidence to date. Drug Design, Development and Therapy 11, pages 211-223.
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Xiujuan Wu, Juan Wang, Kangding Liu, Jie Zhu & Hong-Liang Zhang. (2016) Are Th17 cells and their cytokines a therapeutic target in Guillain–Barré syndrome?. Expert Opinion on Therapeutic Targets 20:2, pages 209-222.
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Samra Sardar & Åsa Andersson. (2016) Old and new therapeutics for Rheumatoid Arthritis: in vivo models and drug development. Immunopharmacology and Immunotoxicology 38:1, pages 2-13.
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Mahdi Alahgholi-Hajibehzad, Pinar Kasapoglu, Reza Jafari & Nima Rezaei. (2015) The role of T regulatory cells in immunopathogenesis of myasthenia gravis: implications for therapeutics. Expert Review of Clinical Immunology 11:7, pages 859-870.
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Articles from other publishers (28)

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Kinal Bhatt, Radhika Garimella, Rahima Taugir, Isha Mehta, Muhammad Jamal, Rupalakshmi Vijayan, Rita Offor, Kanayo Nwankwo, Uroosa Arif, Khurram Waheed, Priyanka Kumari, Maulik Lathiya, George Michel, Naushira Pandya, John Halpern, Hassan Nasir & Marcos A. Sanchez-Gonzalez. (2021) Effectiveness of Mavrilimumab in Viral Infections Including SARS-CoV-2 Infection - A Brief Review. Infection & Chemotherapy 53:1, pages 1.
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Xuezhi Yang, Yan Chang & Wei Wei. (2020) Emerging role of targeting macrophages in rheumatoid arthritis: Focus on polarization, metabolism and apoptosis. Cell Proliferation 53:7.
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Andreas Kerschbaumer, Josef S. Smolen, Harald Herkner, Tijen Stefanova, Eva Chwala & Daniel Aletaha. (2020) Efficacy outcomes in phase 2 and phase 3 randomized controlled trials in rheumatology. Nature Medicine 26:6, pages 974-980.
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Kota Nagai, Keisuke Matsubayashi, Kazuki Ide, Kahori Seto, Yohei Kawasaki & Koji Kawakami. (2020) Factors Influencing Placebo Responses in Rheumatoid Arthritis Clinical Trials: A Meta-Analysis of Randomized, Double-Blind, Placebo-Controlled Studies. Clinical Drug Investigation 40:3, pages 197-209.
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John A. Hamilton. (2020) GM-CSF in inflammation. Journal of Experimental Medicine 217:1.
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M. Reza Khorramizadeh & Farshid Saadat. 2020. Animal Biotechnology. Animal Biotechnology 153 171 .
Peter C. Taylor, Didier Saurigny, Jiri Vencovsky, Tsutomu Takeuchi, Tadashi Nakamura, Galina Matsievskaia, Barbara Hunt, Thomas Wagner & Bernard Souberbielle. (2019) Efficacy and safety of namilumab, a human monoclonal antibody against granulocyte-macrophage colony-stimulating factor (GM-CSF) ligand in patients with rheumatoid arthritis (RA) with either an inadequate response to background methotrexate therapy or an inadequate response or intolerance to an anti-TNF (tumour necrosis factor) biologic therapy: a randomized, controlled trial. Arthritis Research & Therapy 21:1.
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Chiara Crotti, Elena Agape, Andrea Becciolini, Martina Biggioggero & Ennio Giulio Favalli. (2019) Targeting Granulocyte-Monocyte Colony-Stimulating Factor Signaling in Rheumatoid Arthritis: Future Prospects. Drugs 79:16, pages 1741-1755.
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S Alivernini, B Tolusso, G Ferraccioli, E Gremese, M Kurowska-Stolarska & I B McInnes. (2018) Driving chronicity in rheumatoid arthritis: perpetuating role of myeloid cells. Clinical and Experimental Immunology 193:1, pages 13-23.
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Andrew D. Cook & John A. Hamilton. (2018) Investigational therapies targeting the granulocyte macrophage colony-stimulating factor receptor-α in rheumatoid arthritis: focus on mavrilimumab. Therapeutic Advances in Musculoskeletal Disease 10:2, pages 29-38.
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T. W. J. Huizinga, A. Batalov, R. Stoilov, E. Lloyd, T. Wagner, D. Saurigny, B. Souberbielle & E. Esfandiari. (2017) Phase 1b randomized, double-blind study of namilumab, an anti-granulocyte macrophage colony-stimulating factor monoclonal antibody, in mild-to-moderate rheumatoid arthritis. Arthritis Research & Therapy 19:1.
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Gerd R Burmester, Iain B McInnes, Joel Kremer, Pedro Miranda, Mariusz Korkosz, Jiri Vencovsky, Andrea Rubbert-Roth, Eduardo Mysler, Matthew A Sleeman, Alex Godwood, Dominic Sinibaldi, Xiang Guo, Wendy I White, Bing Wang, Chi-Yuan Wu, Patricia C Ryan, David Close & Michael E Weinblatt. (2017) A randomised phase IIb study of mavrilimumab, a novel GM–CSF receptor alpha monoclonal antibody, in the treatment of rheumatoid arthritis. Annals of the Rheumatic Diseases 76:6, pages 1020-1030.
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Helen L Wright, Trevor Cox, Robert J Moots & Steven W Edwards. (2017) Neutrophil biomarkers predict response to therapy with tumor necrosis factor inhibitors in rheumatoid arthritis. Journal of Leukocyte Biology 101:3, pages 785-795.
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Santos Castañeda & Isidoro González-Álvaro. (2017) Innovations in the therapeutic outlook of rheumatoid arthritis. Reumatología Clínica (English Edition) 13:2, pages 63-65.
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Santos Castañeda & Isidoro González-Álvaro. (2017) Novedades en el panorama terapéutico de la artritis reumatoide. Reumatología Clínica 13:2, pages 63-65.
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John A. Hamilton, Andrew D. Cook & Paul P. Tak. (2016) Anti-colony-stimulating factor therapies for inflammatory and autoimmune diseases. Nature Reviews Drug Discovery 16:1, pages 53-70.
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Irina Ushach & Albert Zlotnik. (2016) Biological role of granulocyte macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) on cells of the myeloid lineage. Journal of Leukocyte Biology 100:3, pages 481-489.
Crossref
J. R. Kalden. (2016) BiologikaBiologics. Zeitschrift für Rheumatologie 75:6, pages 604-610.
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Joachim. R. Kalden. (2016) Emerging Therapies for Rheumatoid Arthritis. Rheumatology and Therapy 3:1, pages 31-42.
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Ian P. Wicks & Andrew W. Roberts. (2015) Targeting GM-CSF in inflammatory diseases. Nature Reviews Rheumatology 12:1, pages 37-48.
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A. Berkant Avci, Eugen Feist & Gerd-R. Burmester. (2015) A Promising Target in Rheumatoid Arthritis Treatment: Granulocyte-Macrophage Colony-Stimulating Factor. Current Treatment Options in Rheumatology 1:4, pages 320-333.
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