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Modern Rheumatology Volume 25, 2015 - Issue 1
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Original Article

Tocilizumab is clinically, functionally, and radiographically effective and safe either with or without low-dose methotrexate in active rheumatoid arthritis patients with inadequate responses to DMARDs and/or TNF inhibitors: A single-center retrospective cohort study (KEIO-TCZ study) at week 52

Keisuke IzumiDivision of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, JapanCorrespondence[email protected]
,
Yuko KanekoDivision of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
,
Hidekata YasuokaDivision of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
,
Noriyuki SetaDivision of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
,
Hideto KamedaDivision of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan;Division of Rheumatology, Department of Internal Medicine, School of Medicine, Toho University, Tokyo, Japan
,
Masataka KuwanaDivision of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
&
Tsutomu TakeuchiDivision of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
 show all
Pages 31-37 | Received 13 Nov 2013, Accepted 21 Feb 2014, Published online: 01 Apr 2014

Citations (15)

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Kyosuke Hattori, Yuji Hirano, Yasuhide Kanayama, Yosuke Hattori, Takefumi Kato, Nobunori Takahashi, Naoki Ishiguro & Toshihisa Kojima. (2021) Efficacy of add-on iguratimod in patients with rheumatoid arthritis who inadequately respond to either tocilizumab or tumor necrosis factor alpha inhibitors. Modern Rheumatology 31:1, pages 80-87.
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Yasuharu Nakashima, Masakazu Kondo, Eisuke Shono, Takashi Ishinishi, Hiroshi Tsukamoto, Koji Kuroda, Akira Maeyama, Hiroshi Harada, Masayuki Maekawa, Takashi Shimauchi, Ryuji Nagamine, Hiroshi Jojima, Seiji Yoshizawa, Tomomi Tsuru, Takeshi Otsuka, Hisaaki Miyahara, Eiichi Suematsu, Ken Wada, Shigeru Yoshizawa, Yasushi Inoue, Takaaki Fukuda, Satoshi Ikemura & Akihisa Haraguchi. (2020) Suppression of joint destruction with subcutaneous tocilizumab for Japanese patients with rheumatoid arthritis in clinical practice. Modern Rheumatology 30:5, pages 807-815.
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Kosuke Ebina, Akira Miyama, Hideki Tsuboi, Shoichi Kaneshiro, Masataka Nishikawa, Hajime Owaki, Shigeyoshi Tsuji, Makoto Hirao, Yuki Etani, Atsushi Goshima, Jun Hashimoto & Hideki Yoshikawa. (2019) The add-on effectiveness and safety of iguratimod in patients with rheumatoid arthritis who showed an inadequate response to tocilizumab. Modern Rheumatology 29:4, pages 581-588.
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Katsuhiko Takabayashi, Fumihiko Ando & Takahiro Suzuki. (2019) Comparing the effectiveness of biological disease-modifying antirheumatic drugs using real-world data. Modern Rheumatology 29:1, pages 87-97.
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Shoichi Kaneshiro, Kosuke Ebina, Makoto Hirao, Hideki Tsuboi, Masataka Nishikawa, Akihide Nampei, Yoshio Nagayama, Koichiro Takahi, Takaaki Noguchi, Hajime Owaki, Jun Hashimoto & Hideki Yoshikawa. (2017) The efficacy and safety of additional administration of tacrolimus in patients with rheumatoid arthritis who showed an inadequate response to tocilizumab. Modern Rheumatology 27:1, pages 42-49.
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Articles from other publishers (10)

Akira Hashimoto, Motoki Sonohata & Masaaki Mawatari. (2020) The Use of Oral Analgesics and Pain Self-Efficacy Are Independent Predictors of the Quality of Life of Individuals with Rheumatoid Arthritis. Pain Research and Management 2020, pages 1-9.
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Naoki Kondo, Junichi Fujisawa & Naoto Endo. (2020) Subcutaneous Tocilizumab Is Effective for Treatment of Elderly-Onset Rheumatoid Arthritis. The Tohoku Journal of Experimental Medicine 251:1, pages 9-18.
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Amany El-Shahawy Abdel-Maged, Amany M. Gad, Amal Kamal Abdel-Aziz, Mohammad M. Aboulwafa & Samar S. Azab. (2018) Comparative study of anti-VEGF Ranibizumab and Interleukin-6 receptor antagonist Tocilizumab in Adjuvant-induced Arthritis. Toxicology and Applied Pharmacology 356, pages 65-75.
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Gablu Kilcher, Noemi Hummel, Eva M Didden, Matthias Egger & Stephan Reichenbach. (2018) Rheumatoid arthritis patients treated in trial and real world settings: comparison of randomized trials with registries. Rheumatology 57:2, pages 354-369.
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Yusuke Miwa, Mayu Saito, Hidekazu Furuya, Ryo Yanai & Tsuyoshi Kasama. (2017) Predictor of the Simplified Disease Activity Index 50 (SDAI 50) at Month 3 of bDMARD Treatment in Patients with Long-Established Rheumatoid Arthritis. The Open Rheumatology Journal 11:1, pages 106-112.
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Mari Kihara, Rebecca Davies, Lianne Kearsley-Fleet, Kath D. Watson, Mark Lunt, Deborah P.M. Symmons & Kimme L. Hyrich. (2016) Use and effectiveness of tocilizumab among patients with rheumatoid arthritis: an observational study from the British Society for Rheumatology Biologics Register for rheumatoid arthritis. Clinical Rheumatology 36:2, pages 241-250.
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Yusuke Miwa, Mayu Saito, Hidekazu Furuya, Ryo Yanai, Yuzo Ikari, Tomoki Hayashi, Tsuyoshi Kasama, Yoichi Toyoshima & Katsunori Inagaki. (2017) Clinical Characteristics of Rheumatoid Arthritis Patients Achieving Functional Remission after Six Months of Non-tumor Necrosis Factor Biological Disease-Modifying Antirheumatic Drugs (DMARDs) Treatment. Internal Medicine 56:17, pages 2271-2275.
Crossref
Yusuke Miwa, Ryo Takahashi, Yuzo Ikari, Airi Maeoka, Shinichiro Nishimi, Nao Oguro, Tomoki Hayashi, Mika Hatano, Sakiko Isojima, Ryo Yanai, Tsuyoshi Kasama, Yoichi Toyoshima, Katsunori Inagaki & Kenji Sanada. (2017) Clinical Characteristics of Rheumatoid Arthritis Patients Achieving Functional Remission with Six Months of Biological DMARDs Treatment. Internal Medicine 56:8, pages 903-906.
Crossref
Mitsuhiro Akiyama, Yuko Kaneko, Kunihiro Yamaoka, Harumi Kondo & Tsutomu Takeuchi. (2016) Association of disease activity with acute exacerbation of interstitial lung disease during tocilizumab treatment in patients with rheumatoid arthritis: a retrospective, case–control study. Rheumatology International 36:6, pages 881-889.
Crossref
Keisuke Izumi, Yuko Kaneko, Misato Hashizume, Keiko Yoshimoto & Tsutomu Takeuchi. (2015) Baseline Serum Osteopontin Levels Predict the Clinical Effectiveness of Tocilizumab but Not Infliximab in Biologic-Naïve Patients with Rheumatoid Arthritis: A Single-Center Prospective Study at 1 Year (the Keio First-Bio Cohort Study). PLOS ONE 10:12, pages e0145468.
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