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Case Report

TAFRO syndrome successfully treated with tocilizumab: A case report and systematic review

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Pages 564-569 | Received 17 Aug 2015, Accepted 12 Nov 2015, Published online: 17 Feb 2016

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Risa Wakiya, Tomohiro Kameda, Yohei Takeuchi, Hiroki Ozaki, Shusaku Nakashima, Hiromi Shimada, Norimitsu Kadowaki & Hiroaki Dobashi. (2021) Sequential change in serum VEGF levels in a case of tocilizumab-resistant TAFRO syndrome treated effectively with rituximab. Modern Rheumatology Case Reports 5:1, pages 145-151.
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Gen Nakamura, Noriyuki Homma, Akio Kasai, Takuya Kasami, Kunihiko Makino, Youhei Aoki, Kunihiko Wakaki & Norihito Nakagawa. (2019) Magnetic resonance imaging of bone marrow for TAFRO syndrome. Modern Rheumatology 29:3, pages 551-557.
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Matthew B. Carroll. (2018) Tocilizumab in the treatment of myocardial infarction. Modern Rheumatology 28:5, pages 733-735.
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Articles from other publishers (20)

Tingting Chen, Chun Feng, Xinyou Zhang & Jihao Zhou. (2022) TAFRO syndrome: A disease that known is half cured. Hematological Oncology 41:3, pages 310-322.
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Ryuichi Ohta & Chiaki Sano. (2023) Thrombocytopenia, Anasarca, Myelofibrosis, Renal dysfunction, and Organomegaly (TAFRO) Syndrome Initially Diagnosed as Fibromyalgia: A Case Report. Cureus.
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Mitsuru Watanabe, Yoichiro Haji, Mirai Hozumi, Yui Amari, Yukina Mizuno, Takanori Ito, Mizuki Kato & Masato Okada. (2023) Combined B-cell immunomodulation with rituximab and belimumab in severe, refractory TAFRO syndrome associated with Sjögren’s syndrome: A case report. Modern Rheumatology Case Reports 7:2, pages 475-479.
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Keiko Yamagami, Yusuke Hanioka, Shuhei Yao, Ryota Nakamura, Tomoyuki Nakamura, Naomi Ishii & Hitoshi Goto. (2023) A case of TAFRO syndrome maintained in remission for 5 years after discontinuation of tocilizumab. Modern Rheumatology Case Reports 7:1, pages 205-210.
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Germán Puerta, David De Paz, David Aguirre-Valencia, Fabián Ahumada, Nhora Silva, Juan C. Bravo & Alex Echeverri. (2022) TAFRO syndrome mimicking systemic lupus erythematosus: Case report and literature review. Revista Colombiana de Reumatología (English Edition) 29:4, pages 373-383.
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Germán Puerta, David De Paz, David Aguirre-Valencia, Fabián Ahumada, Nhora Silva, Juan C. Bravo & Alex Echeverri. (2022) TAFRO syndrome mimicking systemic lupus erythematosus: Case report and literature review. Revista Colombiana de Reumatología 29:4, pages 373-383.
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Kyosuke Yamaguchi, Yasushi Kubota, Hiroo Katsuya, Toshihiko Ando & Shinya Kimura. (2022) Post-transplant Complication With TAFRO Features in a Patient With Acute Myeloid Leukemia. Cureus.
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Yoshito Nishimura, David C. Fajgenbaum, Sheila K. Pierson, Noriko Iwaki, Asami Nishikori, Mitsuhiro Kawano, Naoya Nakamura, Koji Izutsu, Kengo Takeuchi, Midori Filiz Nishimura, Yoshinobu Maeda, Fumio Otsuka, Kazuyuki Yoshizaki, Eric Oksenhendler, Frits Rhee & Yasuharu Sato. (2021) Validated international definition of the thrombocytopenia, anasarca, fever, reticulin fibrosis, renal insufficiency, and organomegaly clinical subtype (TAFRO) of idiopathic multicentric Castleman disease . American Journal of Hematology 96:10, pages 1241-1252.
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Tomoya OkamotoShinichi OchiYuki MotokawaHidekazu AzumiShinya KobayashiFumihiko Nakamura, Toshiya NakataniHideo Yagi. (2021) Fatal case of TAFRO syndrome with unilateral adrenal hemorrhage in early-stage disease. Journal of Clinical and Experimental Hematopathology 61:2, pages 109-113.
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David C. Fajgenbaum, David Wu, Aaron Goodman, Raymond Wong, Amy Chadburn, Sunita Nasta, Gordan Srkalovic, Sudipto Mukherjee, Heather Leitch, Raj Jayanthan, Simone Ferrero, Yasuharu Sato, Steve Schey, Angela Dispenzieri, Eric Oksenhendler, Pier Luigi Zinzani, Mary Jo Lechowicz, Christian Hoffmann, Naveen Pemmaraju, Adam Bagg, Alexander Fossa, Megan S. Lim & Frits Rhee. (2020) Insufficient evidence exists to use histopathologic subtype to guide treatment of idiopathic multicentric Castleman disease. American Journal of Hematology 95:12, pages 1553-1561.
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Daichi Fukaya, Tsutomu Inoue, Yuta Kogure, Hiroshi Kajiyama, Keisuke Ishizawa, Takeru Seto, Hajime Hasegawa, Toshihide Mimura & Hirokazu Okada. (2020) Tocilizumab-induced immunocomplex glomerulonephritis: a report of two cases. CEN Case Reports 9:4, pages 318-325.
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Mitsuhiro Akiyama, Yuko Kaneko & Tsutomu Takeuchi. (2020) Tocilizumab for the treatment of TAFRO syndrome: a systematic literature review. Annals of Hematology 99:11, pages 2463-2475.
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Ryo Kurokawa, Wataru Gonoi, Hajime Yokota, Saiko Isshiki, Kenji Ohira, Hideaki Mizuno, Takao Kiguchi, Shohei Inui, Mariko Kurokawa, Shimpei Kato, Mitsuru Matsuki, Taro Takeda, Kota Yokoyama, Yoshiaki Ota, Yudai Nakai, Eriko Maeda, Harushi Mori & Osamu Abe. (2020) Computed tomography findings of early-stage TAFRO syndrome and associated adrenal abnormalities. European Radiology 30:10, pages 5588-5598.
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Soya Kobayashi, Ayano Inui, Tomoyuki Tsunoda, Syuichiro Umetsu, Tsuyoshi Sogo, Masaaki Mori, Masato Shinkai & Tomoo Fujisawa. (2020) Liver cirrhosis in a child associated with Castleman's disease: A case report. World Journal of Clinical Cases 8:9, pages 1656-1665.
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Yoshito Nishimura, Yoshihisa Hanayama, Nobuharu Fujii, Eisei Kondo & Fumio Otsuka. (2020) Comparison of the clinical characteristics of TAFRO syndrome and idiopathic multicentric Castleman disease in general internal medicine: a 6‐year retrospective study. Internal Medicine Journal 50:2, pages 184-191.
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Hirotaka Saito, Kenichi Tanaka, Momoko Fujiwara, Tsuyoshi Iwasaki, Tokutaro Numata, Akira Oda, Makoto Kanno, Mizuko Tanaka, Masaaki Eiro, Mamoru Satoh & Junichiro James Kazama. (2019) Pathological findings of progressive renal involvement in a patient with TAFRO syndrome. CEN Case Reports 8:4, pages 239-245.
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Arata Hibi, Ken Mizuguchi, Akiko Yoneyama, Takahisa Kasugai, Keisuke Kamiya, Keisuke Kamiya, Chiharu Ito, Satoru Kominato, Toshiyuki Miura & Katsushi Koyama. (2018) Severe refractory TAFRO syndrome requiring continuous renal replacement therapy complicated with Trichosporon asahii infection in the lungs and myocardial infarction: an autopsy case report and literature review. Renal Replacement Therapy 4:1.
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Fabrice Coutier, Nadine Meaux Ruault, Thomas Crepin, Kevin Bouiller, Helder Gil, Sébastien Humbert, Isabelle Bedgedjian & Nadine Magy-Bertrand. (2017) A comparison of TAFRO syndrome between Japanese and non-Japanese cases: a case report and literature review. Annals of Hematology 97:3, pages 401-407.
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Tatsuya Aoki, Mikio Wada, Atsushi Kawashima, Kouichi Hirakawa, Akihiro Nagata & Keizo Kagawa. (2017) Tocilizumab-resistant TAFRO Syndrome Complicated by Type II Respiratory Failure. Internal Medicine 56:23, pages 3249-3254.
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Hiroaki Tanaka, Satoshi Bujo, Ei Itobayashi, Akira Nakamura, Akihiro Ishii & Yoshio Suzuki. (2017) TAFRO syndrome with a rapid fatal course despite corticosteroid and tocilizumab therapy. Journal of Hematopathology 9:4, pages 167-171.
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