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Human Fertility
an international, multidisciplinary journal dedicated to furthering research and promoting good practice
Volume 18, 2015 - Issue 3
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REVIEW ARTICLE

Deleterious effects of obesity upon the hormonal and molecular mechanisms controlling spermatogenesis and male fertility

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Pages 184-193 | Received 08 Dec 2014, Accepted 14 Apr 2015, Published online: 24 Jul 2015

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Firass Abiad, Johnny Awwad, Hussein A. Abbas, Dina Zebian & Ghina Ghazeeri. (2017) Management of weight loss in obesity-associated male infertility: a spotlight on bariatric surgery. Human Fertility 20:4, pages 227-235.
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Crossref
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Crossref
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Crossref
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Ian A. Aird & Yitka Graham. 2018. Practical Guide to Obesity Medicine. Practical Guide to Obesity Medicine 123 142 .
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Crossref
Yue Liu & Zhide Ding. (2017) Obesity, a serious etiologic factor for male subfertility in modern society. Reproduction 154:4, pages R123-R131.
Crossref
Jing-Lu Zhao, Yu-Yun Zhao & Wei-Jie Zhu. (2017) A high-fat, high-protein diet attenuates the negative impact of casein-induced chronic inflammation on testicular steroidogenesis and sperm parameters in adult mice. General and Comparative Endocrinology 252, pages 48-59.
Crossref
Seyed Kazem Kazemeini, Majid Emtiazy, Fatemeh Owlia & Parisa Khani. (2017) Causes of infertility in view of Iranian traditional medicine: A review. International Journal of Reproductive BioMedicine 15:4, pages 187-194.
Crossref
Marcos Moradas Estrada. (2017) Is the Ditio-Octonoate Monomer the Ideal for Adhesion to Precious Metals and their Alloys?. International Journal of Radiology & Radiation Therapy 3:1.
Crossref
Xuejie YiHaining GaoDequan Chen, Donghui Tang, Wanting HuangTao LiTie MaBo Chang. (2017) Effects of obesity and exercise on testicular leptin signal transduction and testosterone biosynthesis in male mice. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 312:4, pages R501-R510.
Crossref
Claudia J. Bautista, Guadalupe L. Rodríguez-González, Angélica Morales, Consuelo Lomas-Soria, Fabiola Cruz-Pérez, Luis A. Reyes-Castro & Elena Zambrano. (2017) Maternal obesity in the rat impairs male offspring aging of the testicular antioxidant defence system. Reproduction, Fertility and Development 29:10, pages 1950.
Crossref
Maria Etelvina Pinto-Fochi, Eloísa Zanin Pytlowanciv, Vanessa Reame, Alex Rafacho, Daniele Lisboa Ribeiro, Sebastião Roberto Taboga & Rejane Maira Góes. (2016) A high-fat diet fed during different periods of life impairs steroidogenesis of rat Leydig cells. Reproduction 152:6, pages 795-808.
Crossref
I.V. Wagner, N. Klöting, N. Atanassova, I. Savchuk, C. Spröte, W. Kiess, O. Söder & K. Svechnikov. (2016) Prepubertal onset of obesity negatively impacts on testicular steroidogenesis in rats. Molecular and Cellular Endocrinology 437, pages 154-162.
Crossref
Xiaodan Wang, Jiayuan Hao, Fuli Zhang, Jing Li, Huijuan Kong & Yihong Guo. (2016) Effects of female and male body mass indices on the treatment outcomes and neonatal birth weights associated with in vitro fertilization/intracytoplasmic sperm injection treatment in China. Fertility and Sterility 106:2, pages 460-466.
Crossref
최진호 & 한정열. (2016) Preconception Care for Men. JOURNAL OF THE KOREAN SOCIETY OF MATERNAL AND CHILD HEALTH 20:1, pages 1-11.
Crossref
I. I. Vityazeva, M. V. Altashina, O. U. Razina, T. V. Mun, R. U. Liutyi, E. A. Troshina & I. I. Dedov. (2016) Changing of the ejaculate parameters and sperm structure in men with overweight. Problemy reproduktsii 22:6, pages 132.
Crossref

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