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Research Article

Carbonic Anhydrase Inhibitors: Synthesis of Schiff Bases of Hydroxybenzaldehydes with Aromatic Sulfonamides and Their Reactions with Arylsulfonyl Isocyanates

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Pages 533-546 | Received 18 Jan 2000, Published online: 27 Sep 2008

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Read on this site (5)

Namrata Singasane, Prashant S. Kharkar, Mariangela Ceruso, Claudiu T. Supuran & Mrunmayee P. Toraskar. (2015) Inhibition of carbonic anhydrase isoforms I, II, IX and XII with Schiff’s bases incorporating iminoureido moieties. Journal of Enzyme Inhibition and Medicinal Chemistry 30:6, pages 901-907.
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Zahid H. Chohan, Ali U. Shaikh, Abdul Rauf & Claudiu T. Supuran. (2006) Antibacterial, antifungal and cytotoxic properties of novel N-substituted sulfonamides from 4-hydroxycoumarin. Journal of Enzyme Inhibition and Medicinal Chemistry 21:6, pages 741-748.
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Zahid H. Chohan, Abdul Rauf, Muhammad M. Naseer, Muhammad A. Somra & Claudiu T. Supuran. (2006) Antibacterial, antifungal and cytotoxic properties of some sulfonamide-derived chromones. Journal of Enzyme Inhibition and Medicinal Chemistry 21:2, pages 173-177.
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Silvia Pastorekova, Seppo Parkkila, Jaromir Pastorek & Claudiu T. Supuran. (2004) Review Article. Journal of Enzyme Inhibition and Medicinal Chemistry 19:3, pages 199-229.
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Claudiu T Supuran & Andrea Scozzafava. (2002) Applications of carbonic anhydrase inhibitors and activators in therapy. Expert Opinion on Therapeutic Patents 12:2, pages 217-242.
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Articles from other publishers (18)

Mustafa Durgun, Hasan Turkmen, Mariangela Ceruso & Claudiu T. Supuran. (2016) Synthesis of 4-sulfamoylphenyl-benzylamine derivatives with inhibitory activity against human carbonic anhydrase isoforms I, II, IX and XII. Bioorganic & Medicinal Chemistry 24:5, pages 982-988.
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Mariangela Ceruso, Fabrizio Carta, Sameh M. Osman, Zeid Alothman, Simona Maria Monti & Claudiu T. Supuran. (2015) Inhibition studies of bacterial, fungal and protozoan β-class carbonic anhydrases with Schiff bases incorporating sulfonamide moieties. Bioorganic & Medicinal Chemistry 23:15, pages 4181-4187.
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Mustafa Durgun, Hasan Turkmen, Mariangela Ceruso & Claudiu T. Supuran. (2015) Synthesis of Schiff base derivatives of 4-(2-aminoethyl)-benzenesulfonamide with inhibitory activity against carbonic anhydrase isoforms I, II, IX and XII. Bioorganic & Medicinal Chemistry Letters 25:11, pages 2377-2381.
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Busra Sarikaya, Mariangela Ceruso, Fabrizio Carta & Claudiu T. Supuran. (2014) Inhibition of carbonic anhydrase isoforms I, II, IX and XII with novel Schiff bases: Identification of selective inhibitors for the tumor-associated isoforms over the cytosolic ones. Bioorganic & Medicinal Chemistry 22:21, pages 5883-5890.
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Gihane Nasr, Alina Cristian, Mihail Barboiu, Daniella Vullo, Jean-Yves Winum & Claudiu T. Supuran. (2014) Carbonic anhydrase inhibitors. Inhibition of human cytosolic isoforms I and II with (reduced) Schiff’s bases incorporating sulfonamide, carboxylate and carboxymethyl moieties. Bioorganic & Medicinal Chemistry 22:10, pages 2867-2874.
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Shazia Naheed, Farzana Mehmood, Hafiz Badaruddin Ahmad, Waheed Ahmad & Ghulam Zakria. (2013) Synthesis of novel Schiff base doped sol–gel silicas. Journal of Sol-Gel Science and Technology 68:2, pages 294-301.
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Sofian S. Mohamed, Abdalkarem R. Tamer, Salah M. Bensaber, Mousa I. Jaeda, Nouri B. Ermeli, Aemen Ali Allafi, Ibrahim A. Mrema, Mabrouk Erhuma, Anton Hermann & Abdul M. Gbaj. (2013) Design, synthesis, molecular modeling, and biological evaluation of sulfanilamide-imines derivatives as potential anticancer agents. Naunyn-Schmiedeberg's Archives of Pharmacology 386:9, pages 813-822.
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Claudiu T. Supuran & Jean‐Yves Winum. 2009. Drug Design of Zinc‐Enzyme Inhibitors. Drug Design of Zinc‐Enzyme Inhibitors 399 413 .
Jerapan Krungkrai, Sudaratana R. Krungkrai & Claudiu T. Supuran. 2009. Drug Design of Zinc‐Enzyme Inhibitors. Drug Design of Zinc‐Enzyme Inhibitors 335 357 .
Jerapan Krungkrai, Sudaratana R. Krungkrai & Claudiu T. Supuran. (2008) Carbonic anhydrase inhibitors: Inhibition of Plasmodium falciparum carbonic anhydrase with aromatic/heterocyclic sulfonamides—in vitro and in vivo studies. Bioorganic & Medicinal Chemistry Letters 18:20, pages 5466-5471.
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Claudiu T. Supuran & Andrea Scozzafava. (2007) Carbonic anhydrases as targets for medicinal chemistry. Bioorganic & Medicinal Chemistry 15:13, pages 4336-4350.
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Claudiu T Supuran. (2007) Therapeutic applications of the carbonic anhydrase inhibitors. Therapy 4:3, pages 355-378.
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Alexander Hillebrecht, Claudiu T. Supuran & Gerhard Klebe. (2006) Integrated Approach Using Protein and Ligand Information to Analyze Selectivity- and Affinity-Determining Features of Carbonic Anhydrase Isozymes. ChemMedChem 1:8, pages 839-853.
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Laure C. Bouchez, Māris Turks, Srinivas Reddy Dubbaka, Freddy Fonquerne, Cotinica Craita, Sylvain Laclef & Pierre Vogel. (2005) Sulfur dioxide mediated one-pot, four-component synthesis of polyfunctional sulfones and sulfonamides, including medium-ring cyclic derivatives. Tetrahedron 61:48, pages 11473-11487.
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Luca Puccetti, Giuseppe Fasolis, Daniela Vullo, Zahid H. Chohan, Andrea Scozzafava & Claudiu T. Supuran. (2005) Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff’s bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes. Bioorganic & Medicinal Chemistry Letters 15:12, pages 3096-3101.
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Jerapan Krungkrai, Andrea Scozzafava, Sutarnthip Reungprapavut, Sudaratana R. Krungkrai, Roonglawan Rattanajak, Sumalee Kamchonwongpaisan & Claudiu T. Supuran. (2005) Carbonic anhydrase inhibitors. Inhibition of Plasmodium falciparum carbonic anhydrase with aromatic sulfonamides: towards antimalarials with a novel mechanism of action?. Bioorganic & Medicinal Chemistry 13:2, pages 483-489.
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Maria del Pilar Corena, Molly M. Fiedler, Leslie VanEkeris, Chingkuang Tu, David N. Silverman & Paul J. Linser. (2004) Alkalization of larval mosquito midgut and the role of carbonic anhydrase in different species of mosquitoes. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 137:3, pages 207-225.
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Claudiu T. Supuran, Andrea Scozzafava & Angela Casini. (2002) Carbonic anhydrase inhibitors. Medicinal Research Reviews 23:2, pages 146-189.
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