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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 26, 2011 - Issue 6
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Research Article

Topological, hydrophobicity, and other descriptors on α-glucosidase inhibition: a QSAR study on xanthone derivatives

N.S. Hari Narayana MoorthyREQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 687 Rua do Campo Alegre, Porto, PortugalCorrespondence[email protected] [email protected]
,
Maria J. RamosREQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 687 Rua do Campo Alegre, Porto, Portugal
&
Pedro A. FernandesREQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 687 Rua do Campo Alegre, Porto, Portugal
Pages 755-766 | Received 22 May 2010, Accepted 15 Dec 2010, Published online: 01 Feb 2011

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Doudou Huang, Zenan Du, Yanhong Chen, Zhiying Dong, Xiujuan Wang, Mengshuang Li, Feng Zhang, Wansheng Chen & Lianna Sun. (2021) Bio-Guided Isolation of Two New Hypoglycemic Triterpenoid Saponins from Polygonum capitatum. Drug Design, Development and Therapy 15, pages 5001-5010.
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Domenico Gadaleta & Emilio Benfenati. (2021) A descriptor-based analysis to highlight the mechanistic rationale of mutagenicity. Journal of Environmental Science and Health, Part C 39:3, pages 269-292.
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Isnatin Miladiyah, Jumina Jumina, Sofia Mubarika Haryana & Mustofa Mustofa. (2018) Biological activity, quantitative structure–activity relationship analysis, and molecular docking of xanthone derivatives as anticancer drugs. Drug Design, Development and Therapy 12, pages 149-158.
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Articles from other publishers (9)

Giovanna J. Lavado, Diego Baderna, Domenico Gadaleta, Marta Ultre, Kunal Roy & Emilio Benfenati. (2021) Ecotoxicological QSAR modeling of the acute toxicity of organic compounds to the freshwater crustacean Thamnocephalus platyurus. Chemosphere 280, pages 130652.
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Rosa Perestrelo, Catarina Silva, Miguel X. Fernandes & José S. Câmara. (2019) Prediction of Terpenoid Toxicity Based on a Quantitative Structure–Activity Relationship Model. Foods 8:12, pages 628.
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Clementina M.M. Santos, Marisa Freitas & Eduarda Fernandes. (2018) A comprehensive review on xanthone derivatives as α-glucosidase inhibitors. European Journal of Medicinal Chemistry 157, pages 1460-1479.
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N. S. Hari Narayana Moorthy, Silvia A. Martins, Sergio F. Sousa, Maria J. Ramos & Pedro A. Fernandes. (2014) Classification study of solvation free energies of organic molecules using machine learning techniques. RSC Adv. 4:106, pages 61624-61630.
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Neelesh Maheshwari, Anju Goyal & Sourabh Jain. (2013) 2D-QSAR study of 1,4-benzodiazepine-2-ones as potent anti-trypanosomal agents. Medicinal Chemistry Research 22:12, pages 6002-6009.
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Yan Liu, Lin Ma, Wen-Hua Chen, Hwangseo Park, Zhuofeng Ke & Bo Wang. (2013) Binding Mechanism and Synergetic Effects of Xanthone Derivatives as Noncompetitive α-Glucosidase Inhibitors: A Theoretical and Experimental Study. The Journal of Physical Chemistry B 117:43, pages 13464-13471.
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N.S.H.N. Moorthy, Natércia F. Brás, Maria J. Ramos & Pedro A. Fernandes. (2012) Virtual screening and QSAR study of some pyrrolidine derivatives as α-mannosidase inhibitors for binding feature analysis. Bioorganic & Medicinal Chemistry 20:24, pages 6945-6959.
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N. S. Hari Narayana Moorthy, Maria J. Ramos & Pedro A. Fernandes. (2011) Comparative Structural Analysis of α‐Glucosidase Inhibitors on Difference Species: A Computational Study. Archiv der Pharmazie 345:4, pages 265-274.
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N.S. Hari Narayana Moorthy, Maria J. Ramos & Pedro A. Fernandes. (2011) Structural analysis of α-glucosidase inhibitors by validated QSAR models using topological and hydrophobicity based descriptors. Chemometrics and Intelligent Laboratory Systems 109:2, pages 101-112.
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