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Christopher H. George, Alice N. Mitchell, Ryan Preece, Mark L. Bannister & Zaheer Yousef. (2016) Pleiotropic mechanisms of action of perhexiline in heart failure. Expert Opinion on Therapeutic Patents 26:9, pages 1049-1059.
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Abdur Rauf, Anees Ahmed Khalil, Samir Awadallah, Shahid Ali Khan, Tareq Abu‐Izneid, Muhammad Kamran, Hassan A. Hemeg, Mohammad S. Mubarak, Ahood Khalid & Polrat Wilairatana. (2023) Reactive oxygen species in biological systems: Pathways, associated diseases, and potential inhibitors—A review. Food Science & Nutrition.
Crossref
Crossref
Simin Meng, Yi Yu, Shuo Yu, Shiyu Zhu, Mengjia Shi, Meixiang Xiang & Hong Ma. (2023) Advances in Metabolic Remodeling and Intervention Strategies in Heart Failure. Journal of Cardiovascular Translational Research.
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Alessandra Cipriano, Monica Viviano, Alessandra Feoli, Ciro Milite, Giuliana Sarno, Sabrina Castellano & Gianluca Sbardella. (2023) NADPH Oxidases: From Molecular Mechanisms to Current Inhibitors. Journal of Medicinal Chemistry 66:17, pages 11632-11655.
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Crossref
Vasco Sequeira, Mark T. Waddingham, Hirotsugu Tsuchimochi, Christoph Maack & James T. Pearson. (2023) Mechano-energetic uncoupling in hypertrophic cardiomyopathy: Pathophysiological mechanisms and therapeutic opportunities. Journal of Molecular and Cellular Cardiology Plus, pages 100036.
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Cristina Nocella, Alessandra D’Amico, Vittoria Cammisotto, Simona Bartimoccia, Valentina Castellani, Lorenzo Loffredo, Leonardo Marini, Giulia Ferrara, Matteo Testa, Giulio Motta, Beatrice Benazzi, Fabio Zara, Giacomo Frati, Sebastiano Sciarretta, Pasquale Pignatelli, Francesco Violi, Roberto Carnevale & Smile Group. (2023) Structure, Activation, and Regulation of NOX2: At the Crossroad between the Innate Immunity and Oxidative Stress-Mediated Pathologies. Antioxidants 12:2, pages 429.
Crossref
Crossref
Christopher M. Dustin, Eugenia Cifuentes-Pagano & Patrick J. Pagano. 2023. NADPH Oxidases Revisited: From Function to Structure. NADPH Oxidases Revisited: From Function to Structure
343
377
.
Ahmad S. Arabiyat, Daniel J. Yeisley, Viviana R. Güiza-ArgüelloFatir QureshiRobert A. CulibrkJuergen HahnMariah S. Hahn. (2022) Effects of Stromal Cell Conditioned Medium and Antipurinergic Treatment on Macrophage Phenotype. Tissue Engineering Part C: Methods 28:12, pages 656-671.
Crossref
Crossref
Morgan Salmon. (2022) NADPH Oxidases in Aortic Aneurysms. Antioxidants 11:9, pages 1830.
Crossref
Crossref
Daire Cantillon, Aaron Goff, Stuart Taylor, Emad Salehi, Katy Fidler, Simon Stoneham & Simon J Waddell. (2022) Searching for new therapeutic options for the uncommon pathogen Mycobacterium chimaera: an open drug discovery approach. The Lancet Microbe 3:5, pages e382-e391.
Crossref
Crossref
Nicole O. Barioni, Fatemeh Derakhshan, Luana Tenorio Lopes, Hiroshi OnimaruArijit Roy, Fiona McDonald, Erika ScheibliMufaddal I. BaghdadwalaNegar Heidari, Manisha Bharadia, Keiko IkedaItaru YazawaYasumasa Okada, Michael B. Harris, Mathias DutschmannRichard J. A. Wilson. (2022) Novel oxygen sensing mechanism in the spinal cord involved in cardiorespiratory responses to hypoxia. Science Advances 8:12.
Crossref
Crossref
Dylan J. Kendrick, Ramesh C. Mishra, Cini Mathew John, Hai-Lei Zhu & Andrew P. Braun. (2022) Effects of Pharmacological Inhibitors of NADPH Oxidase on Myogenic Contractility and Evoked Vasoactive Responses in Rat Resistance Arteries. Frontiers in Physiology 12.
Crossref
Crossref
Markos Tadele, Solomon M. Abay, Peter Asaga, Eyasu Makonnen & Asrat Hailu. (2021) In vitro growth inhibitory activity of Medicines for Malaria Venture pathogen box compounds against Leishmania aethiopica. BMC Pharmacology and Toxicology 22:1.
Crossref
Crossref
Heather Parker, Harry Jones, Christopher Kaldor, Mark Hampton & Christine Winterbourn. (2021) Neutrophil NET Formation with Microbial Stimuli Requires Late Stage NADPH Oxidase Activity. Antioxidants 10:11, pages 1791.
Crossref
Crossref
Basel H. Abuaita, Gautam J. Sule, Tracey L. Schultz, Fushan Gao, Jason S. Knight & Mary X. O’Riordan. (2021) The IRE1α Stress Signaling Axis Is a Key Regulator of Neutrophil Antimicrobial Effector Function. The Journal of Immunology 207:1, pages 210-220.
Crossref
Crossref
Elisa Sassetti, Mads H. Clausen & Luca Laraia. (2021) Small-Molecule Inhibitors of Reactive Oxygen Species Production. Journal of Medicinal Chemistry 64:9, pages 5252-5275.
Crossref
Crossref
Leticia Guadalupe Fragoso-Morales, José Correa-Basurto & Martha Cecilia Rosales-Hernández. (2021) Implication of Nicotinamide Adenine Dinucleotide Phosphate (NADPH) Oxidase and Its Inhibitors in Alzheimer’s Disease Murine Models. Antioxidants 10:2, pages 218.
Crossref
Crossref
Mathieu ChocryLudovic Leloup. (2020) The NADPH Oxidase Family and Its Inhibitors. Antioxidants & Redox Signaling 33:5, pages 332-353.
Crossref
Crossref
Zeyad D. Nassar, Chui Yan Mah, Margaret M. Centenera, Swati Irani, Martin C. Sadowski, Julia S. Scott, Elizabeth V. Nguyen, Shilpa R. Nagarajan, Max Moldovan, David J. Lynn, Roger J. Daly, Andrew J. Hoy & Lisa M. Butler. (2020) Fatty Acid Oxidation Is an Adaptive Survival Pathway Induced in Prostate Tumors by HSP90 Inhibition. Molecular Cancer Research 18:10, pages 1500-1511.
Crossref
Crossref
Samir Gautam, Yannick Stahl, Grant M. Young, Rebecca Howell, Avi J. Cohen, Derek A. Tsang, Tommy Martin, Lokesh Sharma & Charles S. Dela Cruz. (2020) Quantification of bronchoalveolar neutrophil extracellular traps and phagocytosis in murine pneumonia. American Journal of Physiology-Lung Cellular and Molecular Physiology 319:4, pages L661-L669.
Crossref
Crossref
Sofia UrnerFlorence HoJay C. JhaDan ZieglerKarin Jandeleit-Dahm. (2020) NADPH Oxidase Inhibition: Preclinical and Clinical Studies in Diabetic Complications. Antioxidants & Redox Signaling 33:6, pages 415-434.
Crossref
Crossref
Katrin Schröder. (2020) NADPH oxidases: Current aspects and tools. Redox Biology 34, pages 101512.
Crossref
Crossref
Joana Reis, Marta Massari, Sara Marchese, Marta Ceccon, Friso S. Aalbers, Federica Corana, Sergio Valente, Antonello Mai, Francesca Magnani & Andrea Mattevi. (2020) A closer look into NADPH oxidase inhibitors: Validation and insight into their mechanism of action. Redox Biology 32, pages 101466.
Crossref
Crossref
Snigdha Tiash, Jake Saunders, Christopher J.S. Hart, John H. Ryan, Andrew G. Riches & Tina S. Skinner-Adams. (2020) An image-based Pathogen Box screen identifies new compounds with anti-Giardia activity and highlights the importance of assay choice in phenotypic drug discovery. International Journal for Parasitology: Drugs and Drug Resistance 12, pages 60-67.
Crossref
Crossref
Dan Li, Zhukai Cong, Cui Yang & Xi Zhu. (2020) Inhibition of LPS-induced Nox2 activation by VAS2870 protects alveolar epithelial cells through eliminating ROS and restoring tight junctions. Biochemical and Biophysical Research Communications 524:3, pages 575-581.
Crossref
Crossref
Vu Thao-Vi Dao, Mahmoud H. Elbatreek, Sebastian Altenhöfer, Ana I. Casas, Mayra P. Pachado, Christopher T. Neullens, Ulla G. Knaus & Harald H.H.W. Schmidt. (2020) Isoform-selective NADPH oxidase inhibitor panel for pharmacological target validation. Free Radical Biology and Medicine 148, pages 60-69.
Crossref
Crossref
Claudia Sacchetto, Vasco Sequeira, Edoardo Bertero, Jan Dudek, Christoph Maack & Martina Calore. (2019) Metabolic Alterations in Inherited Cardiomyopathies. Journal of Clinical Medicine 8:12, pages 2195.
Crossref
Crossref
Evan DeVallanceYao LiMichael J. JurczakEugenia Cifuentes-PaganoPatrick J. Pagano. (2019) The Role of NADPH Oxidases in the Etiology of Obesity and Metabolic Syndrome: Contribution of Individual Isoforms and Cell Biology. Antioxidants & Redox Signaling 31:10, pages 687-709.
Crossref
Crossref
Fiona Augsburger, Aleksandra Filippova, Delphine Rasti, Tamara Seredenina, Magdalena Lam, Ghassan Maghzal, Zahia Mahiout, Pidder Jansen-Dürr, Ulla G. Knaus, James Doroshow, Roland Stocker, Karl-Heinz Krause & Vincent Jaquet. (2019) Pharmacological characterization of the seven human NOX isoforms and their inhibitors. Redox Biology 26, pages 101272.
Crossref
Crossref
Paul J.M. WijnkerVasco SequeiraDiederik W.D. KusterJolanda van der Velden. (2019) Hypertrophic Cardiomyopathy: A Vicious Cycle Triggered by Sarcomere Mutations and Secondary Disease Hits. Antioxidants & Redox Signaling 31:4, pages 318-358.
Crossref
Crossref
Mavis A A Tenkorang, Phong Duong & Rebecca L Cunningham. (2019) NADPH Oxidase Mediates Membrane Androgen Receptor–Induced Neurodegeneration. Endocrinology 160:4, pages 947-963.
Crossref
Crossref
Pavel Avdonin, Elena Rybakova, Piotr Avdonin, Sergei Trufanov, Galina Mironova, Alexandra Tsitrina & Nikolay Goncharov. (2019) VAS2870 Inhibits Histamine-Induced Calcium Signaling and vWF Secretion in Human Umbilical Vein Endothelial Cells. Cells 8:2, pages 196.
Crossref
Crossref
Clinton G. L. Veale. (2019) Unpacking the Pathogen Box—An Open Source Tool for Fighting Neglected Tropical Disease. ChemMedChem 14:4, pages 386-453.
Crossref
Crossref
Valérian Pasche, Benoît Laleu & Jennifer Keiser. (2018)
Early Antischistosomal Leads Identified from
in Vitro
and
in Vivo
Screening of the Medicines for Malaria Venture Pathogen Box
. ACS Infectious Diseases 5:1, pages 102-110.
Crossref
Crossref
Lucía Gonzalez-Perilli, Carolina Prolo & María Noel Álvarez. 2019. Bioactive Lipids in Health and Disease. Bioactive Lipids in Health and Disease
85
95
.
Merry W. Ma, Jing Wang, Krishnan M. Dhandapani, Ruimin Wang & Darrell W. Brann. (2018) NADPH oxidases in traumatic brain injury – Promising therapeutic targets?. Redox Biology 16, pages 285-293.
Crossref
Crossref
Albert van der Vliet, Karamatullah Danyal & David E Heppner. (2018) Dual oxidase: a novel therapeutic target in allergic disease. British Journal of Pharmacology 175:9, pages 1401-1418.
Crossref
Crossref
Hannah Noordali, Brodie L. Loudon, Michael P. Frenneaux & Melanie Madhani. (2018) Cardiac metabolism — A promising therapeutic target for heart failure. Pharmacology & Therapeutics 182, pages 95-114.
Crossref
Crossref
Aude Angelini, Xinchun Pi & Liang Xie. (2017) Dioxygen and Metabolism; Dangerous Liaisons in Cardiac Function and Disease. Frontiers in Physiology 8.
Crossref
Crossref
Merry W. Ma, Jing Wang, Quanguang Zhang, Ruimin Wang, Krishnan M. Dhandapani, Ratna K. Vadlamudi & Darrell W. Brann. (2017) NADPH oxidase in brain injury and neurodegenerative disorders. Molecular Neurodegeneration 12:1.
Crossref
Crossref
Declan McLaughlin, Youyou Zhao, Karla M O'Neill, Kevin S Edgar, Philip D Dunne, Anna M Kearney, David J Grieve & Barbara J McDermott. (2017) Signalling mechanisms underlying doxorubicin and Nox2 NADPH oxidase‐induced cardiomyopathy: involvement of mitofusin‐2. British Journal of Pharmacology 174:21, pages 3677-3695.
Crossref
Crossref
Silvia Sorce, Roland Stocker, Tamara Seredenina, Rikard Holmdahl, Adriano Aguzzi, Adriano Chio, Antoine Depaulis, Freddy Heitz, Peter Olofsson, Tomas Olsson, Venceslas Duveau, Despina Sanoudou, Sara Skosgater, Antonia Vlahou, Dominique Wasquel, Karl-Heinz Krause & Vincent Jaquet. (2017) NADPH oxidases as drug targets and biomarkers in neurodegenerative diseases: What is the evidence?. Free Radical Biology and Medicine 112, pages 387-396.
Crossref
Crossref
G J McBean, M G López & F K Wallner. (2016) Redox‐based therapeutics in neurodegenerative disease. British Journal of Pharmacology 174:12, pages 1750-1770.
Crossref
Crossref
G Teixeira, C Szyndralewiez, S Molango, S Carnesecchi, F Heitz, P Wiesel & J M Wood. (2016) Therapeutic potential of NADPH oxidase 1/4 inhibitors. British Journal of Pharmacology 174:12, pages 1647-1669.
Crossref
Crossref
J Haslund‐Vinding, G McBean, V Jaquet & F Vilhardt. (2016) NADPH oxidases in oxidant production by microglia: activating receptors, pharmacology and association with disease. British Journal of Pharmacology 174:12, pages 1733-1749.
Crossref
Crossref
Yu-jie Li, Wei Zhao, Xu-jiao Yu, Feng-xian Li, Zi-ting Liu, Le Li & Shi-yuan Xu. (2017) Activation of p47phox as a Mechanism of Bupivacaine-Induced Burst Production of Reactive Oxygen Species and Neural Toxicity. Oxidative Medicine and Cellular Longevity 2017, pages 1-14.
Crossref
Crossref
Merry W. Ma, Jing Wang, Krishnan M. Dhandapani & Darrell W. Brann. (2017) NADPH Oxidase 2 Regulates NLRP3 Inflammasome Activation in the Brain after Traumatic Brain Injury. Oxidative Medicine and Cellular Longevity 2017, pages 1-18.
Crossref
Crossref
V. Thao-Vi DaoAna I. CasasGhassan J. MaghzalTamara SeredeninaNina KaludercicNatalia Robledinos-AntonFabio Di LisaRoland StockerPietro GhezziVincent JaquetAntonio CuadradoHarald H.H.W. Schmidt. (2015) Pharmacology and Clinical Drug Candidates in Redox Medicine. Antioxidants & Redox Signaling 23:14, pages 1113-1129.
Crossref
Crossref
Kazufumi HiranoWoei Shin ChenAdeline L.W. ChuengAngela A. DunneTamara SeredeninaAleksandra FilippovaSumitra RamachandranAngela BridgesLaiq ChaudryGary PettmanCraig AllanSarah DuncanKiew Ching LeeJean LimMay Thu MaAgnes B. OngNicole Y. YeShabina NasirSri MulyanidewiChiu Cheong AwPamela P. OonShihua LiaoDizheng LiDouglas G. JohnsNeil D. MillerCeri H. DaviesEdward R. BrowneYasuji MatsuokaDeborah W. ChenVincent JaquetA. Richard Rutter. (2015) Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 Inhibitor. Antioxidants & Redox Signaling 23:5, pages 358-374.
Crossref
Crossref
Becky A. DieboldSusan M.E. SmithYang LiJ. David Lambeth. (2015) NOX2 As a Target for Drug Development: Indications, Possible Complications, and Progress. Antioxidants & Redox Signaling 23:5, pages 375-405.
Crossref
Crossref
Sebastian AltenhöferKim A. RadermacherPamela W.M. KleikersKirstin WinglerHarald H.H.W. Schmidt. (2015) Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement. Antioxidants & Redox Signaling 23:5, pages 406-427.
Crossref
Crossref
Roger M. Beadle, Lynne K. Williams, Michael Kuehl, Sarah Bowater, Khalid Abozguia, Francisco Leyva, Zaheer Yousef, Anton J.M. Wagenmakers, Frank Thies, John Horowitz & Michael P. Frenneaux. (2015) Improvement in Cardiac Energetics by Perhexiline in Heart Failure Due to Dilated Cardiomyopathy. JACC: Heart Failure 3:3, pages 202-211.
Crossref
Crossref
Patrick Page. (2014) Advances and strategies in NADPH oxidase inhibitors and activators patents. Pharmaceutical Patent Analyst 3:4, pages 387-409.
Crossref
Crossref
Eugenia Cifuentes-PaganoDaniel N. MeijlesPatrick J. Pagano. (2014) The Quest for Selective Nox Inhibitors and Therapeutics: Challenges, Triumphs and Pitfalls. Antioxidants & Redox Signaling 20:17, pages 2741-2754.
Crossref
Crossref
Anna KoniorAgata SchrammMarta Czesnikiewicz-GuzikTomasz J. Guzik. (2014) NADPH Oxidases in Vascular Pathology. Antioxidants & Redox Signaling 20:17, pages 2794-2814.
Crossref
Crossref
Thomas V.A. Murray, Aminah Ahmad & Alison C. Brewer. (2014) Reactive oxygen at the heart of metabolism. Trends in Cardiovascular Medicine 24:3, pages 113-120.
Crossref
Crossref
Thanh H. Nguyen, Cher-Rin Chong, Wai P. Chan & John D. Horowitz. (2014) New Developments in Anti-Anginal Therapy: Roles of Ivabradine, Allopurinol and of Agents Modifying Myocardial Metabolism. World Journal of Cardiovascular Diseases 04:07, pages 368-376.
Crossref
Crossref
Kim A. RadermacherKirstin WinglerFriederike LanghauserSebastian AltenhöferPamela KleikersJ.J. Rob HermansMartin Hrabě de AngelisChristoph KleinschnitzHarald H.H.W. Schmidt. (2013) Neuroprotection After Stroke by Targeting NOX4 As a Source of Oxidative Stress. Antioxidants & Redox Signaling 18:12, pages 1418-1427.
Crossref
Crossref
Timo KahlesRalf P. Brandes. (2013) Which NADPH Oxidase Isoform Is Relevant for Ischemic Stroke? The Case for Nox 2. Antioxidants & Redox Signaling 18:12, pages 1400-1417.
Crossref
Crossref
Silvia Sorce, Karl-Heinz Krause & Vincent Jaquet. (2012) Targeting NOX enzymes in the central nervous system: therapeutic opportunities. Cellular and Molecular Life Sciences 69:14, pages 2387-2407.
Crossref
Crossref