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Research Article

Synthesis, antiproliferative and antimicrobial activity of new Mannich bases bearing 1,2,4-triazole moiety

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Pages 786-795 | Received 11 Jul 2013, Accepted 30 Sep 2013, Published online: 10 Feb 2014

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Łukasz Popiołek, Anna Biernasiuk, Kinga Paruch, Paweł Patrejko & Monika Wujec. (2017) Synthesis and evaluation of antimicrobial properties of new Mannich bases of 4,5-disubstituted-1,2,4-triazole-3-thiones. Phosphorus, Sulfur, and Silicon and the Related Elements 192:7, pages 880-885.
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Jasneet Rana & R.P. Chaudhary. (2023) Excited state dynamics of 1,2,4-triazolyl-thio-pentane-2,4-dione system and their conversion to biologically active novel triazole-S-pyrazole hybrids. Journal of Molecular Structure 1291, pages 136015.
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Najmeh Zeinali & Ali Darehkordi. (2023) A facile and catalyst-free microwave-promoted method for the synthesis of 3-trifluoromethyl 1,2,4-triazole-5-thiones. Tetrahedron Letters 129, pages 154727.
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Qing-Hu Teng, Feng-Lai Lu, Kai Wang, Li-Ya Zhou & Dian-Peng Li. (2023) Chemodivergent Photocatalyzed Heterocyclization of Hydrazones and Isothiocyanates for the Selectivity Synthesis of 2-Amino-1,3,4-thiadiazoles and 1,2,4-Triazole-3-thiones. The Journal of Organic Chemistry 88:11, pages 7104-7116.
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Reda El‐Sayed Mansour, Hanan Gaber Abdulwahab & Hend M. El‐Sehrawi. (2023) Novel benzimidazole‐linked (thio)barbiturates as non‐hydroxamate HDAC6 inhibitors targeting leukemia: Design, synthesis, and structure–activity relationship. Archiv der Pharmazie 356:6.
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Senthil Kumar Raju, Priyadharshini Vengadhajalaphathy, Revathy Sundaram, Sangeetha Periyasamy, Thatchayani Chinnaraj & Praveen Sekar. (2023) Recent advances in biological applications of mannich bases — An overview. International Journal of Pharmaceutical Chemistry and Analysis 10:1, pages 15-27.
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Gheorghe Roman. (2022) Anticancer Activity of Mannich Bases: A Review of Recent Literature. ChemMedChem 17:16.
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Neha V. Bhilare, Vinayak S. Marulkar, Pramodkumar J. Shirote, Shailaja A. Dombe, Vilas J. Pise, Pallavi L. Salve, Shantakumar M. Biradar, Vishal D. Yadav, Prakash D. Jadhav, Anjali A. Bodhe, Smita P. Borkar, Prachi M. Ghadge, Pournima A. Shelar, Apurva V. Jadhav & Kirti C. Godse. (2022) Mannich Bases: Centrality in Cytotoxic Drug Design. Medicinal Chemistry 18:7, pages 735-756.
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Islam H. El Azab & Nadia A.A. Elkanzi. (2020) Design, Synthesis, and Antimicrobial Evaluation of New Annelated Pyrimido[2,1-c][1,2,4]triazolo[3,4-f][1,2,4]triazines. Molecules 25:6, pages 1339.
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Wagdy M. Eldehna, Hadia Almahli, Tamer M. Ibrahim, Mohamed Fares, Tarfah Al-Warhi, Frank M. Boeckler, Adnan A. Bekhit & Hatem A. Abdel-Aziz. (2019) Synthesis, in vitro biological evaluation and in silico studies of certain arylnicotinic acids conjugated with aryl (thio)semicarbazides as a novel class of anti-leishmanial agents. European Journal of Medicinal Chemistry 179, pages 335-346.
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Esha Dhall, Sonika Jain, Achal Mishra, Jaya Dwivedi & Swapnil Sharma. (2018) Synthesis and Evaluation of Some Phenyl Substituted Azetidine Containing 1, 2, 4‐triazole Derivatives as Antibacterial Agents. Journal of Heterocyclic Chemistry 55:12, pages 2859-2869.
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Łukasz Popiołek, Anna Biernasiuk, Kinga Paruch, Anna Malm & Monika Wujec. (2018) Synthesis and in vitro antimicrobial activity screening of new pipemidic acid derivatives. Archives of Pharmacal Research 41:6, pages 633-645.
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Xue-Feng Wang, Shuai Zhang, Bao-Lin Li, Ji-Jun Zhao, Yu-Ming Liu, Rui-Lian Zhang, Bo Li & Bao-Quan Chen. (2017) Synthesis and biological evaluation of disulfides bearing 1,2,4-triazole moiety as antiproliferative agents. Medicinal Chemistry Research 26:12, pages 3367-3374.
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Surender Kumar & Dinesh Kumar Sharma. (2017) Ultrasound promoted green synthesis of benzofuran substituted thiazolo[3,2-b][1,2,4]triazoles. Green Processing and Synthesis 6:1, pages 73-77.
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Bao-Lin Li, Bo Li, Rui-Lian Zhang, Ji-Jun Zhao, Xue-Feng Wang, Yu-Ming Liu, Yan-Ping Shi, Jin-Biao Liu & Bao-Quan Chen. (2016) Synthesis and antiproliferative evaluation of novel 1,2,4-triazole derivatives incorporating benzisoselenazolone scaffold. Bioorganic & Medicinal Chemistry Letters 26:4, pages 1279-1281.
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Ionuţ Ledeţi, Vasile Bercean, Anda Alexa, Codruţa Şoica, Lenuţa-Maria Şuta, Cristina Dehelean, Cristina Trandafirescu, Delia Muntean, Monica Licker & Adriana Fuliaş. (2015) Preparation and Antibacterial Properties of Substituted 1,2,4-Triazoles. Journal of Chemistry 2015, pages 1-5.
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