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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 31, 2016 - Issue 2
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Research Article

Crocus cancellatus subsp. damascenus stigmas: chemical profile, and inhibition of α-amylase, α-glucosidase and lipase, key enzymes related to type 2 diabetes and obesity

Monica R. LoizzoDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende (CS), Italy,
,
Mariangela MarrelliDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende (CS), Italy,
,
Alessandro PuglieseDepartment of Food Sciences, University of Parma, Parco Area delle Scienze 47/A, Parma, Italy, and
,
Filomena ConfortiDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende (CS), Italy,
,
Farsad NadjafiSchool of Agriculture, Ferdowsi University of Mashhad, Mashhad, Iran
,
Francesco MenichiniDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende (CS), Italy,
&
Rosa TundisDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende (CS), Italy, Correspondence[email protected]
 show all
Pages 212-218 | Received 30 Sep 2014, Accepted 29 Jan 2015, Published online: 20 Mar 2015

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Sonia Floris, Antonella Fais, Rosaria Medda, Francesca Pintus, Alessandra Piras, Amit Kumar, Piotr Marek Kuś, Gunilla Torstensdotter Westermark & Benedetta Era. (2021) Washingtonia filifera seed extracts inhibit the islet amyloid polypeptide fibrils formations and α-amylase and α-glucosidase activity. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 517-524.
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Xue Li, Jin Xie, Hong Fan, Jin Tan, Dingkun Zhang, Yang Bao, Funeng Geng, Jin Pei & Hongyan Ma. (2023) Stigma and petals of Crocus sativus L.: Review and comparison of phytochemistry and pharmacology. Arabian Journal of Chemistry 16:8, pages 104918.
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Mehedi Hasan, Md. Monirul Islam, Md. Obayed Raihan, Afrina Brishti, Avizit Das, Jakaria Shawon, Fariha Sultana, Md. Wasim Bari, Mohammad Amirul Islam, Siew Hua Gan & A. M. Swaraz. (2023) Clonal Blumea lacera (Burm. f.) DC. ameliorates diabetic conditions by modulating carbohydrate and lipid hydrolases: a combine in vivo experimental and chemico-biological interaction study. 3 Biotech 13:5.
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Renata Matraszek-Gawron, Mirosława Chwil, Karol Terlecki & Michał Marian Skoczylas. (2022) Current Knowledge of the Antidepressant Activity of Chemical Compounds from Crocus sativus L.. Pharmaceuticals 16:1, pages 58.
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Micaela Giani, Luigia Gervasi, Monica Rosa Loizzo & Rosa María Martínez-Espinosa. (2022) Carbon Source Influences Antioxidant, Antiglycemic, and Antilipidemic Activities of Haloferax mediterranei Carotenoid Extracts. Marine Drugs 20:11, pages 659.
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Raheleh Shakeri, Bahram Savari, Mahsa N. Sheikholeslami, Tayebeh Radjabian, Jalal Khorshidi & Maliheh Safavi. (2022) Untargeted Metabolomics Analysis of Crocus cancellatus subsp. damascenus (Herb.) B. Mathew Stigmas and Their Anticarcinogenic Effect on Breast Cancer Cells. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-15.
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Kun Zhang, Xue-Lin Chen, Xia Zhao, Ji-Yan Ni, Han-Lei Wang, Mei Han & Yu-Mei Zhang. (2022) Antidiabetic potential of Catechu via assays for α-glucosidase, α-amylase, and glucose uptake in adipocytes. Journal of Ethnopharmacology 291, pages 115118.
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Han Lü, Yuanyuan Zuo, Xiuhua Meng, Xiaoqin Ding, Tunyu Jian, Yan Liu, Bingru Ren, Jian Chen & Weilin Li. (2021) Phenolic profiles, antioxidant activity and inhibition of digestive enzymes of water caltrop pericarps. Journal of the Science of Food and Agriculture 102:6, pages 2342-2351.
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Wenming Chen, Cui Zhou, Jiansheng Chen, Meizhu Wang, Fang Zhou, Chunmei Wang, Xu Zhang & Wen Zhou. (2022) Design and synthesis of epigallocatechin (EGC) analogs selective to inhibit α-amylase over α-glucosidases via the incorporation of caffeine acid and its derivatives. Bioorganic Chemistry 119, pages 105515.
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Olha Mykhailenko, Ivan Bezruk, Victoriia Volochai, Volodymyr Mishchenko, Liudas Ivanauskas & Victoriya Georgiyants. (2022) Phytochemical Analysis and Antioxidant Activity of Crocus speciosus Leaves. Phyton 91:1, pages 207-221.
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Jue Cui, Siman Zeng & Chuyun Zhang. (2021) Anti‐hyperglycaemic effects of Burdock ( Arctium lappa L .) leaf flavonoids through inhibiting α‐amylase and α‐glucosidase . International Journal of Food Science & Technology 57:1, pages 541-551.
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Olha Mykhailenko, Vilma Petrikaitė, Michal Korinek, Mohamed El-Shazly, Bing-Hung Chen, Chia-Hung Yen, Chung-Fan Hsieh, Ivan Bezruk, Asta Dabrišiūtė, Liudas Ivanauskas, Victoriya Georgiyants & Tsong-Long Hwang. (2021) Bio-guided bioactive profiling and HPLC-DAD fingerprinting of Ukrainian saffron (Crocus sativus stigmas): moving from correlation toward causation. BMC Complementary Medicine and Therapies 21:1.
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Leila Mohtashami, Mohammad Sadegh Amiri, Mahin Ramezani, Seyed Ahmad Emami & Jesus Simal-Gandara. (2021) The genus Crocus L.: A review of ethnobotanical uses, phytochemistry and pharmacology. Industrial Crops and Products 171, pages 113923.
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Ying Li, Bo Chen, Hai-Yan Cao, Jing-En Li, Ling-Li Chen & Qing-Feng Zhang. (2021) Pancreatic lipase inhibitory activity of Bambusa multiplex cv. Fernleaf leaf extract in vitro and in vivo . Food & Function 12:16, pages 7440-7447.
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Sarah Megrous, Sam Al-Dalali, Xiao Zhao, Chao Chen, Yongqiang Cao, Imane Bourouis, Aicha Mekkaoui, Zhijie Yang & Zhennai Yang. (2020) Evaluation of Antidiabetic Activities of Casein Hydrolysates by a Bacillus Metalloendopeptidase. International Journal of Peptide Research and Therapeutics 26:4, pages 2519-2527.
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Francimauro S. Morais, Kirley M. Canuto, Paulo R.V. Ribeiro, Alison B. Silva, Otilia D.L. Pessoa, Cleverson D.T. Freitas, Nylane M.N. Alencar, Ariclecio C. Oliveira & Márcio V. Ramos. (2020) Chemical profiling of secondary metabolites from Himatanthus drasticus (Mart.) Plumel latex with inhibitory action against the enzymes α-amylase and α-glucosidase: In vitro and in silico assays. Journal of Ethnopharmacology 253, pages 112644.
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Xiao-Lin Qiu & Qing-Feng Zhang. (2019) Chemical profile and pancreatic lipase inhibitory activity of Sinobambusa tootsik (Sieb.) Makino leaves . PeerJ 7, pages e7765.
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Hanna Zielinska-Blizniewska, Przemyslaw Sitarek, Anna Merecz-Sadowska, Katarzyna Malinowska, Karolina Zajdel, Marta Jablonska, Tomasz Sliwinski & Radoslaw Zajdel. (2019) Plant Extracts and Reactive Oxygen Species as Two Counteracting Agents with Anti- and Pro-Obesity Properties. International Journal of Molecular Sciences 20:18, pages 4556.
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Olga Mykhailenko, Volodymyr Kovalyov, Olga Goryacha, Liudas Ivanauskas & Victoriya Georgiyants. (2019) Biologically active compounds and pharmacological activities of species of the genus Crocus: A review. Phytochemistry 162, pages 56-89.
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Gokhan Zengin, Muhammad Zakariyyah Aumeeruddy, Alina Diuzheva, József Jekő, Zoltán Cziáky, Aysegul Yıldıztugay, Evren Yıldıztugay & Mohamad Fawzi Mahomoodally. (2019) A comprehensive appraisal on Crocus chrysanthus (Herb.) Herb. flower extracts with HPLC–MS/MS profiles, antioxidant and enzyme inhibitory properties. Journal of Pharmaceutical and Biomedical Analysis 164, pages 581-589.
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Ji Wang, Kaiying Du, Li Fang, Chunlei Liu, Weihong Min & Jingsheng Liu. (2018) Evaluation of the antidiabetic activity of hydrolyzed peptides derived from Juglans mandshurica Maxim. fruits in insulin-resistant HepG2 cells and type 2 diabetic mice . Journal of Food Biochemistry 42:3, pages e12518.
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Alireza Milajerdi, Shima Jazayeri, Vida Bitarafan, Najmeh Hashemzadeh, Elham Shirzadi, Zhaleh Derakhshan, Mahmood Mahmoodi, Alireza Rayati, Abolghassem Djazayeri & Shahin Akhondzadeh. (2017) The effect of saffron ( Crocus sativus L.) hydro-alcoholic extract on liver and renal functions in type 2 diabetic patients: A double-blinded randomized and placebo control trial. Journal of Nutrition & Intermediary Metabolism 9, pages 6-11.
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Karima Sayah, Ilias Marmouzi, Hanae Naceiri Mrabti, Yahia Cherrah & My El Abbes Faouzi. (2017) Antioxidant Activity and Inhibitory Potential of Cistus salviifolius (L.) and Cistus monspeliensis (L.) Aerial Parts Extracts against Key Enzymes Linked to Hyperglycemia . BioMed Research International 2017, pages 1-7.
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