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Journal of Enzyme Inhibition Volume 1, 1987 - Issue 4
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Research Article

Irreversible Inhibition of Gaba-T by Halogenated Analogues of βAlanine

Daniel Schirlin Merrell Dow Research Institute, Strasbourg Center, 16 rue d'Ankara, 67084, Strasbourg, Cedex, France
,
Sylvie Baltzer Merrell Dow Research Institute, Strasbourg Center, 16 rue d'Ankara, 67084, Strasbourg, Cedex, France
,
Jean-Georges Heydt Merrell Dow Research Institute, Strasbourg Center, 16 rue d'Ankara, 67084, Strasbourg, Cedex, France
&
Michel J. Jung Merrell Dow Research Institute, Strasbourg Center, 16 rue d'Ankara, 67084, Strasbourg, Cedex, France
Pages 243-258 | Received 02 Jun 1986, Published online: 27 Sep 2008

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Richard B. Silverman. (1988) The Potential Use of Mechanism-Based Enzyme Inactivators in Medicine. Journal of Enzyme Inhibition 2:2, pages 73-90.
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Articles from other publishers (4)

Marina García-Ramos & Iván Lavandera. (2022) Transaminases as suitable catalysts for the synthesis of enantiopure β,β-difluoroamines. Organic & Biomolecular Chemistry 20:5, pages 984-988.
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Richard B. Silverman. (2018) Design and Mechanism of GABA Aminotransferase Inactivators. Treatments for Epilepsies and Addictions. Chemical Reviews 118:7, pages 4037-4070.
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Richard B. Silverman & Cheryl L. Chamberlain Roscher. (1996) Mechanism-based inactivation of γ-aminobutyric acid aminotransferase by 3-amino-4-fluorobutanoic acid. Bioorganic & Medicinal Chemistry 4:9, pages 1521-1535.
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Takashi Tsukamoto & Tomoya Kitazume. (1992) Lewis Acid-Promoted Reaction of β,β-Difluorinated N , O -Acetal with Silylated Nucleophiles . Chemistry Letters 21:7, pages 1377-1380.
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