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Research Article

The Potential Use of Mechanism-Based Enzyme Inactivators in Medicine

Pages 73-90 | Published online: 27 Sep 2008

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Zeynab Fakhar, Suhashni Naiker, Claudio N. Alves, Thavendran Govender, Glenn E.M. Maguire, Jeronimo Lameira, Gyanu Lamichhane, Hendrik G. Kruger & Bahareh Honarparvar. (2016) A comparative modeling and molecular docking study on Mycobacterium tuberculosis targets involved in peptidoglycan biosynthesis. Journal of Biomolecular Structure and Dynamics 34:11, pages 2399-2417.
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Y. Nishiya, K. Hagihara, A. Kurihara, N. Okudaira, N.A. Farid, O. Okazaki & T. Ikeda. (2009) Comparison of mechanism-based inhibition of human cytochrome P450 2C19 by ticlopidine, clopidogrel, and prasugrel. Xenobiotica 39:11, pages 836-843.
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Hans-Ulrich Demuth. (1990) Recent Developments in Inhibiting Cysteine and Serine Proteases. Journal of Enzyme Inhibition 3:4, pages 249-278.
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Sida Shen, Peter F. Doubleday, Pathum M. Weerawarna, Wei Zhu, Neil L. Kelleher & Richard B. Silverman. (2020) Mechanism-Based Design of 3-Amino-4-Halocyclopentenecarboxylic Acids as Inactivators of GABA Aminotransferase. ACS Medicinal Chemistry Letters 11:10, pages 1949-1955.
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Michael V. Fiandalo, Daniel T. Gewirth & James L. Mohler. (2019) Potential impact of combined inhibition of 3α-oxidoreductases and 5α-reductases on prostate cancer. Asian Journal of Urology 6:1, pages 50-56.
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Hui Dong, Qingqing Han, Yu Guo, Jiansong Ju, Shanshan Wang, Chao Yuan, Wei Long, Xin He, Shujing Xu & Sheng Li. (2018) Enzymatic characterization and crystal structure of biosynthetic alanine racemase from Pseudomonas aeruginosa PAO1. Biochemical and Biophysical Research Communications 503:4, pages 2319-2325.
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Hui Dong, Tingting Hu, Guangzheng He, Deren Lu, Jianxun Qi, Yanshu Dou, Wei Long, Xin He, Jiansong Ju & Dan Su. (2018) Structural features and kinetic characterization of alanine racemase from Bacillus pseudofirmus OF4. Biochemical and Biophysical Research Communications 497:1, pages 139-145.
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Xiaoliang Sun, Guangzheng He, Xiaoyan Wang, Shujing Xu, Jiansong Ju & Xiaoling Xu. (2015) Crystal Structure of a Thermostable Alanine Racemase from Thermoanaerobacter tengcongensis MB4 Reveals the Role of Gln360 in Substrate Selection. PLOS ONE 10:7, pages e0133516.
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Honggang Zhou, Zhenzhen Li, Guofang Zhang, Shujing Xu, Zhaona Tang, Xianming Zhu, Hui Dong & Jiansong Ju. (2014) Crystallization and preliminary X-ray study of biosynthetic alanine racemase from Pseudomonas aeruginosa PAO1 . Acta Crystallographica Section F Structural Biology Communications 70:12, pages 1616-1619.
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Oluwatoyin A. Asojo, Sarah K. Nelson, Sara Mootien, Yashang Lee, Wanderson C. Rezende, Daniel A. Hyman, Monica M. Matsumoto, Scott Reiling, Alan Kelleher, Michel Ledizet, Raymond A. Koski & Karen G. Anthony. (2014) Structural and biochemical analyses of alanine racemase from the multidrug-resistant Clostridium difficile strain 630 . Acta Crystallographica Section D Biological Crystallography 70:7, pages 1922-1933.
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Yashang Lee, Sara Mootien, Carolyn Shoen, Michelle Destefano, Pier Cirillo, Oluwatoyin A. Asojo, Kacheong R. Yeung, Michel Ledizet, Michael H. Cynamon, Paul A. Aristoff, Raymond A. Koski, Paul A. Kaplan & Karen G. Anthony. (2013) Inhibition of mycobacterial alanine racemase activity and growth by thiadiazolidinones. Biochemical Pharmacology 86:2, pages 222-230.
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Zhangwei Xue, Yi Hu, Shujing Xu, Kouhei Ohnishi, Yanhe Ma, Jiansong Ju & Baohua Zhao. (2013) Characterization and preliminary mutation analysis of a thermostable alanine racemase from Thermoanaerobacter tengcongensis MB4. Extremophiles 17:4, pages 611-621.
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Hui Dong, Shujing Xu, Xiaoyun Lu, Guangzheng He, Ranran Zhao, Shuai Chen, Sheng Fu & Jiansong Ju. (2013) Crystallization and preliminary X-ray study of a thermostable alanine racemase from Thermoanaerobacter tengcongensis MB4 . Acta Crystallographica Section F Structural Biology and Crystallization Communications 69:6, pages 660-662.
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Yumi Nishiya, Katsunobu Hagihara, Takashi Ito, Masami Tajima, Shin-ichi Miura, Atsushi Kurihara, Nagy A. Farid & Toshihiko Ikeda. (2009) Mechanism-Based Inhibition of Human Cytochrome P450 2B6 by Ticlopidine, Clopidogrel, and the Thiolactone Metabolite of Prasugrel. Drug Metabolism and Disposition 37:3, pages 589-593.
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