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Journal of Enzyme Inhibition Volume 4, 1991 - Issue 3
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Research Article

The Isoenzyme Selectivity of AH 21–132 as an Inhibitor of Cyclic Nucleotide Phosphodiesterase Activity

Keith R.F. Elliott Department of Biochemistry and Molecular Biology, the Smooth Muscle Research Group, The University of Manchester, Manchester, M13 9PT, UK
,
Jacqueline L. Berry Department of Physiological Sciences, The Medical School, The University of Manchester, Manchester, M13 9PT, UK
,
Alison J. Bate Department of Biochemistry and Molecular Biology, the Smooth Muscle Research Group, The University of Manchester, Manchester, M13 9PT, UK
,
Robert W. Foster Department of Biochemistry and Molecular Biology, the Smooth Muscle Research Group, The University of Manchester, Manchester, M13 9PT, UK
&
Roger C. Small Department of Biochemistry and Molecular Biology, the Smooth Muscle Research Group, The University of Manchester, Manchester, M13 9PT, UK
Pages 245-251 | Received 02 Apr 1990, Published online: 27 Sep 2008

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J-A Karlsson & D Aldous. (1997) Phosphodiesterase 4 inhibitors for the treatment of asthma. Expert Opinion on Therapeutic Patents 7:9, pages 989-1003.
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Takao Saeki & Yasutaka Takase. (1996) Section Review Cardiovascular & Renal: Phosphodiesterase 5 inhibitors in development for cardiovascular therapy. Expert Opinion on Investigational Drugs 5:11, pages 1477-1486.
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Articles from other publishers (15)

Stéphanie Parra, Florence Laurent, Guy Subra, Carine Deleuze-Masquefa, Veronique Benezech, Jean-Roch Fabreguettes, Jean-Pierre Vidal, Tristan Pocock, Keith Elliott, Roger Small, Roger Escale, Alain Michel, Jean-Pierre Chapat & Pierre-Antoine Bonnet. (2001) Imidazo[1,2-a]quinoxalines: synthesis and cyclic nucleotide phosphodiesterase inhibitory activity. European Journal of Medicinal Chemistry 36:3, pages 255-264.
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Olivier Vitse, Florence Laurent, Tristan M. Pocock, Véronique Bénézech, Lahcen Zanik, Keith R.F. Elliott, Guy Subra, Karine Portet, Jacques Bompart, Jean-Pierre Chapat, Roger C. Small, Alain Michel & Pierre-Antoine Bonnet. (1999) New imidazo[1,2-a]pyrazine derivatives with bronchodilatory and cyclic nucleotide phosphodiesterase inhibitory activities. Bioorganic & Medicinal Chemistry 7:6, pages 1059-1065.
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Tristan M Pocock, Florence Laurent, Lynne M Isaac, Peter Chiu, Keith R.F Elliott, Robert W Foster, Alain Michel, Pierre-Antoine Bonnet & Roger C Small. (1997) Effects of SCA40 on bovine trachealis muscle and on cyclic nucleotide phosphodiesterases. European Journal of Pharmacology 334:1, pages 75-85.
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. (2015) POSTER COMMUNICATIONS. British Journal of Pharmacology 117:S1.
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Siegfried B. Christensen, Walter E. DeWolfJrJr, M. Dominic Ryan & Theodore J. Torphy. 1996. Phosphodiesterase Inhibitors. Phosphodiesterase Inhibitors 185 207 .
Hiroichi Nagai, Hiroshi Takeda, Takehisa Iwama, Shuji Yamaguchi & Hiroshi Mori. (1995) Studies on Anti-allergic Action of AH 21-132, a Novel Isozyme-Selective Phosphodiesterase Inhibitor in Airways. Japanese Journal of Pharmacology 67:2, pages 149-156.
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S.J. Cook, K. Archer, A. Martin, K.H. Buchheit, J.R. Fozard, T. Müller, A.J. Miller, K.R.F. Elliott, R.W. Foster & R.C. Small. (2012) Further analysis of the mechanisms underlying the tracheal relaxant action of SCA40. British Journal of Pharmacology 114:1, pages 143-151.
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Siegfried B. Christensen & Theodore J. Torphy. 1994. 185 194 .
G. Edwards & A. H. Weston. 1994. Pharmacology of Smooth Muscle. Pharmacology of Smooth Muscle 469 531 .
RW Foster, K. Rakshi, J.R. Carpenter & RC Small. (2012) Trials of the bronchodilator activity of the isoenzyme‐selective phosphodiesterase inhibitor AH 21‐132 in healthy volunteers during a methacholine challenge test.. British Journal of Clinical Pharmacology 34:6, pages 527-534.
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M. A. GIEMBYCZ & G. DENT. (2006) Prospects for selective cyclic nucleotide phosphodiesterase inhibitors in the treatment of bronchial asthma. Clinical & Experimental Allergy 22:3, pages 337-344.
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. (1991) POSTER COMMUNICATIONS. British Journal of Pharmacology 104:S1, pages 97P-270P.
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Mohammed Shahid, Ronald G.M. Amsterdam, Jacob Boer, Ronald E. Berge, C David Nicholson & Johan Zaagsma. (1991) The presence of five cyclic nucleotide phosphodiesterase isoenzyme activities in bovine tracheal smooth muscle and the functional effects of selective inhibitors. British Journal of Pharmacology 104:2, pages 471-477.
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Christian Schudt, Susanne Winder, Betina Müller & Dieter Ukena. (1991) Zardaverine as a selective inhibitor of phosphodiesterase isozymes. Biochemical Pharmacology 42:1, pages 153-162.
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Roger C. Small, Jacqueline L. Berry, John P. Boyle, Ian D. Chapman, Keith R.F. Elliott, Robert W. Foster & Andrew J. Watt. (1991) Biochemical and electrical aspects of the tracheal relaxant action of AH 21-132. European Journal of Pharmacology 192:3, pages 417-426.
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