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Journal of Enzyme Inhibition Volume 10, 1995 - Issue 1
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Research Article

Different Extent of Inhibition of Pyruvate Dehydrogenase and 2-Oxoglutarate Dehydrogenase Both Containing Endogenous Thiamine Pyrophosphate, by Some Anticoenzyme Analogues

Slawomir Strumilo Department of Biochemistry, Institute of Biology, University of Warsaw, Branch in Bialystok, Swierkowa, 20B, 15-950, Bialystok, Poland
,
Maria Czygier Department of Biochemistry, Institute of Biology, University of Warsaw, Branch in Bialystok, Swierkowa, 20B, 15-950, Bialystok, Poland
&
Jolanta Markiewicz Department of Biochemistry, Institute of Biology, University of Warsaw, Branch in Bialystok, Swierkowa, 20B, 15-950, Bialystok, Poland
Pages 65-72 | Received 13 Mar 1995, Accepted 26 Jun 1995, Published online: 27 Sep 2008

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Ewa Grabowska, Magdalena Czerniecka, Urszula Czyżewska, Aneta Zambrzycka, Zenon Łotowski & Adam Tylicki. (2021) Differences in the efficiency of 3-deazathiamine and oxythiamine pyrophosphates as inhibitors of pyruvate dehydrogenase complex and growth of HeLa cells in vitro. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 122-129.
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Articles from other publishers (10)

Hyung Jun Kim, Yingying Li, Michael Zimmermann, Yunmi Lee, Hui Wen Lim, Alvin Swee Leong Tan, Inhee Choi, Yoonae Ko, Sangchul Lee, Jeong Jea Seo, Mooyoung Seo, Hee Kyoung Jeon, Jonathan Cechetto, Joey Kuok Hoong Yam, Liang Yang, Uwe Sauer, Soojin Jang & Kevin Pethe. (2022) Pharmacological perturbation of thiamine metabolism sensitizes Pseudomonas aeruginosa to multiple antibacterial agents. Cell Chemical Biology 29:8, pages 1317-1324.e5.
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Adam Tylicki, Zenon Łotowski, Magdalena Siemieniuk & Artur Ratkiewicz. (2018) Thiamine and selected thiamine antivitamins — biological activity and methods of synthesis. Bioscience Reports 38:1.
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Fang Zhang, Jinit Masania, Attia Anwar, Mingzhan Xue, Daniel Zehnder, Hemali Kanji, Naila Rabbani & Paul J. Thornalley. (2016) The uremic toxin oxythiamine causes functional thiamine deficiency in end-stage renal disease by inhibiting transketolase activity. Kidney International 90:2, pages 396-403.
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Victoria I. Bunik, Adam Tylicki & Nikolay V. Lukashev. (2013) Thiamin diphosphate-dependent enzymes: from enzymology to metabolic regulation, drug design and disease models. FEBS Journal 280:24, pages 6412-6442.
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Victoria I. Bunik & Alisdair R. Fernie. (2009) Metabolic control exerted by the 2-oxoglutarate dehydrogenase reaction: a cross-kingdom comparison of the crossroad between energy production and nitrogen assimilation. Biochemical Journal 422:3, pages 405-421.
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Ratna Singh & Andrea Mozzarelli. 2009. Chemogenomics. Chemogenomics 93 122 .
Adam Tylicki, Anna Łempicka, Katarzyna Romaniuk‐Demonchaux, Jan Czerniecki, Paweł Dobrzyń & Sławomir Strumiło. (2003) Effect of oxythiamin on growth rate, survival ability and pyruvate decarboxylase activity in Saccharomyces cerevisiae . Journal of Basic Microbiology 43:6, pages 522-529.
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S Strumiło, M Czygier, J Kondracikowska, P Dobrzyń & J Czerniecki. (2002) Kinetic and spectral investigation of allosteric interaction of coenzymes with 2-oxo acid dehydrogenase complexes. Journal of Molecular Structure 614:1-3, pages 221-226.
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Slawomir Strumilo, Jan Czerniecki & Pawel Dobrzyn. (1999) Regulatory Effect of Thiamin Pyrophosphate on Pig Heart Pyruvate Dehydrogenase Complex. Biochemical and Biophysical Research Communications 256:2, pages 341-345.
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D. A. Oparin, T. I. Zimatkina, I. P. Chernikevich & S. V. Zabrodskaya. (1998) Synthesis and biological activity of the oxythiamin derivatives modified with respect to thiazole. Pharmaceutical Chemistry Journal 32:8, pages 415-418.
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