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Research Article

Inhibiting Effects of Spermidine Derivatives on Trypanosoma Cruzz Trypanothione Reductase

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Pages 97-114 | Received 22 Apr 1996, Published online: 27 Sep 2008

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Roberto Docampo & Aníbal Eugénio Vercesi. (2022) Mitochondrial Ca 2+ and Reactive Oxygen Species in Trypanosomatids . Antioxidants & Redox Signaling 36:13-15, pages 969-983.
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Elodie Jagu, Sébastien Pomel, Stéphanie Pethe, Philippe M. Loiseau & Raphaël Labruère. (2017) Polyamine-based analogs and conjugates as antikinetoplastid agents. European Journal of Medicinal Chemistry 139, pages 982-1015.
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R. Docampo & S.N.J. Moreno. 2017. American Trypanosomiasis Chagas Disease. American Trypanosomiasis Chagas Disease 371 400 .
Mary C. O?Sullivan, Timothy B. Durham, Hannah E. Valdes, Kelly L. Dauer, Nicholas J. Karney, Andrew C. Forrestel, Cyrus J. Bacchi & Jerome F. Baker. (2015) Dibenzosuberyl substituted polyamines and analogs of clomipramine as effective inhibitors of trypanothione reductase; molecular docking, and assessment of trypanocidal activities. Bioorganic & Medicinal Chemistry 23:5, pages 996-1010.
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Roberto Docampo & Silvia N.J. Moreno. 2010. American Trypanosomiasis. American Trypanosomiasis 365 392 .
M. Omar F. Khan. (2017) Trypanothione Reductase: A Viable Chemotherapeutic Target for Antitrypanosomal and Antileishmanial Drug Design. Drug Target Insights 2, pages 117739280700200.
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Dolores Molero, Julieta Coro, Rolando Pérez, Margarita Suárez, Roberto Martínez-Álvarez, Antonio Herrera & Nazario Martín. (2007) 1H and13C NMR spectral assignment of alkyl and polyamine-linked bis(2-thioxo-[1,3,5]-thiadiazinan-3-yl) carboxylic acids. Magnetic Resonance in Chemistry 45:1, pages 93-98.
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Michael L. Berger, Abdallah Y. Bitar, Matthew J. Waitner, Patrick Rebernik & Mary C. O’Sullivan. (2006) Polyamines and the NMDA receptor: Modifying intrinsic activities with aromatic substituents. Bioorganic & Medicinal Chemistry Letters 16:11, pages 2837-2841.
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Mark J. Dixon, Richard I. Maurer, Cristina Biggi, Julen Oyarzabal, Jonathan W. Essex & Mark Bradley. (2005) Mechanism and structure?activity relationships of norspermidine-based peptidic inhibitors of trypanothione reductase. Bioorganic & Medicinal Chemistry 13:14, pages 4513-4526.
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Siddharth Pandey, Kristin A Fletcher, Sheila N Baker, Gary A Baker, Joseph DeLuca, Michael F Fennie & Mary C O’Sullivan. (2004) Solution aggregation of anti-trypanosomal N-(2-naphthylmethyl)ated polyamines. Journal of Photochemistry and Photobiology A: Chemistry 162:2-3, pages 387-398.
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Donald J. AbrahamDavid S. Fries & Alan H. Fairlamb. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 1033 1087 .
Zhili Li, Michael W Fennie, Bruce Ganem, Matthew T Hancock, Muris Koba?lija, Donna Rattendi, Cyrus J Bacchi & Mary C O'Sullivan. (2001) Polyamines with N -(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents. Bioorganic & Medicinal Chemistry Letters 11:2, pages 251-254.
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L. Flohé, H.J. Hecht & P. Steinert. (1999) Glutathione and trypanothione in parasitic hydroperoxide metabolism. Free Radical Biology and Medicine 27:9-10, pages 966-984.
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Mary C. O'Sullivan, Qibing Zhou, Zhili Li, Timothy B. Durham, Donna Rattendi, Schennella Lane & Cyrus J. Bacchi. (1997) Polyamine derivatives as inhibitors of trypanothione reductase and assessment of their trypanocidal activities. Bioorganic & Medicinal Chemistry 5:12, pages 2145-2155.
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