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Journal of Enzyme Inhibition Volume 14, 1999 - Issue 3
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Original Article

New Thrombin Inhibitors Based on D-CHA-PRO-Derivatives

Torsten Steinmetzer Inst. of Biochemistry & Biophysics, Friedrich Schiller University, Philosophenweg 12, 0-07743, Jena, GermanyCorrespondence[email protected]
,
Mjanganzezeg Batdorsdhjin Inst. of Biochemistry & Biophysics, Friedrich Schiller University, Philosophenweg 12, 0-07743, Jena, Germany
,
Peter Kleinwächter Inst. of Biochemistry & Biophysics, Friedrich Schiller University, Philosophenweg 12, 0-07743, Jena, Germany
,
Lydia Seyfarth Inst. of Biochemistry & Biophysics, Friedrich Schiller University, Philosophenweg 12, 0-07743, Jena, Germany
,
Georg Greiner Inst. of Biochemistry & Biophysics, Friedrich Schiller University, Philosophenweg 12, 0-07743, Jena, Germany
,
Siegmund Reißmann Inst. of Biochemistry & Biophysics, Friedrich Schiller University, Philosophenweg 12, 0-07743, Jena, Germany
&
JÖRg Stürzebecher Centre for Vascular Biology and Medicine, Friedrich Schiller University, Nordhäuser Str. 78, D-99012, Erfurt, Germany
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Pages 203-216 | Received 01 May 1998, Published online: 02 Jul 2009

Citations (10)

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Riyaj S. Tamboli, Rajani Giridhar, Hardik P. Gandhi, Ashish M. Kanhed, Hemant M. Mande & Mange Ram Yadav. (2016) Design, green synthesis and pharmacological evaluation of novel 5,6-diaryl-1,2,4-triazines bearing 3-morpholinoethylamine moiety as potential antithrombotic agents. Journal of Enzyme Inhibition and Medicinal Chemistry 31:5, pages 704-713.
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Torsten Steinmetzer, Jörg Hauptmann & Jörg Stürzebecher. (2001) Advances in the development of thrombin inhibitors. Expert Opinion on Investigational Drugs 10:5, pages 845-864.
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Torsten Steinmetzer, Andrea Schweinttz, Sebastian Künzel, Peter Wikstrsöm, JÖRg Hauptmann & JÖRg Stürzebecher. (2001) Structure-Activity Relationships of New NAPAP-Analogs. Journal of Enzyme Inhibition 16:3, pages 241-249.
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Claudiu T. Supuran, Fabrizio Briganti, Andrea Scozzafava & Marc A. Ilies. (2000) Protease Inhibitors: Part 4. Synthesis of Weakly Basic Thrombin Inhibitors Incorporating Pyridinium-Sulfanilylaminoguanidine Moieties. Journal of Enzyme Inhibition 15:4, pages 335-356.
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Articles from other publishers (6)

Donald J. AbrahamMimi L. Quan, Peter W. Glunz & Joseph M. Luettgen. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 1 45 .
Gero L. Becker, Frank Sielaff, Manuel E. Than, Iris Lindberg, Sophie Routhier, Robert Day, Yinghui Lu, Wolfgang Garten & Torsten Steinmetzer. (2009) Potent Inhibitors of Furin and Furin-like Proprotein Convertases Containing Decarboxylated P1 Arginine Mimetics. Journal of Medicinal Chemistry 53:3, pages 1067-1075.
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Rainer Friedrich, Daniel Riester, Peter Göttig, Marcel Thürk, Andreas Schwienhorst & Wolfram Bode. (2008) Structure of a novel thrombin inhibitor with an uncharged d-amino acid as P1 residue. European Journal of Medicinal Chemistry 43:6, pages 1330-1335.
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Lucija Peterlin-Mašic̆, Gregor Mlinšek, Tomaž Šolmajer, Alenka Trampuš-Bakija, Mojca Stegnar & Danijel Kikelj. (2003) Novel thrombin inhibitors incorporating non-basic partially saturated heterobicyclic P1-Arginine mimetics. Bioorganic & Medicinal Chemistry Letters 13:5, pages 789-794.
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Sebastian Künzel, Andrea Schweinitz, Siegmund Reißmann, Jörg Stürzebecher & Torsten Steinmetzer. (2002) 4-Amidinobenzylamine-Based inhibitors of urokinase. Bioorganic & Medicinal Chemistry Letters 12:4, pages 645-648.
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Jörg Hauptmann & Jörg Stürzebecher. (1999) Synthetic Inhibitors of Thrombin and Factor Xa. Thrombosis Research 93:5, pages 203-241.
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