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Original Article

The frequency and clinical significance of intra-amniotic inflammation in women with preterm uterine contractility but without cervical change: do the diagnostic criteria for preterm labor need to be changed?

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Pages 1212-1221 | Received 25 Aug 2011, Accepted 19 Sep 2011, Published online: 25 Apr 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Nardhy Gomez-Lopez, Roberto Romero, Marcia Arenas-Hernandez, Bogdan Panaitescu, Valeria Garcia-Flores, Tara N. Mial, Aashna Sahi & Sonia S. Hassan. (2018) Intra-amniotic administration of lipopolysaccharide induces spontaneous preterm labor and birth in the absence of a body temperature change. The Journal of Maternal-Fetal & Neonatal Medicine 31:4, pages 439-446.
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Sun Min Kim, Roberto Romero, JoonHo Lee, Piya Chaemsaithong, Nikolina Docheva & Bo Hyun Yoon. (2016) Gastric fluid versus amniotic fluid analysis for the identification of intra-amniotic infection due to Ureaplasma species. The Journal of Maternal-Fetal & Neonatal Medicine 29:16, pages 2579-2587.
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Piya Chaemsaithong, Roberto Romero, Steven J. Korzeniewski, Zhong Dong, Lami Yeo, Sonia S. Hassan, Yeon Mee Kim, Bo Hyun Yoon & Tinnakorn Chaiworapongsa. (2015) A point of care test for the determination of amniotic fluid interleukin-6 and the chemokine CXCL-10/IP-10. The Journal of Maternal-Fetal & Neonatal Medicine 28:13, pages 1510-1519.
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Sun Min Kim, Roberto Romero, Jeong Woo Park, Kyung Joon Oh, Jong Kwan Jun & Bo Hyun Yoon. (2015) The relationship between the intensity of intra-amniotic inflammation and the presence and severity of acute histologic chorioamnionitis in preterm gestation. The Journal of Maternal-Fetal & Neonatal Medicine 28:13, pages 1500-1509.
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Roberto Romero, Jezid Miranda, Tinnakorn Chaiworapongsa, Piya Chaemsaithong, Francesca Gotsch, Zhong Dong, Ahmed I. Ahmed, Bo Hyun Yoon, Sonia S. Hassan, Chong J. Kim, Steven J. Korzeniewski, Lami Yeo & Yeon Mee Kim. (2015) Sterile intra-amniotic inflammation in asymptomatic patients with a sonographic short cervix: prevalence and clinical significance. The Journal of Maternal-Fetal & Neonatal Medicine 28:11, pages 1343-1359.
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Roberto Romero, Nicholas Kadar, Jezid Miranda, Steven J. Korzeniewski, Alyse G. Schwartz, Piya Chaemsaithong, Wade Rogers, Eleazar Soto, Francesca Gotsch, Lami Yeo, Sonia S. Hassan & Tinnakorn Chaiworapongsa. (2014) The diagnostic performance of the Mass Restricted (MR) score in the identification of microbial invasion of the amniotic cavity or intra-amniotic inflammation is not superior to amniotic fluid interleukin-6. The Journal of Maternal-Fetal & Neonatal Medicine 27:8, pages 757-769.
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Nikolaos E. Evangelinakis, Elektra N. Polyzou, George E. Salamalekis, Antigoni J. Kotsaki, Charalampos G. Chrelias, Evangelos J. Giamarellos-Bourboulis & Demetrios P. Kassanos. (2013) Alterations in the cellular component of the maternal immune system in a murine preterm delivery model. The Journal of Maternal-Fetal & Neonatal Medicine 26:10, pages 1024-1029.
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Christina Fotopoulou, Sarah Kyeyamwa, Mattea Linder, Daniela Thieme, Sebastian Hartenstein, Oliver Klein, Joachim W. Dudenhausen, Wolfgang Henrich, Karim D. Kalache & Christian Bamberg. (2012) Proteomic analysis of midtrimester amniotic fluid to identify novel biomarkers for preterm delivery. The Journal of Maternal-Fetal & Neonatal Medicine 25:12, pages 2488-2493.
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Maria-Teresa Gervasi, Roberto Romero, Gabriella Bracalente, Tinnakorn Chaiworapongsa, Offer Erez, Zhong Dong, Sonia S. Hassan, Lami Yeo, Bo Hyun Yoon, Gil Mor, Luisa Barzon, Elisa Franchin, Valentina Militello & Giorgio Palù. (2012) Viral invasion of the amniotic cavity (VIAC) in the midtrimester of pregnancy. The Journal of Maternal-Fetal & Neonatal Medicine 25:10, pages 2002-2013.
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Kanako Gondo, Fumio Yamasaki, Makoto Nomiyama, Nami Hisamoto, Natsumi Yamashita, Takuya Nakagawa, Masazumi Ikeda, Satoko Tsuda, Masato Ishimatsu, Yuko Oshima, Takeshi Ono, Yutaka Kozuma, Yukiko Nakura, Itaru Yanagihara & Keisuke Tsumura. (2023) Relationship of maternal inflammatory response and fetal inflammatory response to duration and intensity of intra-amniotic infection and inflammation. Placenta 137, pages 23-30.
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Priya Prasad, Roberto Romero, Tinnakorn Chaiworapongsa, Nardhy Gomez-Lopez, Anderson Lo, Jose Galaz, Andreea B. Taran, Eunjung Jung, Francesca Gotsch, Nandor Gabor Than & Adi L. Tarca. (2023) Further Evidence that an Episode of Premature Labor Is a Pathologic State: Involvement of the Insulin-Like Growth Factor System. Fetal Diagnosis and Therapy, pages 1-12.
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Bo Hyun Yoon, Roberto Romero, Kyung Joon Oh, Hyeon Ji Kim, Eunjung Jung, Francesca Gotsch & Manaphat Suksai. (2023) Reply: Intraamniotic infection/inflammation in threatened midtrimester miscarriage, cervical insufficiency, and preterm labor without cervical changes. American Journal of Obstetrics and Gynecology 228:4, pages 480-483.
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Kyung Joon Oh, Roberto Romero, Hyeon Ji Kim, Eunjung Jung, Francesca Gotsch, Manaphat Suksai & Bo Hyun Yoon. (2022) The role of intraamniotic inflammation in threatened midtrimester miscarriage. American Journal of Obstetrics and Gynecology 227:6, pages 895.e1-895.e13.
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Nathalia M. Noda-Nicolau, Ourlad Alzeus G. Tantengco, Jossimara Polettini, Mariana C. Silva, Giovana F. C. Bento, Geovanna C. Cursino, Camila Marconi, Ronald F. Lamont, Brandie D. Taylor, Márcia G. Silva, Daniel Jupiter & Ramkumar Menon. (2022) Genital Mycoplasmas and Biomarkers of Inflammation and Their Association With Spontaneous Preterm Birth and Preterm Prelabor Rupture of Membranes: A Systematic Review and Meta-Analysis. Frontiers in Microbiology 13.
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Hyo Kyozuka, Tuyoshi Murata, Toma Fukuda, Erina Suzuki, Riho Yazawa, Shun Yasuda, Aya Kanno, Akiko Yamaguchi, Yuko Hashimoto & Keiya Fujimori. (2021) Labor dystocia and risk of histological chorioamnionitis and funisitis: a study from a single tertiary referral center. BMC Pregnancy and Childbirth 21:1.
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Nkechi Martina Odogwu, Jun Chen, Chinedum Amara Onebunne, Patricio Jeraldo, Lu Yang, Stephen Johnson, Funmilola A. Ayeni, Marina R. S. Walther-Antonio, Oladapo O. Olayemi, Nicholas Chia & Akinyinka O. Omigbodun. (2021) Predominance of Atopobium vaginae at Midtrimester: a Potential Indicator of Preterm Birth Risk in a Nigerian Cohort. mSphere 6:1.
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Feng Zhou, Chao Li & Song-Ying Zhang. (2021) NLRP3 inflammasome: a new therapeutic target for high-risk reproductive disorders?. Chinese Medical Journal 134:1, pages 20-27.
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Nardhy Gomez-Lopez & Roberto Romero. 2021. Reproductive Immunology. Reproductive Immunology 207 237 .
Kevin R. Theis, Roberto Romero, Kenichiro Motomura, Jose Galaz, Andrew D. Winters, Percy Pacora, Derek Miller, Rebecca Slutsky, Violetta Florova, Dustyn Levenson, Robert Para, Aneesha Varrey, Marian Kacerovsky, Chaur-Dong Hsu & Nardhy Gomez-Lopez. (2020) Microbial burden and inflammasome activation in amniotic fluid of patients with preterm prelabor rupture of membranes. Journal of Perinatal Medicine 48:2, pages 115-131.
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Bo Hyun Yoon, Roberto Romero, Jee Yoon Park, Kyung Joon Oh, JoonHo Lee, Agustin Conde-Agudelo & Joon-Seok Hong. (2019) Antibiotic administration can eradicate intra-amniotic infection or intra-amniotic inflammation in a subset of patients with preterm labor and intact membranes. American Journal of Obstetrics and Gynecology 221:2, pages 142.e1-142.e22.
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Kyung Joon Oh, Roberto Romero, Jee Yoon Park, Joon-Seok Hong & Bo Hyun Yoon. (2019) The earlier the gestational age, the greater the intensity of the intra-amniotic inflammatory response in women with preterm premature rupture of membranes and amniotic fluid infection by Ureaplasma species . Journal of Perinatal Medicine 47:5, pages 516-527.
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Yaozhu Leng, Roberto Romero, Yi Xu, Jose Galaz, Rebecca Slutsky, Marcia Arenas‐Hernandez, Valeria Garcia‐Flores, Kenichiro Motomura, Sonia S. Hassan, Andrea Reboldi & Nardhy Gomez‐Lopez. (2019) Are B cells altered in the decidua of women with preterm or term labor?. American Journal of Reproductive Immunology 81:5, pages e13102.
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Jerome F. StraussIIIIII, Roberto Romero, Nardhy Gomez-Lopez, Hannah Haymond-Thornburg, Bhavi P. Modi, Maria E. Teves, Laurel N. Pearson, Timothy P. York & Harvey A. Schenkein. (2018) Spontaneous preterm birth: advances toward the discovery of genetic predisposition. American Journal of Obstetrics and Gynecology 218:3, pages 294-314.e2.
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Nardhy Gomez-Lopez, Roberto Romero, Yi Xu, Olesya Plazyo, Ronald Unkel, Yaozhu Leng, Nandor Gabor Than, Tinnakorn Chaiworapongsa, Bogdan Panaitescu, Zhong Dong, Adi L. Tarca, Vikki M. Abrahams, Lami Yeo & Sonia S. Hassan. (2017) A Role for the Inflammasome in Spontaneous Preterm Labor With Acute Histologic Chorioamnionitis. Reproductive Sciences 24:10, pages 1382-1401.
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D. Oros, M. Strunk, P. Breton, C. Paules, R. Benito, E. Moreno, M. Garcés, J. Godino & J. Schoorlemmer. (2017) Altered gene expression in human placenta after suspected preterm labour. Placenta 55, pages 21-28.
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John P. Newnham, Matthew W. Kemp, Scott W. White, Catherine A. Arrese, Roger J. Hart & Jeffrey A. Keelan. (2017) Applying Precision Public Health to Prevent Preterm Birth. Frontiers in Public Health 5.
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Roberto Romero, Offer Erez, Eli Maymon & Percy Pacora. (2017) Is an episode of suspected preterm labor that subsequently leads to a term delivery benign?. American Journal of Obstetrics and Gynecology 216:2, pages 89-94.
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T Myntti, L Rahkonen, A Pätäri-Sampo, M Tikkanen, T Sorsa, J Juhila, O Helve, S Andersson, J Paavonen & V Stefanovic. (2016) Comparison of amniotic fluid matrix metalloproteinase-8 and cathelicidin in the diagnosis of intra-amniotic infection. Journal of Perinatology 36:12, pages 1049-1054.
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John P. Newnham, Jan E. Dickinson, Roger J. Hart, Craig E. Pennell, Catherine A. Arrese & Jeffrey A. Keelan. (2014) Strategies to Prevent Preterm Birth. Frontiers in Immunology 5.
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Jeffrey A. Keelan, Matthew W. Kemp, Matthew S. Payne, David Johnson, Sarah J. Stock, Masatoshi Saito, Prabhavathi Fernandes & John P. Newnham. (2014) Maternal Administration of Solithromycin, a New, Potent, Broad-Spectrum Fluoroketolide Antibiotic, Achieves Fetal and Intra-Amniotic Antimicrobial Protection in a Pregnant Sheep Model. Antimicrobial Agents and Chemotherapy 58:1, pages 447-454.
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Julia Harris & Eyal Sheiner. (2013) Does an Upper Respiratory Tract Infection During Pregnancy Affect Perinatal Outcomes? A Literature Review. Current Infectious Disease Reports 15:2, pages 143-147.
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