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Short Report

A different first-choice drug in the medical management of patent ductus arteriosus: oral paracetamol

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Pages 825-827 | Received 15 Aug 2012, Accepted 19 Nov 2012, Published online: 15 Jan 2013

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M. Noureldein, K. Hu, J. Groucutt, R. Heaver & K. Gurusamy. (2022) Paracetamol for patent ductus arteriosus in preterm infants: a UK national survey. The Journal of Maternal-Fetal & Neonatal Medicine 35:7, pages 1408-1411.
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Bharathi Balachander, Nivedita Mondal, Vishnu Bhat, Bethou Adhisivam, Mahesh Kumar, Santhosh Satheesh & Mahalakshmi Thulasingam. (2020) Comparison of efficacy of oral paracetamol versus ibuprofen for PDA closure in preterms – a prospective randomized clinical trial. The Journal of Maternal-Fetal & Neonatal Medicine 33:9, pages 1587-1592.
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Sadık Yurttutan, Aydın Bozkaya, Füheda Hüdayioglu & Mehmet Yekta Oncel. (2019) The effect of combined therapy for treatment of monotherapy-resistant PDA in preterm infants. The Journal of Maternal-Fetal & Neonatal Medicine 32:21, pages 3662-3665.
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Rania A. El-Farrash, Mohammed S. El Shimy, Abeer S. El-Sakka, Manal G. Ahmed & Dina G. Abdel-Moez. (2019) Efficacy and safety of oral paracetamol versus oral ibuprofen for closure of patent ductus arteriosus in preterm infants: a randomized controlled trial. The Journal of Maternal-Fetal & Neonatal Medicine 32:21, pages 3647-3654.
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Laura Cuzzolin, Flamina Bardanzellu & Vassilios Fanos. (2018) The dark side of ibuprofen in the treatment of patent ductus arteriosus: could paracetamol be the solution?. Expert Opinion on Drug Metabolism & Toxicology 14:8, pages 855-868.
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Asli Memisoglu, Zeynep Alp Ünkar, Nilufer Cetiner, Figen Akalın, Hulya Ozdemir, Hülya Selva Bilgen & Eren Ozek. (2016) Ductal closure with intravenous paracetamol: a new approach to patent ductus arteriosus treatment. The Journal of Maternal-Fetal & Neonatal Medicine 29:6, pages 987-990.
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Selim Sancak, Tulin Gokmen Yildirim, Sevilay Topcuoglu, Taner Yavuz, Guner Karatekin & Fahri Ovali. (2016) Oral versus intravenous paracetamol: which is better in closure of patent ductus arteriosus in very low birth weight infants?. The Journal of Maternal-Fetal & Neonatal Medicine 29:1, pages 135-139.
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Articles from other publishers (55)

Mazyar Vakiliamini, Hooman Daryoushi, Homa Babaei, Roya Chegene Lorestani, Mosayeb Rostamian, Alisha Akya, Reza Habibi & Keyghobad Ghadiri. (2023) Comparison of Therapeutic Effect and Safety of Oral and Rectal Use of Acetaminophen on Patent Ductus Arteriosus in Preterm Infants: Clinical Randomized Trial. Global Pediatric Health 10, pages 2333794X2311521.
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Bonny Jasani, Souvik Mitra & Prakeshkumar S Shah. (2022) Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants. Cochrane Database of Systematic Reviews 2022:12.
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Ayala Gover, Philip T. Levy, Avi Rotschild, Marcelo Golzman, Michal Molad, Karen Lavie-Nevo & Irena Kessel. (2022) Oral versus intravenous paracetamol for patent ductus arteriosus closure in preterm infants. Pediatric Research 92:4, pages 1146-1152.
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Aimann Surak, Amish Jain & Abbas Hyderi. (2022) Different approaches for patent ductus arteriosus in premature infants using acetaminophen. World Journal of Pediatrics 18:4, pages 243-250.
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Clyde J. Wright. (2021) Acetaminophen and the Developing Lung: Could There Be Lifelong Consequences?. The Journal of Pediatrics 235, pages 264-276.e1.
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Robert Godin, Juan Carlos Rodriguez & Doron J. Kahn. (2021) Oral Versus Intravenous Medications for Treatment of Patent Ductus Arteriosus in Preterm Neonates: A Cost-Saving Initiative. The Journal of Pediatric Pharmacology and Therapeutics 26:3, pages 291-299.
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Carlo Dani, Gianluca Lista, Silvia Bianchi, Fabio Mosca, Federico Schena, Luca Ramenghi, Enrico Zecca, Giovanni Vento, Chiara Poggi, Valentina Leonardi, Diego Minghetti, Maria Teresa Rosignoli, Fabrizio Calisti, Alessandro Comandini, Agnese Cattaneo & Paola Lipone. (2020) Intravenous paracetamol in comparison with ibuprofen for the treatment of patent ductus arteriosus in preterm infants: a randomized controlled trial. European Journal of Pediatrics 180:3, pages 807-816.
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Sarah Parkerson, Ranjit Philip, Ajay Talati & Shyam Sathanandam. (2021) Management of Patent Ductus Arteriosus in Premature Infants in 2020. Frontiers in Pediatrics 8.
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Ufuk Cakir, Cuneyt Tayman, Nazmiye Bengu Karacaglar, Esra Beser, Burak Ceran & Handan Unsal. (2020) Comparison of the effect of continuous and standard intermittent bolus paracetamol infusion on patent ductus arteriosus. European Journal of Pediatrics 180:2, pages 433-440.
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Ana García-Robles, Ana Gimeno Navarro, María del Mar Serrano Martín, María José Párraga Quiles, Anna Parra Llorca, José Luis Poveda-Andrés, Máximo Vento Torres & Marta Aguar Carrascosa. (2020) Paracetamol vs. Ibuprofen in Preterm Infants With Hemodynamically Significant Patent Ductus Arteriosus: A Non-inferiority Randomized Clinical Trial Protocol. Frontiers in Pediatrics 8.
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Ashutosh Kumar, Rahul Subhash Gosavi, Venkataseshan Sundaram, Tejo Pratap Oleti, Arun Krishnan, Sai Kiran, Jogender Kumar, Srinivas Murki, Mangalabharathi Sundaram, Shiv Sajan Saini & Sourabh Dutta. (2020) Oral Paracetamol vs Oral Ibuprofen in Patent Ductus Arteriosus: A Randomized, Controlled, Noninferiority Trial. The Journal of Pediatrics 222, pages 79-84.e2.
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Michaela Höck, Barbara Brunner, Vera Rier, Stefanie Thöni, Rudolf Trawöger, Ralf Geiger, Elisabeth Schermer, Thomas Karall & Ursula Kiechl-Kohlendorfer. (2020) Prophylactic low-dose paracetamol administration associated with lowered rate of patent ductus arteriosus in preterm infants – Impact on outcome and pain perception. Pediatrics & Neonatology 61:1, pages 84-91.
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Arne Ohlsson & Prakeshkumar S Shah. (2020) Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants. Cochrane Database of Systematic Reviews 2020:1.
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Vasudha Meena, DurgaShankar Meena, PradeepSingh Rathore, Sandeep Chaudhary & JaiPrakash Soni. (2020) Comparison of the efficacy and safety of indomethacin, ibuprofen, and paracetamol in the closure of patent ductus arteriosus in preterm neonates – A randomized controlled trial. Annals of Pediatric Cardiology 13:2, pages 130.
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Selahattin AKAR, Veysi Almaz & Mehmet Turgut. (2019) Postnatal 38.Günde Oral Parasetamol Tedavisiyle Kapanan Hemodinamik Anlamlı Patent Duktus Arteriosus OlgusuA Hemodynamically Significant Patent Ductus Arteriosus Case which was Closed at 38th Day with Oral Paracetamol Therapy. Zeynep Kamil Tıp Bülteni 50:3, pages 156-158.
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Hellmann Adrián Escobar, Gyhill Meneses-Gaviria, Nataly Revelo-Jurado, Julián Felipe Villa-Rosero, Jhon Edison Ijají Piamba, Alexander Burbano-Imbachí & Anuar Alonso Cedeño-Burbano. (2019) Tratamiento farmacológico del conducto arterioso permeable en recién nacidos prematuros. Revista de la Facultad de Medicina 67:2, pages 333-339.
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Birol Karabulut & Sebnem Paytoncu. (2019) Efficacy and Safety of Oral Paracetamol vs. Oral Ibuprofen in the Treatment of Symptomatic Patent Ductus Arteriosus in Premature Infants. Pediatric Drugs 21:2, pages 113-121.
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Tim Hundscheid, Wes Onland, Bart van Overmeire, Peter Dijk, Anton H. L. C. van Kaam, Koen P. Dijkman, Elisabeth M. W. Kooi, Eduardo Villamor, André A. Kroon, Remco Visser, Daniel C. Vijlbrief, Susanne M. de Tollenaer, Filip Cools, David van Laere, Anne-Britt Johansson, Catheline Hocq, Alexandra Zecic, Eddy Adang, Rogier Donders, Willem de Vries, Arno F. J. van Heijst & Willem P. de Boode. (2018) Early treatment versus expectative management of patent ductus arteriosus in preterm infants: a multicentre, randomised, non-inferiority trial in Europe (BeNeDuctus trial). BMC Pediatrics 18:1.
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H. Halil, M. Buyuktiryaki, F. Yavanoglu Atay, M. Yekta Oncel & N. Uras. (2018) Reopening of the ductus arteriosus in preterm infants; Clinical aspects and subsequent consequences. Journal of Neonatal-Perinatal Medicine 11:3, pages 273-279.
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Tamorah R. Lewis, Elaine L. Shelton, Sara L. Van Driest, Prince J. Kannankeril & Jeff Reese. (2018) Genetics of the patent ductus arteriosus (PDA) and pharmacogenetics of PDA treatment. Seminars in Fetal and Neonatal Medicine 23:4, pages 232-238.
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Alona Bin-Nun, Daniel Fink, Francis B. Mimouni, Nurit Algur & Cathy Hammerman. (2018) Paracetamol Serum Concentrations in Neonates Treated Enterally for Ductal Closure: A Pilot Study. The Journal of Pediatrics 198, pages 304-307.
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Selahattin AKAR, Nilüfer ÇETİNER, İbrahim Hakan BUCAK, Habip ALMIŞ & Mehmet TURGUT. (2018) Prematüre Bebeklerde Patent Duktus Arteriozusun Kapatılmasında Parasetamol Tedavisi İlk Seçenek Olabilir mi?. Zeynep Kamil Tıp Bülteni.
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B. Jasani, D.E. Weisz & P.J. McNamara. (2018) Evidence-based use of acetaminophen for hemodynamically significant ductus arteriosus in preterm infants. Seminars in Perinatology 42:4, pages 243-252.
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Arne Ohlsson & Prakeshkumar S Shah. (2018) Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants. Cochrane Database of Systematic Reviews.
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Carlo Dani, Chiara Poggi, Ilaria Cianchi, Iuri Corsini, Venturella Vangi & Simone Pratesi. (2018) Effect on cerebral oxygenation of paracetamol for patent ductus arteriosus in preterm infants. European Journal of Pediatrics 177:4, pages 533-539.
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Jesmin Hossain & Mohammad Kamrul Hassan Shabuj. (2018) Paracetamol versus Ibuprofen in the Closure of Patent Ductus Arteriosus: Proportion and Intervention Comparison Meta - Analysis. Pediatric Oncall 15:3.
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Pramod Pharande, Hadley Watson, Kenneth Tan & Arvind Sehgal. (2017) Oral Paracetamol for Patent Ductus Arteriosus Rescue Closure. Pediatric Cardiology 39:1, pages 183-190.
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Clarissa de Albuquerque Botura, Bruno Ambrósio da Rocha, Thiely Balensiefer, Franciele Queiroz Ames, Ciomar Aparecida Bersani-Amado & Roberto Kenji Nakamura Cuman. (2017) Oral pharmacological treatment for patent ductus arteriosus in premature neonates with hemodynamic repercussions. Asian Pacific Journal of Tropical Medicine 10:11, pages 1080-1083.
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Agata Jankowska, Beata Łoniewska, Agnieszka Szpiek, Agnieszka Kordek & Barbara Michalczyk. (2017) Paracetamol jako alternatywna metoda leczenia hemodynamicznie istotnego PDA u noworodków urodzonych przedwcześnie – wstępne wyniki badań. Pediatria Polska 92:3, pages 260-265.
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I. Rodríguez-Balderrama, I.B. Morales-Rodríguez, R.G. Sánchez-Cortez & M. Tijerina-Guajardo. (2017) Hemodynamically unstable ductus arteriosus treated with paracetamol in a tertiary care hospital in the northeast of Mexico. Medicina Universitaria 19:75, pages 64-68.
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Abd El-Rahman El-Mashad, Heba El-Mahdy, Doaa El Amrousy & Marwa Elgendy. (2016) Comparative study of the efficacy and safety of paracetamol, ibuprofen, and indomethacin in closure of patent ductus arteriosus in preterm neonates. European Journal of Pediatrics 176:2, pages 233-240.
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Flaminia Bardanzellu, Paola Neroni, Angelica Dessì & Vassilios Fanos. (2017) Paracetamol in Patent Ductus Arteriosus Treatment: Efficacious and Safe?. BioMed Research International 2017, pages 1-25.
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Carlo Dani, Chiara Poggi, Fabio Mosca, Federico Schena, Gianluca Lista, Luca Ramenghi, Costantino Romagnoli, Enrica Salvatori, Maria Teresa Rosignoli, Paola Lipone & Alessandro Comandini. (2016) Efficacy and safety of intravenous paracetamol in comparison to ibuprofen for the treatment of patent ductus arteriosus in preterm infants: study protocol for a randomized control trial. Trials 17:1.
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Enrico Valerio, Marta Rossella Valente, Sabrina Salvadori, Anna Chiara Frigo, Eugenio Baraldi & Paola Lago. (2016) Intravenous paracetamol for PDA closure in the preterm: a single-center experience. European Journal of Pediatrics 175:7, pages 953-966.
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Mohammad Mehdi Bagheri, Pedram Niknafs, Fatemeh Sabsevari, Mohammad Hosein Torabi, Bahareh Bahman Bijari, Elahe Noroozi & Hamid Mossavi. (2016) Comparison of Oral Acetaminophen Versus Ibuprofen in Premature Infants With Patent Ductus Arteriosus. Iranian Journal of Pediatrics 26:4.
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Sindhu Sivanandan & Ramesh Agarwal. (2016) Pharmacological Closure of Patent Ductus Arteriosus: Selecting the Agent and Route of Administration. Pediatric Drugs 18:2, pages 123-138.
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Gianluca Terrin, Francesca Conte, Mehmet Yekta Oncel, Antonella Scipione, Patrick J McNamara, Sinno Simons, Rahul Sinha, Omer Erdeve, Kadir S Tekgunduz, Mustafa Dogan, Irena Kessel, Cathy Hammerman, E Nadir, Sadik Yurttutan, Bonny Jasani, Serdar Alan, Francesco Manguso & Mario De Curtis. (2016) Paracetamol for the treatment of patent ductus arteriosus in preterm neonates: a systematic review and meta-analysis. Archives of Disease in Childhood - Fetal and Neonatal Edition 101:2, pages F127-F136.
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Mehmet Yekta Oncel. (2016) Oral medications regarding their safety and efficacy in the management of patent ductus arteriosus. World Journal of Clinical Pediatrics 5:1, pages 75.
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Daniëlla W. E. Roofthooft, Ingrid M. van Beynum, Johan C. A. de Klerk, Monique van Dijk, John N. van den Anker, Irwin K. M. Reiss, Dick Tibboel & Sinno H. P. Simons. (2015) Limited effects of intravenous paracetamol on patent ductus arteriosus in very low birth weight infants with contraindications for ibuprofen or after ibuprofen failure. European Journal of Pediatrics 174:11, pages 1433-1440.
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Kadir Şerafettin Tekgündüz, Naci Ceviz, İbrahim Caner, Haşim Olgun, Yaşar Demirelli, Canan Yolcu, İrfan Oğuz Şahin & Mustafa Kara. (2014) Intravenous paracetamol with a lower dose is also effective for the treatment of patent ductus arteriosus in pre-term infants. Cardiology in the Young 25:6, pages 1060-1064.
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Swarup Kumar Dash, Nandkishor S Kabra, Bhupendra S Avasthi, Shobha R Sharma, Phalguni Padhi & Javed Ahmed. (2015) Enteral paracetamol or intravenous indomethacin for closure of patent ductus arteriosus in preterm neonates: A randomized controlled trial. Indian Pediatrics 52:7, pages 573-578.
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Krystle M. Perez & Matthew M. Laughon. (2015) What is new for patent ductus arteriosus management in premature infants in 2015?. Current Opinion in Pediatrics 27:2, pages 158-164.
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Arne Ohlsson & Prakeshkumar S Shah. (2015) Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low-birth-weight infants. Cochrane Database of Systematic Reviews.
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Jennifer Le, Mark A. Gales & Barry J. Gales. (2014) Acetaminophen for Patent Ductus Arteriosus. Annals of Pharmacotherapy 49:2, pages 241-246.
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Alison L. Kent. 2015. Keeling’s Fetal and Neonatal Pathology. Keeling’s Fetal and Neonatal Pathology 387 412 .
Gianluca Terrin, Francesca Conte, Antonella Scipione, Erica Bacchio, Maria Giulia Conti, Rosalia Ferro, Flavia Ventriglia & Mario De Curtis. (2014) Efficacy of paracetamol for the treatment of patent ductus arteriosus in preterm neonates. Italian Journal of Pediatrics 40:1.
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Chenguang Wang, Karel Allegaert, Dick Tibboel, Meindert Danhof, Caroline D. van der Marel, Ron A.A. Mathot & Catherijne A.J. Knibbe. (2014) Population pharmacokinetics of paracetamol across the human age-range from (pre)term neonates, infants, children to adults. The Journal of Clinical Pharmacology 54:6, pages 619-629.
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Mehmet Yekta Oncel, Sadik Yurttutan, Omer Erdeve, Nurdan Uras, Nahide Altug, Serife Suna Oguz, Fuat Emre Canpolat & Ugur Dilmen. (2014) Oral Paracetamol versus Oral Ibuprofen in the Management of Patent Ductus Arteriosus in Preterm Infants: A Randomized Controlled Trial. The Journal of Pediatrics 164:3, pages 510-514.e1.
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Özmert M. A. Özdemir, Mustafa Doğan, Kazım Küçüktaşçı, Hacer Ergin & Özlem Şahin. (2013) Paracetamol Therapy for Patent Ductus Arteriosus in Premature İnfants: A Chance Before Surgical Ligation. Pediatric Cardiology 35:2, pages 276-279.
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Dan Dang, Dongxuan Wang, Chuan Zhang, Wenli Zhou, Qi Zhou & Hui Wu. (2013) Comparison of Oral Paracetamol versus Ibuprofen in Premature Infants with Patent Ductus Arteriosus: A Randomized Controlled Trial. PLoS ONE 8:11, pages e77888.
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