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International Journal of Audiology Volume 50, 2011 - Issue 2
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Research Article

Aminoglycoside antibiotics cochleotoxicity in paediatric cystic fibrosis (CF) patients: A study using extended high-frequency audiometry and distortion product otoacoustic emissions

Ghada Al-Malky *The Ear Institute, UCL, London, UKCorrespondence[email protected]
,
Ranjan Suri Department of Paediatric Respiratory Medicine, Great Ormond Street Hospital and the Portex Unit, Institute of Child Health, UCL, London, UK
,
Sally J. Dawson *The Ear Institute, UCL, London, UK
,
Tony Sirimanna Department of Audiology & Audiological Medicine, Great Ormond Street Hospital, London, UK
&
David Kemp *The Ear Institute, UCL, London, UK
Pages 112-122 | Received 08 Nov 2009, Accepted 09 Sep 2010, Published online: 25 Jan 2011

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Malcolm A. Gleser & Erika M. Zettner. (2018) Negative hearing effects of a single course of IV aminoglycoside therapy in cystic fibrosis patients. International Journal of Audiology 57:12, pages 923-930.
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L Petersen & C Rogers. (2015) Aminoglycoside-induced hearing deficits – a review of cochlear ototoxicity. South African Family Practice 57:2, pages 77-82.
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. (2013) Abstracts of the British Society of Audiology annual conference (incorporating the Experimental and Clinical Short papers meetings). International Journal of Audiology 52:4, pages 242-302.
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Articles from other publishers (33)

Adam J. Kimple, Brent A. Senior, Edward T. Naureckas, David A. Gudis, Ted Meyer, Sarah E. Hempstead, Helaine E. Resnick, Dana Albon, Wayne Barfield, Margo McKenna Benoit, Daniel M. Beswick, Eliza Callard, Shelagh Cofer, Veronica Downer, E. Claire Elson, Angela Garinis, Ashleigh Halderman, Lisa Hamburger, Meagan Helmick, Michael McCown, Cameron J. McKinzie, Hanna Phan, Kenneth Rodriguez, Ronald C. Rubenstein, Ashley Severin, Gopi Shah, Ambika Shenoy, Brittney Sprouse, Frank Virgin, Bradford A. Woodworth & Stella E. Lee. (2022) Cystic Fibrosis Foundation otolaryngology care multidisciplinary consensus recommendations. International Forum of Allergy & Rhinology 12:9, pages 1089-1103.
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Leonard P. Rybak, Debashree Mukherjea & Vickram Ramkumar. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology 732 754 .
Min Dong, Anna V Rodriguez, Chelsea A Blankenship, Gary McPhail, Alexander A Vinks & Lisa L Hunter. (2021) Pharmacokinetic modelling to predict risk of ototoxicity with intravenous tobramycin treatment in cystic fibrosis. Journal of Antimicrobial Chemotherapy 76:11, pages 2923-2931.
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Chelsea M. Blankenship, Lisa L. Hunter, M. Patrick Feeney, Madison Cox, Lindsey Bittinger, Angela C. Garinis, Li Lin, Gary McPhail & John P. Clancy. (2021) Functional Impacts of Aminoglycoside Treatment on Speech Perception and Extended High-Frequency Hearing Loss in a Pediatric Cystic Fibrosis Cohort. American Journal of Audiology 30:3S, pages 834-853.
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Sophie Magréault, Charlotte Roy, Manon Launay, Isabelle Sermet-Gaudelus & Vincent Jullien. (2021) Pharmacokinetic and Pharmacodynamic Optimization of Antibiotic Therapy in Cystic Fibrosis Patients: Current Evidences, Gaps in Knowledge and Future Directions. Clinical Pharmacokinetics 60:4, pages 409-445.
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E. Emily Harruff, Jonathan Kil, Maria Gabriela Tupayachi Ortiz, Daniel Dorgan, Raksha Jain, Elizabeth A. Poth, Robert C. Fifer, Yun Jin M. Kim, Angela G. Shoup & Patrick A. Flume. (2021) Ototoxicity in cystic fibrosis patients receiving intravenous tobramycin for acute pulmonary exacerbation. Journal of Cystic Fibrosis 20:2, pages 288-294.
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Angela Garinis, Malcolm Gleser, Alexis Johns, Erik Larsen & Jay Vachhani. (2021) Prospective cohort study of ototoxicity in persons with cystic fibrosis following a single course of intravenous tobramycin. Journal of Cystic Fibrosis 20:2, pages 278-283.
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Dagny Hemmingsen, Camilla Mikalsen, Alexander Rydland Hansen, Jon Widding Fjalstad, Niels Christian Stenklev & Claus Klingenberg. (2020) Hearing in Schoolchildren After Neonatal Exposure to a High-Dose Gentamicin Regimen. Pediatrics 145:2.
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Jacqueline M. Ogier, Paul J. Lockhart & Rachel A. Burt. (2020) Intravenously delivered aminoglycoside antibiotics, tobramycin and amikacin, are not ototoxic in mice. Hearing Research 386, pages 107870.
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Chaitanya Mamillapalli, Asmita Dhukhwa, Sandeep Sheth, Debashree Mukherjea, Leonard P. Rybak & Vickram Ramkumar. 2020. New Therapies to Prevent or Cure Auditory Disorders. New Therapies to Prevent or Cure Auditory Disorders 51 87 .
Meiyan Jiang, Hongzhe Li, Anastasiya Johnson, Takatoshi KarasawaYuan ZhangWilliam B. Meier, Farshid Taghizadeh, Allan KachelmeierPeter S. Steyger. (2019) Inflammation up-regulates cochlear expression of TRPV1 to potentiate drug-induced hearing loss. Science Advances 5:7.
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O. D. Ostroumova, E. V. Chikh, E. V. Rebrova, A. Yu. Ryazanova & A. P. Pereverzev. (2019) Drug-induced hearing loss as a manifestation of drug-induced ototoxicity. Vestnik otorinolaringologii 84:4, pages 72.
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Erika M. Zettner & Malcolm A. Gleser. (2018) Progressive Hearing Loss among Patients with Cystic Fibrosis and Parenteral Aminoglycoside Treatment. Otolaryngology–Head and Neck Surgery 159:5, pages 887-894.
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Angela C. GarinisDouglas H. KeefeLisa L. HunterDenis F. FitzpatrickDaniel B. PuttermanGarnett P. McMillanJeffrey A. GoldM. Patrick Feeney. (2018) Chirp-Evoked Otoacoustic Emissions and Middle Ear Absorbance for Monitoring Ototoxicity in Cystic Fibrosis Patients. Ear & Hearing 39:1, pages 69-84.
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Mary E. O’Sullivan, Adela Perez, Randy Lin, Autefeh Sajjadi, Anthony J. Ricci & Alan G. Cheng. (2017) Towards the Prevention of Aminoglycoside-Related Hearing Loss. Frontiers in Cellular Neuroscience 11.
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C. Behr, H. Kamp, E. Fabian, G. Krennrich, W. Mellert, E. Peter, V. Strauss, T. Walk, I. M. C. M. Rietjens & B. van Ravenzwaay. (2017) Gut microbiome-related metabolic changes in plasma of antibiotic-treated rats. Archives of Toxicology 91:10, pages 3439-3454.
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Jaynee A. Handelsman, Samya Z. Nasr, Crystal Pitts & William M. King. (2017) Prevalence of hearing and vestibular loss in cystic fibrosis patients exposed to aminoglycosides. Pediatric Pulmonology 52:9, pages 1157-1162.
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Debora T.M. Caumo, Lúcia B. Geyer, Adriane R. Teixeira & Sérgio S.M. Barreto. (2017) Hearing thresholds at high frequency in patients with cystic fibrosis: a systematic review. Brazilian Journal of Otorhinolaryngology 83:4, pages 464-474.
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Angela C. Garinis, Campbell P. Cross, Priya Srikanth, Kelly Carroll, M. Patrick Feeney, Douglas H. Keefe, Lisa L. Hunter, Daniel B. Putterman, David M. Cohen, Jeffrey A. Gold & Peter S. Steyger. (2017) The cumulative effects of intravenous antibiotic treatments on hearing in patients with cystic fibrosis. Journal of Cystic Fibrosis 16:3, pages 401-409.
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Zewen Gao, Ye Chen & Min-Xin Guan. (2017) Mitochondrial DNA mutations associated with aminoglycoside induced ototoxicity. Journal of Otology 12:1, pages 1-8.
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Daniel J. Fox, Morris D. Cooper, Cristian A. Speil, Melissa H. Roberts, Susan C. Yanik, Robert P. Meech, Tim L. Hargrove, Steven J. Verhulst, Leonard P. Rybak & Kathleen C.M. Campbell. (2016) d -Methionine reduces tobramycin-induced ototoxicity without antimicrobial interference in animal models. Journal of Cystic Fibrosis 15:4, pages 518-530.
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Joseph FosterIIII & Mustafa Tekin. (2016) Aminoglycoside induced ototoxicity associated with mitochondrial DNA mutations. Egyptian Journal of Medical Human Genetics 17:3, pages 287-293.
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Renata Almeida Araújo Silvestre, Ângela Ribas, Rogério Hammerschmidt & Adriana Bender Moreira de Lacerda. (2016) High‐frequency profile in adolescents and its relationship with the use of personal stereo devices. Jornal de Pediatria (Versão em Português) 92:2, pages 206-211.
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Renata Almeida Araújo Silvestre, Ângela Ribas, Rogério Hammerschmidt & Adriana Bender Moreira de Lacerda. (2016) High-frequency profile in adolescents and its relationship with the use of personal stereo devices. Jornal de Pediatria 92:2, pages 206-211.
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Zainab Farzal, Yann-Fuu Kou, Rachel St. John, Gopi B. Shah & Ron B. Mitchell. (2016) The role of routine hearing screening in children with cystic fibrosis on aminoglycosides: A systematic review. The Laryngoscope 126:1, pages 228-235.
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Lucia Bencke Geyer, Sergio Saldanha Menna Barreto, Liese Loureiro Weigert & Adriane Ribeiro Teixeira. (2015) High frequency hearing thresholds and product distortion otoacoustic emissions in cystic fibrosis patients. Brazilian Journal of Otorhinolaryngology 81:6, pages 589-597.
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Ghada Al-Malky, Sally J. Dawson, Tony Sirimanna, Emmanouil Bagkeris & Ranjan Suri. (2015) High-frequency audiometry reveals high prevalence of aminoglycoside ototoxicity in children with cystic fibrosis. Journal of Cystic Fibrosis 14:2, pages 248-254.
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Ghada Al-Malky, Ranjan Suri, Tony Sirimanna & Sally J. Dawson. (2014) Normal hearing in a child with the m.1555A>G mutation despite repeated exposure to aminoglycosides. Has the penetrance of this pharmacogenetic interaction been overestimated?. International Journal of Pediatric Otorhinolaryngology 78:6, pages 969-973.
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Amir Houshang Mehrparvar, Seyyed Jalil Mirmohammadi, Mohammad Hossein Davari, Mehrdad Mostaghaci, Abolfazl Mollasadeghi, Maryam Bahaloo & Seyyed Hesam Hashemi. (2014) Conventional Audiometry, Extended High-Frequency Audiometry, and DPOAE for Early Diagnosis of NIHL. Iranian Red Crescent Medical Journal 16:1.
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Daniel Peckham & Paul Whitaker. (2013) Drug induced complications; can we do more?. Journal of Cystic Fibrosis 12:6, pages 547-558.
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Veronica Melchionda, Harry Wyatt, Santino Capocci, Raul Garcia Medina, Angelita Solamalai, Sotira Katiri, Susan Hopkins, Ian Cropley & Marc Lipman. (2013) Amikacin treatment for multidrug resistant tuberculosis: how much monitoring is required?. European Respiratory Journal 42:4, pages 1148-1150.
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Jing Xie, Andra E. Talaska & Jochen Schacht. (2011) New developments in aminoglycoside therapy and ototoxicity. Hearing Research 281:1-2, pages 28-37.
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M. E. Huth, A. J. Ricci & A. G. Cheng. (2011) Mechanisms of Aminoglycoside Ototoxicity and Targets of Hair Cell Protection. International Journal of Otolaryngology 2011, pages 1-19.
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