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Journal of Pain & Palliative Care Pharmacotherapy Volume 25, 2011 - Issue 2
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ARTICLES

Methylnaltrexone for Opioid-Induced Constipation in Patients With Advanced Illness: A 3-Month Open-Label Treatment Extension Study

Arthur G. Lipman Arthur G. Lipman, PharmD, FASHP, is Professor of Pharmacotherapy, Adjunct Professor of Anesthesiology, and Director of Clinical Pharmacology at the Pain Management Center, University of Utah, Salt Lake City, Utah, USA.Correspondence[email protected]
,
Sloan Karver Sloan B. Karver, MD, FAAHPM, is Program Leader, Psychosocial and Palliative Care, Moffitt Cancer Center and Assistant Professor of Oncologic Sciences, University of South Florida, Tampa, Florida, USA; at the time of this study she was with Gulfside Regional Hospice, New Port Richey, Florida, USA.
,
Gail Austin Cooney Gail Austin Cooney, MD, FAAHPM, is Assistant Medical Director, Hospice of Palm Beach County, Inc., West Palm Beach, Florida, USA.
,
Nancy Stambler Nancy Stambler, MS, is Senior Director, Biometics.
&
Robert J. Israel Robert J. Israel, MD, is Senior Vice President for Medical Affairs, Progenics Pharmaceuticals, Inc., Tarrytown ,New York, USA.
Pages 136-145 | Accepted 16 Mar 2011, Published online: 09 Jun 2011

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Joseph V Pergolizzi Jr, Paul J Christo, Jo Ann LeQuang & Peter Magnusson. (2020) The Use of Peripheral μ-Opioid Receptor Antagonists (PAMORA) in the Management of Opioid-Induced Constipation: An Update on Their Efficacy and Safety. Drug Design, Development and Therapy 14, pages 1009-1025.
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Shilan Mozaffari, Shekoufeh Nikfar & Mohammad Abdollahi. (2018) Methylnaltrexone bromide for the treatment of opioid-induced constipation. Expert Opinion on Pharmacotherapy 19:10, pages 1127-1135.
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Lynn R Webster, Darren M Brenner, Andrew C Barrett, Craig Paterson, Enoch Bortey & William P Forbes. (2015) Analysis of opioid-mediated analgesia in Phase III studies of methylnaltrexone for opioid-induced constipation in patients with chronic noncancer pain. Journal of Pain Research 8, pages 771-780.
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Wojciech Leppert. (2015) Emerging therapies for patients with symptoms of opioid-induced bowel dysfunction. Drug Design, Development and Therapy 9, pages 2215-2231.
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Sabine Bader, Thorsten Dürk & Gerhild Becker. (2013) Methylnaltrexone for the treatment of opioid-induced constipation. Expert Review of Gastroenterology & Hepatology 7:1, pages 13-26.
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Articles from other publishers (13)

Martina Rekatsina, Antonella Paladini, Asbjørn M Drewes, Farrah Ayob, Omar Viswanath, Ivan Urits, Oscar Corli, Joseph Pergolizzi Jr & Giustino Varrassi. (2021) Efficacy and Safety of Peripherally Acting μ-Opioid Receptor Antagonist (PAMORAs) for the Management of Patients With Opioid-Induced Constipation: A Systematic Review. Cureus.
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Andrea Poon, Jakun Ing & Eric Hsu. 2021. Fundamentals of Cancer Pain Management. Fundamentals of Cancer Pain Management 97 105 .
Julia Kolbow, Christiane Modess, Danilo Wegner, Stefan Oswald, Martina Alice Maritz, Hélène Rey, Werner Weitschies & Werner Siegmund. (2016) Extended-release but not immediate-release and subcutaneous methylnaltrexone antagonizes the loperamide-induced delay of whole-gut transit time in healthy subjects. The Journal of Clinical Pharmacology 56:2, pages 239-245.
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A. Dudekula, S. Huftless & K. Bielefeldt. (2015) Colectomy for constipation: time trends and impact based on the US Nationwide Inpatient Sample, 1998–2011. Alimentary Pharmacology & Therapeutics 42:11-12, pages 1281-1293.
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David Prichard & Adil Bharucha. (2015) Management of opioid-induced constipation for people in palliative care. International Journal of Palliative Nursing 21:6, pages 272-280.
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L. Webster, W. D. Chey, J. Tack, J. Lappalainen, U. Diva & M. Sostek. (2014) Randomised clinical trial: the long‐term safety and tolerability of naloxegol in patients with pain and opioid‐induced constipation. Alimentary Pharmacology & Therapeutics 40:7, pages 771-779.
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Jeffrey K. Aronson. 2014. A worldwide yearly survey of new data in adverse drug reactions and interactions. A worldwide yearly survey of new data in adverse drug reactions and interactions 171 195 .
Marta Sobczak, Maciej Sałaga, Martin A. Storr & Jakub Fichna. (2013) Physiology, signaling, and pharmacology of opioid receptors and their ligands in the gastrointestinal tract: current concepts and future perspectives. Journal of Gastroenterology 49:1, pages 24-45.
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Carlos Centeno, Omar Carranza, Yolanda Zuriarrain, Maria Angustias Portela, Ana Larumbe, Jaume Canal & Concepción Palomar. (2013) A Prospective Study of Methylnaltrexone for Opioid-Induced Constipation in Advanced Illness: Should We Use It or Not?. Journal of Pain and Symptom Management 46:5, pages e1-e3.
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John M Hutson & Bridget R SouthwellErica N RobersonArnold Wald. 2013. Constipation: Current & Emerging Treatments. Constipation: Current & Emerging Treatments 154 167 .
Katherine Clark & David C. Currow. (2013) Constipation in Palliative Care: What Do We Use as Definitions and Outcome Measures?. Journal of Pain and Symptom Management 45:4, pages 753-762.
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Allen R. Huang & Louise Mallet. (2013) Prescribing opioids in older people. Maturitas 74:2, pages 123-129.
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Richard J. Bodnar. (2012) Endogenous opiates and behavior: 2011. Peptides 38:2, pages 463-522.
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