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Research Article

Safety and toxicological evaluation of undenatured type II collagen

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Pages 175-189 | Received 09 Dec 2009, Accepted 23 Jan 2010, Published online: 19 Feb 2010

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Yoshiaki Shiojima, Megumi Takahashi, Ryohei Takahashi, Kazuo Maruyama, Hiroyoshi Moriyama, Debasis Bagchi, Manashi Bagchi & Masanori Akanuma. (2023) Efficacy and Safety of Dietary Undenatured Type II Collagen on Joint and Motor Function in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study. Journal of the American Nutrition Association 42:3, pages 224-241.
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James P Lugo, Zainulabedin M Saiyed, Francis C Lau, Jhanna Pamela L Molina, Michael N Pakdaman, Arya Nick Shamie & Jay K Udani. (2013) Undenatured type II collagen (UC-II®) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers. Journal of the International Society of Sports Nutrition 10:1.
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Articles from other publishers (16)

Emre Sahin, Cemal Orhan, Fusun Erten, Zainulabedin Saiyed, Elnaz Karimian Azari, Shane Durkee & Kazim Sahin. (2023) The effect of oral administration of undenatured type II collagen on monosodium iodoacetate-induced osteoarthritis in young and old rats. Scientific Reports 13:1.
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O. A. Gromova, I. Y. Torshin & A. M. Lila. (2022) On the use of chondroitin sulfate, glucosamine sulfate and undenatured type II collagen for back and limb pain and osteoarthritis. Neurology, Neuropsychiatry, Psychosomatics 14:6, pages 122-130.
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O. A. Gromova, I. Yu. Torshin & A. M. Lila. (2022) Molecular Mechanisms of Action of Undenatured Type II Collagen: Experimental and Clinical Evidence. Modern Rheumatology Journal 16:5, pages 108-113.
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Jessica L Varney, Jason W Fowler & Craig N Coon. (2022) Impact of supplemented undenatured type II collagen on pain and mobility in healthy Labrador Retrievers during an exercise regimen. Translational Animal Science 6:3.
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R.M. Abdel-Rahman, V. Vishakha, I. Kelnar, J. Jancar & A.M. Abdel-Mohsen. (2022) Synergistic performance of collagen-g-chitosan-glucan fiber biohybrid scaffold with tunable properties. International Journal of Biological Macromolecules 202, pages 671-680.
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Ting-Yu Chang, Kuo-Cheng Lan, Kuo-Tai Hua & Shing-Hwa Liu. (2022) In vitro genotoxicity assessment and 28-day repeated dose oral toxicity study of steady-calcium formula in rats. Toxicology Reports 9, pages 834-841.
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Ali Mobasheri, Armaghan Mahmoudian, Ursule Kalvaityte, Ilona Uzieliene, Christina E. Larder, Michèle M. Iskandar, Stan Kubow, Paulo Cesar Hamdan, Cyro Scala de AlmeidaJrJr, Lacey J. Favazzo, Luc J.C. van Loon, Pieter J. Emans, Pérola G. Plapler & Michael J. Zuscik. (2021) A White Paper on Collagen Hydrolyzates and Ultrahydrolyzates: Potential Supplements to Support Joint Health in Osteoarthritis?. Current Rheumatology Reports 23:11.
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Ramesh C. Gupta, Sanyasi R. Kalidindi, Robin B. Doss, Rajiv Lall, Ajay Srivastava & Anita Sinha. 2021. Nutraceuticals. Nutraceuticals 193 214 .
A.M. Abdel-Mohsen, J. Frankova, Rasha M. Abdel-Rahman, A.A. Salem, N.M. Sahffie, I. Kubena & J. Jancar. (2020) Chitosan-glucan complex hollow fibers reinforced collagen wound dressing embedded with aloe vera. II. Multifunctional properties to promote cutaneous wound healing. International Journal of Pharmaceutics 582, pages 119349.
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Hasan Gencoglu, Cemal Orhan, Emre Sahin & Kazim Sahin. (2020) Undenatured Type II Collagen (UC-II) in Joint Health and Disease: A Review on the Current Knowledge of Companion Animals. Animals 10:4, pages 697.
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A.M. Abdel-Mohsen, R.M. Abdel-Rahman, I. Kubena, L. Kobera, Z. Spotz, M. Zboncak, R. Prikryl, J. Brus & J. Jancar. (2020) Chitosan-glucan complex hollow fibers reinforced collagen wound dressing embedded with aloe vera. Part I: Preparation and characterization. Carbohydrate Polymers 230, pages 115708.
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Ramesh C. Gupta, Robin B. Doss, Rajiv Lall, Ajay Srivastava & Anita Sinha. 2019. Nutraceuticals in Veterinary Medicine. Nutraceuticals in Veterinary Medicine 365 381 .
C.M. Bagi, E.R. Berryman, S. Teo & N.E. Lane. (2017) Oral administration of undenatured native chicken type II collagen (UC-II) diminished deterioration of articular cartilage in a rat model of osteoarthritis (OA). Osteoarthritis and Cartilage 25:12, pages 2080-2090.
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ANA CLAUDIA TOMAZ ROBLES, ROSANE LOPES DE ALMEIDA, ROGERIO TIYO & GISELY CRISTINY LOPES. (2016) ANÁLISE DO CONTEÚDO DAS INFORMAÇÕES TECNICO-CIENTÍFICAS DE FOLDERS PUBLICITARIOS DE ATIVOS MAGISTRAIS. Infarma - Ciências Farmacêuticas 28:4, pages 247-252.
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Ramesh C. Gupta. 2016. Nutraceuticals. Nutraceuticals 161 176 .
Sona Jantova, Dusan Bakos, Lucia Birosova & Patrik Matejov. (2015) Biological properties of a novel coladerm-beta glucan membrane.In vitro assessment using human fibroblasts. Biomedical Papers 159:1, pages 067-076.
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