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Toxicology Mechanisms and Methods Volume 21, 2011 - Issue 1
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Research Article

The oxime pro-2-PAM provides minimal protection against the CNS effects of the nerve agents sarin, cyclosarin, and VX in guinea pigs

Tsung-Ming ShihResearch and Analytical Toxicology Divisions, US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010–5400, USACorrespondence[email protected]
,
John A. GuariscoResearch and Analytical Toxicology Divisions, US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010–5400, USA
,
Todd M. MyersResearch and Analytical Toxicology Divisions, US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010–5400, USA
,
Robert K. KanResearch and Analytical Toxicology Divisions, US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010–5400, USA
&
John H. McDonoughResearch and Analytical Toxicology Divisions, US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010–5400, USA
Pages 53-62 | Received 29 Jul 2010, Accepted 04 Sep 2010, Published online: 30 Nov 2010

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Patrick Masson. (2016) Novel approaches in prophylaxis/pretreatment and treatment of organophosphorus poisoning. Phosphorus, Sulfur, and Silicon and the Related Elements 191:11-12, pages 1433-1443.
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Victor A. Voicu, Andrei Valentin Medvedovici, Koichi Sakurada, Hikoto Ohta, Flavian Ștefan Rădulescu & Dalia Simona Miron. (2016) The forgotten or underestimated relevance of biopharmaceutical-based assessments for the oral absorption studies of oxime reactivators. Expert Opinion on Drug Metabolism & Toxicology 12:7, pages 743-752.
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Articles from other publishers (24)

Aishwarya Sriraman. (2023) Optimizing chemical agent medical countermeasures in the Strategic National Stockpile. Journal of Science Policy & Governance 22:03.
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Lukas Gorecki, Ondrej Soukup & Jan Korabecny. (2022) Countermeasures in organophosphorus intoxication: pitfalls and prospects. Trends in Pharmacological Sciences 43:7, pages 593-606.
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Kristy L. Meads, Thaddeus P. Thomas, Jeffrey L. Langston, Todd M. Myers & Tsung-Ming Shih. (2021) Evaluation of adenosine A1 receptor agonists as neuroprotective countermeasures against Soman intoxication in rats. Toxicology and Applied Pharmacology 416, pages 115466.
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Libin Zhang, Hironobu Murata, Gabriel Amitai, Paige N. Smith, Krzysztof Matyjaszewski & Alan J. Russell. (2020) Catalytic Detoxification of Organophosphorus Nerve Agents by Butyrylcholinesterase-Polymer-Oxime Bioscavengers. Biomacromolecules 21:9, pages 3867-3877.
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Janice E. Chambers, Mary B. Dail & Edward C. Meek. (2020) Oxime-mediated reactivation of organophosphate-inhibited acetylcholinesterase with emphasis on centrally-active oximes. Neuropharmacology 175, pages 108201.
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Mohd Nor Faiz Norrrahim, Mas Amira Idayu Abdul Razak, Noor Aisyah Ahmad Shah, Herdawati Kasim, Wan Yusmawati Wan Yusoff, Norhana Abdul Halim, Siti Aminah Mohd Nor, Siti Hasnawati Jamal, Keat Khim Ong, Wan Md Zin Wan Yunus, Victor Feizal Knight & Noor Azilah Mohd Kasim. (2020) Recent developments on oximes to improve the blood brain barrier penetration for the treatment of organophosphorus poisoning: a review. RSC Advances 10:8, pages 4465-4489.
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Milan Jokanović, Miloš P. Stojiljković, Bojan Kovač & Dragana Ristić. 2020. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents 1145 1159 .
Libin Zhang, Stefanie L. Baker, Hironobu Murata, Nicholas Harris, Weihang Ji, Gabriel Amitai, Krzysztof Matyjaszewski & Alan J. Russell. (2019) Tuning Butyrylcholinesterase Inactivation and Reactivation by Polymer‐Based Protein Engineering. Advanced Science 7:1.
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Alciene Almeida Siqueira, Alexandre Frinhani Cunha, Graziany Leite Moreira Marques, Igor Simões Assunção Felippe, Vitor Sampaio Minassa, Thallis Coelho da Silva Gramelich, Maria Aparecida Cicilini, Tamara Andrea Alarcon, Rita Gomes Wanderley Pires, Karla Nivea Sampaio & Vanessa Beijamini. (2019) Atropine counteracts the depressive-like behaviour elicited by acute exposure to commercial chlorpyrifos in rats. Neurotoxicology and Teratology 71, pages 6-15.
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Gideon F. Meerhoff, Stefanie M. Vester, Peter Hesseling, Steven D. Klaassen, Alex S. Cornelissen, Paul J. Lucassen & Marloes J.A. Joosen. (2018) Potentiation of antiseizure and neuroprotective efficacy of standard nerve agent treatment by addition of tariquidar. NeuroToxicology 68, pages 167-176.
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Ronald B Pringle, Edward C Meek, Howard W Chambers & Janice E Chambers. (2018) Neuroprotection From Organophosphate-Induced Damage by Novel Phenoxyalkyl Pyridinium Oximes in Rat Brain. Toxicological Sciences.
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Erika A. Scholl, Stephanie M. Miller-Smith, Steven L. Bealer, Mark J. Lehmkuhle, Jeffrey J. Ekstrand, F. Edward Dudek & John H. McDonough. (2018) Age-dependent behaviors, seizure severity and neuronal damage in response to nerve agents or the organophosphate DFP in immature and adult rats. NeuroToxicology 66, pages 10-21.
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Jennifer L. Winkler, Jacob W. Skovira & Robert K. Kan. (2017) Anticonvulsant efficacy of antihistamine cyproheptadine in rats exposed to the chemical warfare nerve agent soman. NeuroToxicology 58, pages 153-160.
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Peter Buchwald & Nicholas Bodor. (2016) Brain-Targeting Chemical Delivery Systems and Their Cyclodextrin-Based Formulations in Light of the Contributions of Marcus E. Brewster. Journal of Pharmaceutical Sciences 105:9, pages 2589-2600.
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Hayden R. Schmidt, Zoran Radić, Palmer Taylor & Erica A. Fradinger. (2015) Quaternary and tertiary aldoxime antidotes for organophosphate exposure in a zebrafish model system. Toxicology and Applied Pharmacology 284:2, pages 197-203.
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Milan Jokanović. 2015. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents 1057 1070 .
Randall L. Woltjer. 2015. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents 741 749 .
Franz Worek, Thomas Seeger, Georg Reiter, Moshe Goldsmith, Yacov Ashani, Haim Leader, Joel L. Sussman, Nidhi Aggarwal, Horst Thiermann & Dan S. Tawfik. (2014) Post-exposure treatment of VX poisoned guinea pigs with the engineered phosphotriesterase mutant C23: A proof-of-concept study. Toxicology Letters 231:1, pages 45-54.
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Franz Worek, Thomas Seeger, Moshe Goldsmith, Yacov Ashani, Haim Leader, Joel S. Sussman, Dan Tawfik, Horst Thiermann & Timo Wille. (2014) Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro. Archives of Toxicology 88:6, pages 1257-1266.
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Rakesh K. Sit, Valery V. Fokin, Gabriel Amitai, K. Barry Sharpless, Palmer Taylor & Zoran Radić. (2014) Imidazole Aldoximes Effective in Assisting Butyrylcholinesterase Catalysis of Organophosphate Detoxification. Journal of Medicinal Chemistry 57:4, pages 1378-1389.
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Mohammd Moshiri, Emadodin Darchini-Maragheh & Mahdi Balali-Mood. (2012) Advances in toxicology and medical treatment of chemical warfare nerve agents. DARU Journal of Pharmaceutical Sciences 20:1.
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Marcio de Araujo Furtado, Franco Rossetti, Soma Chanda & Debra Yourick. (2012) Exposure to nerve agents: From status epilepticus to neuroinflammation, brain damage, neurogenesis and epilepsy. NeuroToxicology 33:6, pages 1476-1490.
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Nicholas Bodor & Peter Buchwald. 2012. Retrometabolic Drug Design and Targeting. Retrometabolic Drug Design and Targeting 259 393 .
Farhat A. Khan, Amy J. Campbell, Benjamin Hoyt, Christine Herdman, Therese Ku, Sonia Thangavelu & Richard K. Gordon. (2011) Oxidative mechanisms for the biotransformation of 1-methyl-1,6-dihydropyridine-2-carbaldoxime to pralidoxime chloride. Life Sciences 89:25-26, pages 911-917.
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