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Toxicology Mechanisms and Methods Volume 24, 2014 - Issue 6
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Research Article

Stimulation of central A1 adenosine receptors suppresses seizure and neuropathology in a soman nerve agent seizure rat model

Thaddeus P. ThomasUS Army Medical Research Institute of Chemical Defense;US Army Research Laboratory Aberdeen Proving Ground, MDUSA
&
Tsung-Ming ShihUS Army Medical Research Institute of Chemical DefenseCorrespondence[email protected]
Pages 385-395 | Received 06 Feb 2014, Accepted 27 Apr 2014, Published online: 22 May 2014

Citations (10)

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Patrick Masson. (2016) Novel approaches in prophylaxis/pretreatment and treatment of organophosphorus poisoning. Phosphorus, Sulfur, and Silicon and the Related Elements 191:11-12, pages 1433-1443.
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Cindy Acon-Chen, Jeffrey A. Koenig, Garrett R. Smith, Amber R. Truitt, Thaddeus P. Thomas & Tsung-Ming Shih. (2016) Evaluation of acetylcholine, seizure activity and neuropathology following high-dose nerve agent exposure and delayed neuroprotective treatment drugs in freely moving rats. Toxicology Mechanisms and Methods 26:5, pages 378-388.
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Articles from other publishers (8)

Tsung-Ming Shih. (2023) A novel genetically modified mouse seizure model for evaluating anticonvulsive and neuroprotective efficacy of an A1 adenosine receptor agonist following soman intoxication. Toxicology and Applied Pharmacology 464, pages 116437.
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Meghan Gage, Nikhil S. Rao, Manikandan Samidurai, Marson Putra, Suraj S. Vasanthi, Christina Meyer, Chong Wang & Thimmasettappa Thippeswamy. (2022) Soman (GD) Rat Model to Mimic Civilian Exposure to Nerve Agent: Mortality, Video-EEG Based Status Epilepticus Severity, Sex Differences, Spontaneously Recurring Seizures, and Brain Pathology. Frontiers in Cellular Neuroscience 15.
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Tara N. Loughery, Kimberly A. Whitten, Cindy Acon-Chen & Tsung-Ming Shih. (2021) Intramuscularly administered A1 adenosine receptor agonists as delayed treatment for organophosphorus nerve agent-induced Status Epilepticus. Toxicology and Applied Pharmacology 419, pages 115515.
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Kristy L. Meads, Thaddeus P. Thomas, Jeffrey L. Langston, Todd M. Myers & Tsung-Ming Shih. (2021) Evaluation of adenosine A1 receptor agonists as neuroprotective countermeasures against Soman intoxication in rats. Toxicology and Applied Pharmacology 416, pages 115466.
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Thaddeus P. Thomas, Amy Wegener & Tsung-Ming Shih. (2019) In Vivo Evaluation of A1 Adenosine Agonists as Novel Anticonvulsant Medical Countermeasures to Nerve Agent Intoxication in a Rat Soman Seizure Model. Neurotoxicity Research 36:2, pages 323-333.
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Ariana Beste, DeCarlos E. Taylor, Tsung-Ming Shih & Thaddeus P. Thomas. (2018) Mechanisms of acetylcholinesterase protection against sarin and soman by adenosine A1 receptor agonist N6-cyclopentyladenosine. Computational Biology and Chemistry 75, pages 74-81.
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Karina Vargas-Sánchez, Maria Mogilevskaya, John Rodríguez-Pérez, María G. Rubiano, José J. Javela & Rodrigo E. González-Reyes. (2018) Astroglial role in the pathophysiology of status epilepticus : an overview . Oncotarget 9:42, pages 26954-26976.
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Hilary S. McCarren & John H. McDonoughJr.Jr.. (2016) Anticonvulsant discovery through animal models of status epilepticus induced by organophosphorus nerve agents and pesticides. Annals of the New York Academy of Sciences 1374:1, pages 144-150.
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