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Research Article

Toxicity of brominated flame retardants, BDE-47 and BDE-99 stems from impaired mitochondrial bioenergetics

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Pages 34-41 | Received 04 Aug 2014, Accepted 04 Oct 2014, Published online: 30 Oct 2014

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Lilian C Pereira, Alecsandra O Souza, Maria J Tasso, Alana M C Oliveira, Filipe V Duarte, Carlos M Palmeira & Daniel J Dorta. (2017) Exposure to decabromodiphenyl ether (BDE-209) produces mitochondrial dysfunction in rat liver and cell death. Journal of Toxicology and Environmental Health, Part A 80:19-21, pages 1129-1144.
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Dave Arthur R. Robledo, Maricar S. Prudente, Socorro E. Aguja & Hisato Iwata. (2023) A meta-analysis of randomized controlled studies on the hepatoxicity induced by polybrominated diphenyl ethers (PBDEs) in rats and mice. Current Research in Toxicology 5, pages 100131.
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Benjamin M Dungar, Chad D Schupbach, Jessie R Jacobson & Phillip G Kopf. (2021) Adrenal Corticosteroid Perturbation by the Endocrine Disruptor BDE-47 in a Human Adrenocortical Cell Line and Male Rats. Endocrinology 162:11.
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Boyuan Wang, Ying Guo, Bin Zhou, Hui Zhang, Xinyi Cui, Yu Sun & You Wang. (2021) A possible speculation on the involvement of ROS and lysosomes mediated mitochondrial pathway in apoptosis of rotifer Brachionus plicatilis with BDE-47 exposure. Science of The Total Environment 787, pages 147315.
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Honglin Huang, Lili Lv, Dan Wang, Bin Guo, Jitao Lv, Lei Luo, Bei Wen & Yuehui Kang. (2021) Biochemical and molecular responses of maize (Zea mays L.) to 1,2-dibromo-4-(1,2 dibromoethyl) cyclohexane (TBECH) diastereomers: Oxidative stress, DNA damage, antioxidant enzyme gene expression and diversity of root exudates. Science of The Total Environment 753, pages 141872.
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Juan Zhuang, Zheng-jun Pan, Mengqiu-Li, Fa-shui Hong, Chuan-kun Zhu, Nan Wu, Guoliang Chang, Hui Wang & Xiang-xiang Zhao. (2020) BDE-47 induced apoptosis in zebrafish embryos through mitochondrial ROS-mediated JNK signaling. Chemosphere 258, pages 127385.
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Feng Chen, Li Feng, Yuan-lin Zheng, Jun Lu, Shao-hua Fan, Qu Shan, Gui-hong Zheng, Yong-Jian Wang, Dong-mei Wu, Meng-qiu Li, Qing-qing Wang & Zi-feng Zhang. (2020) 2, 2′, 4, 4′-tetrabromodiphenyl ether (BDE-47) induces mitochondrial dysfunction and related liver injury via eliciting miR-34a-5p-mediated mitophagy impairment. Environmental Pollution 258, pages 113693.
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Xiumei Han, Yanchen Wang, Ting Chen, Mark J. Wilson, Feng Pan, Xian Wu, Can Rui, Daozhen Chen, Qiuqin Tang & Wei Wu. (2019) Inhibition of progesterone biosynthesis induced by deca-brominated diphenyl ether (BDE-209) in mouse Leydig tumor cell (MLTC-1). Toxicology in Vitro 60, pages 383-388.
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Zhi Tang, Yunxiu Li, Yousheng Jiang, Jinquan Cheng, Shunqing Xu & Jianqing Zhang. (2019) Cellular metabolomics reveals glutamate and pyrimidine metabolism pathway alterations induced by BDE-47 in human neuroblastoma SK-N-SH cells. Ecotoxicology and Environmental Safety 182, pages 109427.
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Raissa S. Ferrari, Alecsandra O. de Souza, Daniel L. R. Annunciação, Fernando F. Sodré & Daniel J. Dorta. (2019) Assessing Surface Sediment Contamination by PBDE in a Recharge Point of Guarani Aquifer in Ribeirão Preto, Brazil. Water 11:8, pages 1601.
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Xinguo Zhao, Xingguan Lin, Keming Qu, Bin Xia, Xuemei Sun & Bijuan Chen. (2019) Toxicity of BDE-47, BDE-99 and BDE-153 on swimming behavior of the unicellular marine microalgae Platymonas subcordiformis and implications for seawater quality assessment. Ecotoxicology and Environmental Safety 174, pages 408-416.
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Cristobal Espinosa Ruiz, Simona Manuguerra, Alberto Cuesta, Maria Angeles Esteban, Andrea Santulli & Concetta M. Messina. (2019) Sub-lethal doses of polybrominated diphenyl ethers affect some biomarkers involved in energy balance and cell cycle, via oxidative stress in the marine fish cell line SAF-1. Aquatic Toxicology 210, pages 1-10.
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Cristobal Espinosa Ruiz, Simona Manuguerra, Alberto Cuesta, Andrea Santulli & Concetta Messina. (2019) Oxidative Stress, Induced by Sub-Lethal Doses of BDE 209, Promotes Energy Management and Cell Cycle Modulation in the Marine Fish Cell Line SAF-1. International Journal of Environmental Research and Public Health 16:3, pages 474.
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Chunxue Yang, Chi-Ming Wong, Juntong Wei, Arthur C.K. Chung & Zongwei Cai. (2018) The brominated flame retardant BDE 47 upregulates purine metabolism and mitochondrial respiration to promote adipocyte differentiation. Science of The Total Environment 644, pages 1312-1322.
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Nianwei Qiu, Renjun Wang, Yuan Sun, Xiushun Wang, Dacheng Jiang, Yuting Meng & Feng Zhou. (2018) Toxic effects and mechanism of 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) on Lemna minor. Chemosphere 193, pages 711-719.
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Sabrina Tait, Monia Perugini & Cinzia La Rocca. (2017) Relative toxicological ranking of eight polybrominated diphenyl ether congeners using cytotoxicity, chemical properties and exposure data. Food and Chemical Toxicology 108, pages 74-84.
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Lilian Cristina Pereira, Filipe Valente Duarte, Ana Teresa Inácio Ferreira Varela, Anabela Pinto Rolo, Carlos Manuel Marques Palmeira & Daniel Junqueira Dorta. (2017) Exposure to BDE-153 induces autophagy in HepG2 cells. Toxicology in Vitro 42, pages 61-68.
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Shelagh K. Genuis, Detlef Birkholz & Stephen J. Genuis. (2017) Human Excretion of Polybrominated Diphenyl Ether Flame Retardants: Blood, Urine, and Sweat Study. BioMed Research International 2017, pages 1-14.
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Alecsandra O. Souza, Maria J. Tasso, Alana M. C. Oliveira, Lilian C. Pereira, Filipe V. Duarte, Danielle P. Oliveira, Carlos M. Palmeira & Daniel J. Dorta. (2016) Evaluation of Polybrominated Diphenyl Ether Toxicity on HepG2 Cells - Hexabrominated Congener (BDE-154) Is Less Toxic than Tetrabrominated Congener (BDE-47). Basic & Clinical Pharmacology & Toxicology 119:5, pages 485-497.
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Lílian Cristina Pereira, Alecsandra Oliveira de Souza, Gabriela Meireles, Mariana Furio Franco-Bernardes, Maria Júlia Tasso, Vítor Bruno, Daniel Junqueira Dorta & Danielle Palma de Oliveira. (2016) Comparative Study of Genotoxicity Induced by Six Different PBDEs. Basic & Clinical Pharmacology & Toxicology 119:4, pages 396-404.
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Lílian Cristina Pereira, Alecsandra Oliveira de Souza, Mariana Furio Franco Bernardes, Murilo Pazin, Maria Júlia Tasso, Paulo Henrique Pereira & Daniel Junqueira Dorta. (2015) A perspective on the potential risks of emerging contaminants to human and environmental health. Environmental Science and Pollution Research 22:18, pages 13800-13823.
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Lucio G. Costa, Claudia Pellacani, Khoi Dao, Terrance J. Kavanagh & Pamela J. Roque. (2015) The brominated flame retardant BDE-47 causes oxidative stress and apoptotic cell death in vitro and in vivo in mice. NeuroToxicology 48, pages 68-76.
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