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Research Articles

Deoxynivalenol induces cytotoxicity and genotoxicity in animal primary cell culture

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Pages 184-191 | Received 17 Nov 2014, Accepted 02 Jan 2015, Published online: 11 Feb 2015

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Sevcan Mamur, Deniz Yuzbasioglu, Serkan Yılmaz, Esra Erikel & Fatma Unal. (2018) Assessment of cytotoxic and genotoxic effects of enniatin-A in vitro. Food Additives & Contaminants: Part A 35:8, pages 1633-1644.
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Ana-Marija Domijan, Klara Hercog, Martina Štampar, Goran Gajski, Marko Gerić, Marijana Sokolović & Bojana Žegura. (2023) Impact of Deoxynivalenol and Zearalenone as Single and Combined Treatment on DNA, Cell Cycle and Cell Proliferation in HepG2 Cells. International Journal of Molecular Sciences 24:4, pages 4082.
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Xiaoxiao Mao, Jie Li, Xin Xie, Shuang Chen, Qiang Huang, Peiqiang Mu, Jun Jiang & Yiqun Deng. (2022) Deoxynivalenol induces caspase-3/GSDME-dependent pyroptosis and inflammation in mouse liver and HepaRG cells. Archives of Toxicology 96:11, pages 3091-3112.
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Shuangxiu Wan, Na Sun, Hongquan Li, Ajab Khan, Xiaozhong Zheng, Yaogui Sun & Ruiwen Fan. (2022) Deoxynivalenol damages the intestinal barrier and biota of the broiler chickens. BMC Veterinary Research 18:1.
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Shunwang Zhao, Jian Zhang, Xueqian Sun, Chamba Yangzom & Peng Shang. (2022) Mitochondrial calcium uniporter involved in foodborne mycotoxin-induced hepatotoxicity. Ecotoxicology and Environmental Safety 237, pages 113535.
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Manoj B. Kudupoje, Venkataramaiah Malathi & Alexandros Yiannikouris. (2022) Impact of a Natural Fusarial Multi-Mycotoxin Challenge on Broiler Chickens and Mitigation Properties Provided by a Yeast Cell Wall Extract and a Postbiotic Yeast Cell Wall-Based Blend. Toxins 14:5, pages 315.
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Luca Lo Verso, Kristina Dumont, Martin Lessard, Karoline Lauzon, Chantale Provost, Carl A Gagnon, Younes Chorfi & Frédéric Guay. (2021) The administration of diets contaminated with low to intermediate doses of deoxynivalenol and supplemented with antioxidants and binding agents slightly affects the growth, antioxidant status, and vaccine response in weanling pigs. Journal of Animal Science 99:9.
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Rufeng Xue, Shuhang Li, Huijuan Zou, Dongmei Ji, Mingrong Lv, Ping Zhou, Zhaolian Wei, Zhiguo Zhang & Yunxia Cao. (2021) Melatonin alleviates deoxynivalenol-induced apoptosis of human granulosa cells by reducing mutually accentuated FOXO1 and ER stress. Biology of Reproduction 105:2, pages 554-566.
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Andressa Cunha Lemos, Verônica Simões de Borba & Eliana Badiale-Furlong. (2021) The impact of wheat-based food processing on the level of trichothecenes and their modified forms. Trends in Food Science & Technology 111, pages 89-99.
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Yuyun He, Xiaoyao Yin, Jingjing Dong, Qing Yang, Yongning Wu & Zhiyong Gong. (2021) Transcriptome Analysis of Caco-2 Cells upon the Exposure of Mycotoxin Deoxynivalenol and Its Acetylated Derivatives. Toxins 13:2, pages 167.
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Li Cao, Yunjing Jiang, Lei Zhu, Wei Xu, Xiaoyan Chu, Yafei Zhang, Sajid Ur Rahman, Shibin Feng, Yu Li, Jinjie Wu & Xichun Wang. (2021) Deoxynivalenol Induces Caspase-8-Mediated Apoptosis through the Mitochondrial Pathway in Hippocampal Nerve Cells of Piglet. Toxins 13:2, pages 73.
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Sakshi Mishra, Aman Divakar, Sonal Srivastava, Jayant Dewangan, Divyansh Sharma, Somya Asthana, Swati Chaturvedi, Muhammad Wahajuddin, Sadan Kumar & Srikanta Kumar Rath. (2020) N-acetyl-cysteine in combination with celecoxib inhibits Deoxynivalenol induced skin tumor initiation via induction of autophagic pathways in swiss mice. Free Radical Biology and Medicine 156, pages 70-82.
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Simeng Liao, Shengguo Tang, Bie Tan, Jianjun Li, Ming Qi, Zhijuan Cui, Andong Zha, Yanan Wang, Yulong Yin, Peng Sun & Yulong Tang. (2020) Chloroquine Improves Deoxynivalenol-Induced Inflammatory Response and Intestinal Mucosal Damage in Piglets. Oxidative Medicine and Cellular Longevity 2020, pages 1-13.
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Ana Juan-García, Saverio Carbone, Maissa Ben-Mahmoud, Gianni Sagratini & Jordi Mañes. (2020) Beauvericin and ochratoxin A mycotoxins individually and combined in HepG2 cells alter lipid peroxidation, levels of reactive oxygen species and glutathione. Food and Chemical Toxicology 139, pages 111247.
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Denisa Perez Gaudio, Joaquín Mozo, Guadalupe Martínez, MaríaB Fernández Paggi, JulietaM Decundo, Agustina Romanelli, Susana Dieguez & Alejandro Soraci. (2020) Fosfomycin protects intestinal cells from nuclear changes suggestive of deoxynivalenol-induced apoptosis. Journal of Reports in Pharmaceutical Sciences 9:2, pages 209.
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Muhsin Aydın & Eyyüp Rencüzoğulları. (2019) Genotoxic and mutagenic effects of mycotoxins: a review. Commagene Journal of Biology.
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Yue Huang, Shuang Liu, Wei Hou, Peng Xiao, Nianjun Chen, Pei Qiu, Zhao Peng, Yuxiao Liao, Liangliang Wang, Dan Li, Liegang Liu & Wei Yang. (2019) High contamination levels of deoxynivalenol-induced erythrocyte damage in different models. Trends in Food Science & Technology 86, pages 41-50.
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Jessica Audrey Feijó Corrêa, Paloma Bianca Orso, Keliani Bordin, Raquel Vaz Hara & Fernando Bittencourt Luciano. (2018) Toxicological effects of fumonisin B1 in combination with other Fusarium toxins. Food and Chemical Toxicology 121, pages 483-494.
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Chen Huang, Pei Wu, Wei-Dan Jiang, Yang Liu, Yun-Yun Zeng, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Yong-An Zhang, Xiao-Qiu Zhou & Lin Feng. (2018) Deoxynivalenol decreased the growth performance and impaired intestinal physical barrier in juvenile grass carp ( Ctenopharyngodon idella ). Fish & Shellfish Immunology 80, pages 376-391.
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Ana Juan-García, Mercedes Taroncher, Guillermina Font & María-José Ruiz. (2018) Micronucleus induction and cell cycle alterations produced by deoxynivalenol and its acetylated derivatives in individual and combined exposure on HepG2 cells. Food and Chemical Toxicology 118, pages 719-725.
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Zhihua Ren, Huidan Deng, Youtian Deng, Zhen Liang, Junliang Deng, Zhicai Zuo, Yanchun Hu, Liuhong Shen, Shumin Yu & Suizhong Cao. (2017) Combined effects of deoxynivalenol and zearalenone on oxidative injury and apoptosis in porcine splenic lymphocytes in vitro. Experimental and Toxicologic Pathology 69:8, pages 612-617.
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Helle Katrine Knutsen, Jan Alexander, Lars Barregård, Margherita Bignami, Beat Brüschweiler, Sandra Ceccatelli, Bruce Cottrill, Michael Dinovi, Bettina Grasl‐Kraupp, Christer Hogstrand, Laurentius (Ron) Hoogenboom, Carlo Stefano Nebbia, Isabelle P Oswald, Annette Petersen, Martin Rose, Alain‐Claude Roudot, Tanja Schwerdtle, Christiane Vleminckx, Günter Vollmer, Heather Wallace, Sarah De Saeger, Gunnar Sundstøl Eriksen, Peter Farmer, Jean‐Marc Fremy, Yun Yun Gong, Karsten Meyer, Hanspeter Naegeli, Dominique Parent‐Massin, Ivonne Rietjens, Hans van Egmond, Andrea Altieri, Mari Eskola, Petra Gergelova, Luisa Ramos Bordajandi, Bistra Benkova, Barbara Dörr, Athanasios Gkrillas, Nicklas Gustavsson, Mathijs van Manen & Lutz Edler. (2017) Risks to human and animal health related to the presence of deoxynivalenol and its acetylated and modified forms in food and feed. EFSA Journal 15:9.
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Boyang Zhang, Kunlun Huang, Liye Zhu, Yunbo Luo & Wentao Xu. (2017) Precision toxicology based on single cell sequencing: an evolving trend in toxicological evaluations and mechanism exploration. Archives of Toxicology 91:7, pages 2539-2549.
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Delphine Payros, Ulrich Dobrindt, Patricia Martin, Thomas Secher, Ana Paula F. L. Bracarense, Michèle Boury, Joelle Laffitte, Philippe Pinton, Eric Oswald & Isabelle P. Oswald. (2017) The Food Contaminant Deoxynivalenol Exacerbates the Genotoxicity of Gut Microbiota. mBio 8:2.
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Zhao Peng, Liangkai Chen, Andreas K. Nüssler, Liegang Liu & Wei Yang. (2017) Current sights for mechanisms of deoxynivalenol-induced hepatotoxicity and prospective views for future scientific research: A mini review. Journal of Applied Toxicology 37:5, pages 518-529.
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Delphine Payros, Imourana Alassane-Kpembi, Alix Pierron, Nicolas Loiseau, Philippe Pinton & Isabelle P. Oswald. (2016) Toxicology of deoxynivalenol and its acetylated and modified forms. Archives of Toxicology 90:12, pages 2931-2957.
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Xichun Wang, Wei Xu, Mengxue Fan, Tingting Meng, Xiaofang Chen, Yunjing Jiang, Dianfeng Zhu, Wenjuan Hu, Jiajie Gong, Shibin Feng, Jinjie Wu & Yu Li. (2016) Deoxynivalenol induces apoptosis in PC12 cells via the mitochondrial pathway. Environmental Toxicology and Pharmacology 43, pages 193-202.
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