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Toxicology Mechanisms and Methods Volume 26, 2016 - Issue 3
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Research Article

Carfilzomib-induced cardiotoxicity mitigated by dexrazoxane through inhibition of hypertrophic gene expression and oxidative stress in rats

Naif O. Al-HarbiDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, KSACorrespondence[email protected]
Pages 189-195 | Received 29 Nov 2015, Accepted 13 Jan 2016, Published online: 21 Feb 2016

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Faisal Imam, Naif O. Al-Harbi, Mohammad Matar Al-Harbi, Mushtaq Ahmad Ansari, Mashal M Almutairi, Musaad Alshammari, Talal Saad Almukhlafi, Mohd Nazam Ansari, Khaldoon Aljerian & Sheikh Fayaz Ahmad. (2016) Apremilast reversed carfilzomib-induced cardiotoxicity through inhibition of oxidative stress, NF-κB and MAPK signaling in rats. Toxicology Mechanisms and Methods 26:9, pages 700-708.
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Articles from other publishers (12)

Toufik Abdul-Rahman, Alden Dunham, Helen Huang, Syed Muhammad Awais Bukhari, Aashna Mehta, Wireko A. Awuah, Deba Ede-Imafidon, Emiliano Cantu-Herrera, Suprateeka Talukder, Amogh Joshi, Deborah W. Sundlof & Rahul Gupta. (2023) Chemotherapy Induced Cardiotoxicity: A State of the Art Review on General Mechanisms, Prevention, Treatment and Recent Advances in Novel Therapeutics. Current Problems in Cardiology 48:4, pages 101591.
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Yi Zheng, Shan Huang, Bingxin Xie, Nan Zhang, Zhiqiang Liu, Gary Tse & Tong Liu. (2023) Cardiovascular Toxicity of Proteasome Inhibitors in Multiple Myeloma Therapy. Current Problems in Cardiology 48:3, pages 101536.
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Perry Wu, Ohad Oren, Morie A. Gertz & Eric H. Yang. (2020) Proteasome Inhibitor-Related Cardiotoxicity: Mechanisms, Diagnosis, and Management. Current Oncology Reports 22:7.
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Faisal Imam, Naif Obaid Al-Harbi, Mohammad Rashid Khan, Wajhul Qamar, Metab Alharbi, Ali A. Alshamrani, Hussain N. Alhamami, Nasser Bader Alsaleh & Khalid Saad Alharbi. (2019) Protective Effect of RIVA Against Sunitinib-Induced Cardiotoxicity by Inhibiting Oxidative Stress-Mediated Inflammation: Probable Role of TGF-β and Smad Signaling. Cardiovascular Toxicology 20:3, pages 281-290.
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El Bitar Sandy, Chanudi Weerasinghe & Terenig Terjanian. (2018) Carfilzomib Induced Tumor Lysis Syndrome and Other Adverse Events. Journal of Pharmacy Practice 33:2, pages 213-216.
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Eugene Herman & Sandy Eldridge. (2019) Spontaneously occurring cardiovascular lesions in commonly used laboratory animals. Cardio-Oncology 5:1.
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Edmund Cheung So, Ping-Yen Liu, Chien-Ching Lee & Sheng-Nan Wu. (2019) High Effectiveness in Actions of Carfilzomib on Delayed-Rectifier K+ Current and on Spontaneous Action Potentials. Frontiers in Pharmacology 10.
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Saras Jyoti & Simran Tandon. (2019) Disruption of mitochondrial membrane potential coupled with alterations in cardiac biomarker expression as early cardiotoxic signatures in human ES cell–derived cardiac cells. Human & Experimental Toxicology 38:9, pages 1111-1124.
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Naif O. Al-Harbi, Faisal Imam, Mohammed M. Al-Harbi, Othman A. Al-Shabanah, Moureq Rashed Alotaibi, Homood M. As Sobeai, Muhammad Afzal, Imran Kazmi & Ammar Cherkess Al Rikabi. (2019) Rutin inhibits carfilzomib-induced oxidative stress and inflammation via the NOS-mediated NF-κB signaling pathway. Inflammopharmacology 27:4, pages 817-827.
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Panagiotis EfentakisGeorgios KremastiotisAimilia VarelaPanagiota-Efstathia NikolaouEleni-Dimitra PapanagnouConstantinos H. DavosMaria TsoumaniGeorgios Agrogiannis, Anastasia Konstantinidou, Efstathios KastritisZoi Kanaki, Efstathios K. Iliodromitis, Apostolos Klinakis, Meletios A. DimopoulosIoannis P. TrougakosIoanna Andreadou & Evangelos Terpos. (2019) Molecular mechanisms of carfilzomib-induced cardiotoxicity in mice and the emerging cardioprotective role of metformin. Blood 133:7, pages 710-723.
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Eleni N. Tsakiri, Evangelos Terpos, Eleni-Dimitra Papanagnou, Efstathios Kastritis, Vincent Brieudes, Maria Halabalaki, Tina Bagratuni, Bogdan I. Florea, Herman S. Overkleeft, Luca Scorrano, Alexios-Leandros Skaltsounis, Meletios A. Dimopoulos & Ioannis P. Trougakos. (2017) Milder degenerative effects of Carfilzomib vs. Bortezomib in the Drosophila model: a link to clinical adverse events. Scientific Reports 7:1.
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Brian B. Hasinoff, Daywin Patel & Xing Wu. (2016) Molecular Mechanisms of the Cardiotoxicity of the Proteasomal-Targeted Drugs Bortezomib and Carfilzomib. Cardiovascular Toxicology 17:3, pages 237-250.
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