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COPD: Journal of Chronic Obstructive Pulmonary Disease Volume 7, 2010 - Issue 2
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CLINICAL REVIEW

Treatment of Chronic Obstructive Pulmonary Disease with Roflumilast, a New Phosphodiesterase 4 Inhibitor

Nicholas J. GrossDepartment of Medicine, St. Francis Hospital & Medical Center, Hartford, Connecticut, USA
,
Mark A. GiembyczDepartment of Physiology & Pharmacology, University of Calgary, Calgary, Canada
&
Stephen I. RennardPulmonary Critical Care, Allergy and Sleep Medicine, University of Nebraska Medical Center, Nebraska, USA
Pages 141-153 | Published online: 16 Apr 2010

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Nicholas Gross. (2013) The COPD Pipeline XX. COPD: Journal of Chronic Obstructive Pulmonary Disease 10:1, pages 104-106.
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William C Groutas, Dengfeng Dou & Kevin R Alliston. (2011) Neutrophil elastase inhibitors. Expert Opinion on Therapeutic Patents 21:3, pages 339-354.
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P. Chervinsky, E.O. Meltzer, W. Busse, K. Ohta, P. Bardin, D. Bredenbröker & E.D. Bateman. (2015) Roflumilast for asthma: Safety findings from a pooled analysis of ten clinical studies. Pulmonary Pharmacology & Therapeutics 35, pages S28-S34.
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H. BinMahfouz, B. Borthakur, D. Yan, T. George, M. A. Giembycz & R. Newton. (2014) Superiority of Combined Phosphodiesterase PDE3/PDE4 Inhibition over PDE4 Inhibition Alone on Glucocorticoid- and Long-Acting  2-Adrenoceptor Agonist-Induced Gene Expression in Human Airway Epithelial Cells. Molecular Pharmacology 87:1, pages 64-76.
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Mark A. Giembycz & Robert Newton. (2014) How Phosphodiesterase 4 Inhibitors Work in Patients with Chronic Obstructive Pulmonary Disease of the Severe, Bronchitic, Frequent Exacerbator Phenotype. Clinics in Chest Medicine 35:1, pages 203-217.
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Timothy E. Albertson, Michael Schivo, Amir A. Zeki, Samuel Louie, Mark E. Sutter, Mark Avdalovic & Andrew L. Chan. (2013) The Pharmacological Approach to the Elderly COPD Patient. Drugs & Aging 30:7, pages 479-502.
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Debra J. ReidNga T. Pham. (2013) Emerging Therapeutic Options for the Management of COPD. Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine 7, pages CCRPM.S8140.
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Nicholas J. Gross. (2012) Novel Antiinflammatory Therapies for COPD. Chest 142:5, pages 1300-1307.
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Ken-Ichiro TanakaKeizo SatoKazutetsu AoshibaArata Azuma & Tohru Mizushima. (2012) Superiority of PC-SOD to other anti-COPD drugs for elastase-induced emphysema and alteration in lung mechanics and respiratory function in mice. American Journal of Physiology-Lung Cellular and Molecular Physiology 302:12, pages L1250-L1261.
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Debra J Reid & Nga T Pham. (2012) Roflumilast: A Novel Treatment for Chronic Obstructive Pulmonary Disease. Annals of Pharmacotherapy 46:4, pages 521-529.
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Stacey L. Tannheimer, Eric A. Sorensen, Aaron C. Haran, Christopher N. Mansfield, Clifford D. Wright & Michael Salmon. (2012) Additive anti-inflammatory effects of beta 2 adrenoceptor agonists or glucocorticosteroid with roflumilast in human peripheral blood mononuclear cells. Pulmonary Pharmacology & Therapeutics 25:2, pages 178-184.
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Teresa A. Schweiger. (2012) Present and Prospective Therapeutic Regimens for COPD. Clinical Medicine Insights: Therapeutics 4, pages CMT.S2106.
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Dennis J. Cada, Terri L. Levien & Danial E. Baker. (2011) Roflumilast. Hospital Pharmacy 46:8, pages 597-606.
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LOUBNA AKHABIR & ANDREW J. SANDFORD. (2011) Genome-wide association studies for discovery of genes involved in asthma. Respirology 16:3, pages 396-406.
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J. Milara, A. Navarro, P. Almudéver, J. Lluch, E. J. Morcillo & J. Cortijo. (2011) Oxidative stress-induced glucocorticoid resistance is prevented by dual PDE3/PDE4 inhibition in human alveolar macrophages. Clinical & Experimental Allergy 41:4, pages 535-546.
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Nancy Elizabeth Larocca, Dolores Moreno, Jenny Valentina Garmendia & Juan Bautista De Sanctis. (2011) NEW PHARMACOLOGICAL TREATMENTS FOR PATIENTS WITH CHRONIC OBSTRUCTIVE PUMONARY DISEASE (COPD). Biomedical Papers 155:1, pages 43-50.
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J.L. Izquierdo Alonso. (2011) Inhibidores de la PDE4: roflumilast. Revista Clínica Española 211, pages 22-30.
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Hashir MajidAmir Sharafkhaneh. (2011) The Pharmacotherapy of Chronic Obstructive Pulmonary Disease in the Elderly: An Update. Clinical Medicine Insights: Therapeutics 3, pages CMT.S3408.
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Lea Breunung & Mike Roberts. (2011) Peripheral muscle dysfunction and chronic obstructive pulmonary disease. British Journal of Hospital Medicine 72:1, pages 17-21.
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Mark A. Giembycz & Robert Newton. 2011. Phosphodiesterases as Drug Targets. Phosphodiesterases as Drug Targets 415 446 .
Jos? Luis Izquierdo Alonso. (2010) Perfil cl?nico del roflumilast. Archivos de Bronconeumolog?a 46, pages 25-32.
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