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Original Research

L-Arginine Pathway in COPD Patients with Acute Exacerbation: A New Potential Biomarker

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Chengyu Yang, Li Yang, Lei Yang, Shuiming Li, Ling Ye, Jinfeng Ye, Chengshui Chen, Yiming Zeng, Mengchan Zhu, Xiaoping Lin, Qing Peng, Yun Wang & Meiling Jin. (2023) Plasma Proteomics Study Between the Frequent Exacerbation and Infrequent Exacerbation Phenotypes of Chronic Obstructive Pulmonary Disease. International Journal of Chronic Obstructive Pulmonary Disease 18, pages 1713-1728.
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Gabor Tajti, Rudolf Gesztelyi, Krisztian Pak, Csaba Papp, Sandor Keki, Magdolna Emma Szilasi, Angela Mikaczo, Andrea Fodor, Maria Szilasi & Judit Zsuga. (2017) Positive correlation of airway resistance and serum asymmetric dimethylarginine level in COPD patients with systemic markers of low-grade inflammation. International Journal of Chronic Obstructive Pulmonary Disease 12, pages 873-884.
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Articles from other publishers (29)

Joaquim Gea, César J. Enríquez-Rodríguez, Bella Agranovich & Sergi Pascual-Guardia. (2023) Update on metabolomic findings in COPD patients. ERJ Open Research 9:5, pages 00180-2023.
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Angelo Zinellu & Arduino A. Mangoni. (2023) Arginine, Transsulfuration, and Folic Acid Pathway Metabolomics in Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis. Cells 12:17, pages 2180.
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Chunhua Ma, Kexi Liao, Jing Wang, Tao Li & Liangming Liu. (2023) l-Arginine, as an essential amino acid, is a potential substitute for treating COPD via regulation of ROS/NLRP3/NF-κB signaling pathway. Cell & Bioscience 13:1.
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Juliane Hannemann, Elin H. Thorarinnsdottir, André F. S. Amaral, Edzard Schwedhelm, Lena Schmidt-Hutten, Heike Stang, Bryndis Benediktsdottir, Ingibjörg Gunnarsdóttir, Thórarinn Gislason & Rainer Böger. (2023) Biomarkers of the L-Arginine/Dimethylarginine/Nitric Oxide Pathway in People with Chronic Airflow Obstruction and Obstructive Sleep Apnoea. Journal of Clinical Medicine 12:16, pages 5230.
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Zsuzsanna Miklós & Ildikó Horváth. (2023) The Role of Oxidative Stress and Antioxidants in Cardiovascular Comorbidities in COPD. Antioxidants 12:6, pages 1196.
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Joaquim Gea, César J. Enríquez-Rodríguez & Sergi Pascual-Guardia. (2023) Metabolomics in COPD. Archivos de Bronconeumología 59:5, pages 311-321.
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Tao Yu, Hanna Wu, Qingxia Huang, Fen Dong, Xuexin Li, Yushi Zhang, Ruirui Duan, Hongtao Niu & Ting Yang. (2023) Outdoor particulate matter exposure affects metabolome in chronic obstructive pulmonary disease: Preliminary study. Frontiers in Public Health 11.
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Helga Kiss, Zoltán Örlős, Áron Gellért, Zsolt Megyesfalvi, Angéla Mikáczó, Anna Sárközi, Attila Vaskó, Zsuzsanna Miklós & Ildikó Horváth. (2023) Exhaled Biomarkers for Point-of-Care Diagnosis: Recent Advances and New Challenges in Breathomics. Micromachines 14:2, pages 391.
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Junling Gao, Tong Lei, Hongyun Wang, Kai Luo, Yuanli Wang, Bingqing Cui, Zhuoran Yu, Xiaoqi Hu, Fang Zhang, Yingjie Chen, Wenjun Ding & Zhongbing Lu. (2022) Dimethylarginine dimethylaminohydrolase 1 protects PM2.5 exposure-induced lung injury in mice by repressing inflammation and oxidative stress. Particle and Fibre Toxicology 19:1.
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Haroon Arshad, Anastasios Siokis, Raimo Franke, Aamna Habib, Juan Carlos López Alfonso, Yuliya Poliakova, Eva Lücke, Katina Michaelis, Mark Brönstrup, Michael Meyer-Hermann, Ursula Bilitewski, Jordi Vila, Laurent Abel, Thomas Illig, Jens Schreiber & Frank Pessler. (2022) Reprogramming of Amino Acid Metabolism Differs between Community-Acquired Pneumonia and Infection-Associated Exacerbation of Chronic Obstructive Pulmonary Disease. Cells 11:15, pages 2283.
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Hongyoon Kim, Sunju Yoo, Jung-Dae Lee, Hyang-Yeon Kim, Suhkmann Kim & Kyu-Bong Kim. (2022) A Metabolomics Approach to Sulforaphane Efficacy in Secondhand Smoking-Induced Pulmonary Damage in Mice. Metabolites 12:6, pages 518.
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Suneeta Godbole, Wassim W. Labaki, Katherine A. Pratte, Andrew Hill, Matthew Moll, Annette T. Hastie, Stephen P. Peters, Andrew Gregory, Victor E. Ortega, Dawn DeMeo, Michael H. Cho, Surya P. Bhatt, J. Michael Wells, Igor Barjaktarevic, Kathleen A. Stringer, Alejandro Comellas, Wanda O’Neal, Katerina Kechris & Russell P. Bowler. (2022) A Metabolomic Severity Score for Airflow Obstruction and Emphysema. Metabolites 12:5, pages 368.
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Qian Huang, Xiaojie Wu, Yiya Gu, Ting Wang, Yuan Zhan, Jinkun Chen, Zhilin Zeng, Yongman Lv, Jianping Zhao & Jungang Xie. (2022) Detection of the Disorders of Glycerophospholipids and Amino Acids Metabolism in Lung Tissue From Male COPD Patients. Frontiers in Molecular Biosciences 9.
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Beata Csiszar, Zsolt Marton, Janos Riba, Peter Csecsei, Lajos Nagy, Kalman Toth, Robert Halmosi, Barbara Sandor, Peter Kenyeres & Tihamer Molnar. (2021) l-arginine, asymmetric and symmetric dimethylarginine for early outcome prediction in unselected cardiac arrest victims: a prospective cohort study. Internal and Emergency Medicine 17:2, pages 525-534.
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Juliane Hannemann & Rainer Böger. (2022) Dysregulation of the Nitric Oxide/Dimethylarginine Pathway in Hypoxic Pulmonary Vasoconstriction—Molecular Mechanisms and Clinical Significance. Frontiers in Medicine 9.
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Marcel Jose Rodríguez-Guzmán, Germán Peces-Barba Romero, Sandra Pérez Rial, Cristina Serrano del Castillo, Miguel Ángel Palomero Rodríguez, Ignacio Mahillo-Fernandez & Felipe Villar-Álvarez. (2021) Elevated levels of arginase activity are related to inflammation in patients with COPD exacerbation. BMC Pulmonary Medicine 21:1.
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Charlie M. Carpenter, Weiming Zhang, Lucas Gillenwater, Cameron Severn, Tusharkanti Ghosh, Russell Bowler, Katerina Kechris & Debashis Ghosh. (2021) PaIRKAT: A pathway integrated regression-based kernel association test with applications to metabolomics and COPD phenotypes. PLOS Computational Biology 17:10, pages e1008986.
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Oleg M. Uryas'yev, Anton Shakhanov & Zharkynai K. Kanatbekova. (2021) Nitric oxide and regulators of its synthesis in chronic obstructive pulmonary disease. I.P. Pavlov Russian Medical Biological Herald 29:3, pages 427-434.
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Erdal İn, Mutlu Kuluöztürk, Teyfik Turgut, Ayşegül Altıntop Geçkil & Nevin İlhan. (2020) Endocan as a potential biomarker of disease severity and exacerbations in COPD. The Clinical Respiratory Journal 15:4, pages 445-453.
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Jian Li, Yufan Lu, Ning Li, Peijun Li, Jianqing Su, Zhengrong Wang, Ting Wang, Zhaoyu Yang, Yahui Yang, Haixia Chen, Lu Xiao, Hongxia Duan, Weibing Wu & Xiaodan Liu. (2020) Muscle metabolomics analysis reveals potential biomarkers of exercise‑dependent improvement of the diaphragm function in chronic obstructive pulmonary disease. International Journal of Molecular Medicine.
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Balázs Csoma, András Bikov, Lajos Nagy, Bence Tóth, Tamás Tábi, Gergő Szűcs, Zsolt István Komlósi, Veronika Müller, György Losonczy & Zsófia Lázár. (2019) Dysregulation of the endothelial nitric oxide pathway is associated with airway inflammation in COPD. Respiratory Research 20:1.
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Linsey E. S. de Groot, T. Anienke van der Veen, Fernando O. Martinez, Jörg Hamann, René Lutter & Barbro N. Melgert. (2019) Oxidative stress and macrophages: driving forces behind exacerbations of asthma and chronic obstructive pulmonary disease?. American Journal of Physiology-Lung Cellular and Molecular Physiology 316:2, pages L369-L384.
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Angelo Zinellu, Alessandro G. Fois, Arduino A. Mangoni, Panagiotis Paliogiannis, Elisabetta Sotgiu, Elisabetta Zinellu, Viviana Marras, Pietro Pirina & Ciriaco Carru. (2018) Systemic concentrations of asymmetric dimethylarginine (ADMA) in chronic obstructive pulmonary disease (COPD): state of the art. Amino Acids 50:9, pages 1169-1176.
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Selda Telo, Gamze Kırkıl, Mutlu Kuluöztürk, Mehmet Balin & Figen Deveci. (2017) Can ADMA play a role in determining pulmonary hypertension related to chronic obstructive pulmonary disease?. The Clinical Respiratory Journal 12:4, pages 1433-1438.
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Kalle Kilk, Argo Aug, Aigar Ottas, Ursel Soomets, Siiri Altraja & Alan Altraja. (2018) Phenotyping of Chronic Obstructive Pulmonary Disease Based on the Integration of Metabolomes and Clinical Characteristics. International Journal of Molecular Sciences 19:3, pages 666.
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Alaadin Vögeli, Manuel Ottiger, Marc A. Meier, Christian Steuer, Luca Bernasconi, Andreas Huber, Mirjam Christ-Crain, Christoph Henzen, Claus Hoess, Robert Thomann, Werner Zimmerli, Beat Mueller & Philipp Schuetz. (2017) Asymmetric Dimethylarginine Predicts Long-Term Outcome in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease. Lung 195:6, pages 717-727.
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Shama Naz, Johan Kolmert, Mingxing Yang, Stacey N. Reinke, Muhammad Anas Kamleh, Stuart Snowden, Tina Heyder, Bettina Levänen, David J. Erle, C. Magnus Sköld, Åsa M. Wheelock & Craig E. Wheelock. (2017) Metabolomics analysis identifies sex-associated metabotypes of oxidative stress and the autotaxin–lysoPA axis in COPD. European Respiratory Journal 49:6, pages 1602322.
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Daniel E. Winnica, Jeremy A. Scott, Hartmut Grasemann & Fernando Holguin. 2017. Nitric Oxide. Nitric Oxide 247 254 .
Renate Jonker, Nicolaas EP Deutz, Marcia L Erbland, Paula J Anderson & Mariëlle PKJ Engelen. (2016) Alterations in whole-body arginine metabolism in chronic obstructive pulmonary disease. The American Journal of Clinical Nutrition 103:6, pages 1458-1464.
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