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Cell Communication & Adhesion Volume 8, 2001 - Issue 4-6
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Original Article

Bisphosphonate-Induced, Hemichannel-Mediated, Anti-Apoptosis Through the Src/ERK Pathway: A Gap Junction-Independent Action of Connexin43

L. I. Plotkin Division of Endocrinology and Metabolism, the Center for Osteoporosis and Metabolic Bone Diseases, and the Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, AR, USA
&
T. Bellido Division of Endocrinology and Metabolism, the Center for Osteoporosis and Metabolic Bone Diseases, and the Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, AR, USACorrespondence[email protected]
Pages 377-382 | Received 01 Sep 2001, Accepted 15 Sep 2001, Published online: 11 Jul 2009

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Pooyan Sadr-Eshkevari, Sajjad Ashnagar, Ashkan Rashad, Marisa Dietz, Jochen Jackowski, Amr Abdulazim & Nora Prochnow. (2014) Bisphosphonates and Connexin 43: A Critical Review of Evidence. Cell Communication & Adhesion 21:5, pages 241-247.
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Su Jin Kim, Su Yung Kim, Chae Hwa Kwon & Yong Keun Kim. (2007) Differential effect of FGF and PDGF on cell proliferation and migration in osteoblastic cells. Growth Factors 25:2, pages 77-86.
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Senbo An, Shengyuan Zheng, Zijun Cai, Siyu Chen, Chen Wang, Yusheng Li & Zhenhan Deng. (2022) Connexin43 in Musculoskeletal System: New Targets for Development and Disease Progression. Aging and disease 13:6, pages 1715.
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Geert Bultynck. (2016) The anti-metastatic micro-environment of the bone: Importance of osteocyte Cx43 hemichannels. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1866:1, pages 121-127.
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Lilian I. Plotkin, Toni L. Speacht & Henry J. Donahue. (2015) Cx43 and Mechanotransduction in Bone. Current Osteoporosis Reports 13:2, pages 67-72.
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Tanya Zappitelli & Jane E. Aubin. (2014) The “Connexin” Between Bone Cells and Skeletal Functions. Journal of Cellular Biochemistry 115:10, pages 1646-1658.
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Guotian Yin, Xiuli Yang, Bo Li, Meng Yang & Mingfen Ren. (2014) Connexin43 siRNA promotes HUVEC proliferation and inhibits apoptosis induced by ox-LDL: an involvement of ERK signaling pathway. Molecular and Cellular Biochemistry 394:1-2, pages 101-107.
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Lianghua Ding, Shuanghua He & Xiaoliang Sun. (2014) HSP70 desensitizes osteosarcoma cells to baicalein and protects cells from undergoing apoptosis. Apoptosis 19:8, pages 1269-1280.
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Teresita Bellido. (2013) Osteocyte-Driven Bone Remodeling. Calcified Tissue International 94:1, pages 25-34.
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Alayna E. Loiselle, Jean X. Jiang & Henry J. Donahue. (2013) Gap junction and hemichannel functions in osteocytes. Bone 54:2, pages 205-212.
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P Kameritsch, N Khandoga, U Pohl & K Pogoda. (2013) Gap junctional communication promotes apoptosis in a connexin-type-dependent manner. Cell Death & Disease 4:4, pages e584-e584.
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Hyung Min Jeong, Yun-Hey Jin, You-Hee Choi, Jin Ook Chung, Dong Hyeok Cho, Min Young Chung, Roberto Civitelli, Dong Jin Chung & Kwang Youl Lee. (2013) Risedronate increases osteoblastic differentiation and function through connexin43. Biochemical and Biophysical Research Communications 432:1, pages 152-156.
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Susana Morelli, Paola Scodelaro Bilbao, Sebastian Katz, Virginia Lezcano, Emilio Roldán, Ricardo Boland & Graciela Santillan. (2011) Protein phosphatases: Possible bisphosphonate binding sites mediating stimulation of osteoblast proliferation. Archives of Biochemistry and Biophysics 507:2, pages 248-253.
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Anna Enjuanes, Silvia Ruiz-Gaspà, Pilar Peris, Dolores Ozalla, Luisa Álvarez, Andrés Combalia, M. Jesús Martínez de Osaba, Ana Monegal, Albert Pares & Nuria Guañabens. (2010) The effect of the alendronate on OPG/RANKL system in differentiated primary human osteoblasts. Endocrine 37:2, pages 322-328.
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Roberto Civitelli. (2008) Connexin43 Modulation of Osteoblast/Osteocyte Apoptosis: A Potential Therapeutic Target?. Journal of Bone and Mineral Research 23:11, pages 1709-1711.
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