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Review Article

Desmosomal Cadherins and Signaling: Lessons from Autoimmune Disease

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Pages 77-84 | Received 26 Nov 2013, Accepted 16 Dec 2013, Published online: 24 Jan 2014

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Read on this site (4)

Si Li, Qin Zhang, Peng Wang, Jun Li, Jing Ni, Jun Wu, Yan Liang, Rui-Xue Leng, Hai-Feng Pan & Dong-Qing Ye. (2018) Association between HLA-DQB1 polymorphisms and pemphigus vulgaris: A meta-analysis. Immunological Investigations 47:1, pages 101-112.
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Nicola Cirillo. (2016) Desmosome assembly, homeostasis, and desmosomal disease. Cell Health and Cytoskeleton 8, pages 9-23.
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Otmar Huber & Iver Petersen. (2015) 150th Anniversary Series: Desmosomes and the Hallmarks of Cancer. Cell Communication & Adhesion 22:1, pages 15-28.
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Articles from other publishers (32)

Thomas Schmitt, Christoph Hudemann, Sina Moztarzadeh, Michael Hertl, Ritva Tikkanen & Jens Waschke. (2023) Dsg3 epitope-specific signalling in pemphigus. Frontiers in Immunology 14.
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Christoph Hudemann, Yvonne Exner, Robert Pollmann, Karina Schneider, Anna Zakrzewicz, Simon Feldhoff, Thomas Schmidt, Volker Spindler, David Rafei-Shamsabadi, Frauke Völlner, Jens Waschke, Ritva Tikkanen, Michael Hertl & Rüdiger Eming. (2023) IgG against the Membrane-Proximal Portion of the Desmoglein 3 Ectodomain Induces Loss of Keratinocyte Adhesion, a Hallmark in Pemphigus Vulgaris. Journal of Investigative Dermatology 143:2, pages 254-263.e3.
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Sunil Yeruva & Jens Waschke. (2022) Structure and regulation of desmosomes in intercalated discs: Lessons from epithelia. Journal of Anatomy 242:1, pages 81-90.
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Ciqing Yang, Yaping Shi, Xiaoying Li, Lihong Guan, Han Li & Juntang Lin. (2022) Cadherins and the pathogenesis of epilepsy. Cell Biochemistry and Function 40:4, pages 336-348.
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Anna Zakrzewicz, Celina Würth, Benedikt Beckert, Simon Feldhoff, Katrien Vanderheyden, Stian Foss, Jan Terje Andersen, Hans de Haard, Peter Verheesen, Vladimir Bobkov & Ritva Tikkanen. (2022) Stabilization of Keratinocyte Monolayer Integrity in the Presence of Anti-Desmoglein-3 Antibodies through FcRn Blockade with Efgartigimod: Novel Treatment Paradigm for Pemphigus?. Cells 11:6, pages 942.
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Christoph T. Ellebrecht, Damian Maseda & Aimee S. Payne. (2022) Pemphigus and Pemphigoid: From Disease Mechanisms to Druggable Pathways. Journal of Investigative Dermatology 142:3, pages 907-914.
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Bavleen Kaur, Jenna Kerbrat, Jia Kho, Manreet Kaler, Stefanos Kanatsios & Nicola Cirillo. (2021) Mechanism‐based therapeutic targets of pemphigus vulgaris: A scoping review of pathogenic molecular pathways. Experimental Dermatology 31:2, pages 154-171.
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Thomas Schmitt & Jens Waschke. (2021) Autoantibody-Specific Signalling in Pemphigus. Frontiers in Medicine 8.
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Marie‐Therès Wanuske, Dominique Brantschen, Camilla Schinner, Chiara Stüdle, Elias Walter, Matthias Hiermaier, Franziska Vielmuth, Jens Waschke & Volker Spindler. (2021) Clustering of desmosomal cadherins by desmoplakin is essential for cell‐cell adhesion. Acta Physiologica 231:4.
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Jürgen Behrens. 2021. Encyclopedia of Molecular Pharmacology. Encyclopedia of Molecular Pharmacology 393 398 .
Camilla Schinner, Silvana Olivares-Florez, Angela Schlipp, Sebastian Trenz, Manouk Feinendegen, Heinrich Flaswinkel, Ellen Kempf, Desalegn Tadesse Egu, Sunil Yeruva & Jens Waschke. (2020) The inotropic agent digitoxin strengthens desmosomal adhesion in cardiac myocytes in an ERK1/2-dependent manner. Basic Research in Cardiology 115:4.
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Lisa Müller, Katrin Rietscher, René Keil, Marvin Neuholz & Mechthild Hatzfeld. (2020) Plakophilin 3 phosphorylation by ribosomal S6 kinase supports desmosome assembly. Journal of Cell Science.
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Jürgen Behrens. 2020. Encyclopedia of Molecular Pharmacology. Encyclopedia of Molecular Pharmacology 1 5 .
Jens Waschke. (2019) Desmogleins as signaling hubs regulating cell cohesion and tissue/organ function in skin and heart — EFEM lecture 2018. Annals of Anatomy - Anatomischer Anzeiger 226, pages 96-100.
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Xiaowen Lu & Mitchell A. Watsky. (2019) Influence of Vitamin D on Corneal Epithelial Cell Desmosomes and Hemidesmosomes. Investigative Opthalmology & Visual Science 60:13, pages 4074.
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Michael Fuchs, Marco Foresti, Mariya Y. Radeva, Daniela Kugelmann, Rene Keil, Mechthild Hatzfeld, Volker Spindler, Jens Waschke & Franziska Vielmuth. (2019) Plakophilin 1 but not plakophilin 3 regulates desmoglein clustering. Cellular and Molecular Life Sciences 76:17, pages 3465-3476.
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Natalia Colás-Algora & Jaime Millán. (2018) How many cadherins do human endothelial cells express?. Cellular and Molecular Life Sciences 76:7, pages 1299-1317.
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Jun-Ichi Sasaki, Chihiro Katata, Gabriela L Abe, Takuya Matsumoto & Satoshi Imazato. (2019) Fabricating large-scale three-dimensional constructs with living cells by processing with syringe needles. Journal of Biomedical Materials Research Part A 107:4, pages 904-909.
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Hanna Ungewiß, Vera Rötzer, Michael Meir, Christina Fey, Markus Diefenbacher, Nicolas Schlegel & Jens Waschke. (2018) Dsg2 via Src-mediated transactivation shapes EGFR signaling towards cell adhesion. Cellular and Molecular Life Sciences 75:22, pages 4251-4268.
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Mark Yulis, Dennis H. M. Kusters & Asma Nusrat. (2018) Cadherins: cellular adhesive molecules serving as signalling mediators. The Journal of Physiology 596:17, pages 3883-3898.
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Franziska Vielmuth, Elias Walter, Michael Fuchs, Mariya Y. Radeva, Fanny Buechau, Thomas M. Magin, Volker Spindler & Jens Waschke. (2018) Keratins Regulate p38MAPK-Dependent Desmoglein Binding Properties in Pemphigus. Frontiers in Immunology 9.
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Volker Spindler, Rüdiger Eming, Enno Schmidt, Masayuki Amagai, Sergei Grando, Marcel F. Jonkman, Andrew P. Kowalczyk, Eliane J. Müller, Aimee S. Payne, Carlo Pincelli, Animesh A. Sinha, Eli Sprecher, Detlef Zillikens, Michael Hertl & Jens Waschke. (2018) Mechanisms Causing Loss of Keratinocyte Cohesion in Pemphigus. Journal of Investigative Dermatology 138:1, pages 32-37.
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D.T. Egu, E. Walter, V. Spindler & J. Waschke. (2017) Inhibition of p38MAPK signalling prevents epidermal blistering and alterations of desmosome structure induced by pemphigus autoantibodies in human epidermis. British Journal of Dermatology 177:6, pages 1612-1618.
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Hanna Ungewiß, Franziska Vielmuth, Shintaro T. Suzuki, Andreas Maiser, Hartmann Harz, Heinrich Leonhardt, Daniela Kugelmann, Nicolas Schlegel & Jens Waschke. (2017) Desmoglein 2 regulates the intestinal epithelial barrier via p38 mitogen-activated protein kinase. Scientific Reports 7:1.
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Chrysovalantou Mihailidou, Nikos Katsoulas, Eleni Panagiotou, Elena Farmaki, Alexandra Sklavounou, Hippokratis Kiaris & Ioulia Chatzistamou. (2016) Endoplasmic reticulum stress is associated with the pathogenesis of pemphigus vulgaris. Experimental Dermatology 25:9, pages 731-733.
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Vera Rötzer, Eva Hartlieb, Julia Winkler, Elias Walter, Angela Schlipp, Miklós Sardy, Volker Spindler & Jens Waschke. (2016) Desmoglein 3-Dependent Signaling Regulates Keratinocyte Migration and Wound Healing. Journal of Investigative Dermatology 136:1, pages 301-310.
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Vera Rötzer, Eva Hartlieb, Franziska Vielmuth, Martin Gliem, Volker Spindler & Jens Waschke. (2015) E-cadherin and Src associate with extradesmosomal Dsg3 and modulate desmosome assembly and adhesion. Cellular and Molecular Life Sciences 72:24, pages 4885-4897.
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Volker Spindler, Michael Meir, Balázs Vigh, Sven Flemming, Katharina Hütz, Christoph-Thomas Germer, Jens Waschke & Nicolas Schlegel. (2015) Loss of Desmoglein 2 Contributes to the Pathogenesis of Crohnʼs Disease. Inflammatory Bowel Diseases, pages 1.
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Madoka Kato, Akira Shimizu, Yoko Yokoyama, Kyoichi Kaira, Yutaka Shimomura, Akemi Ishida-Yamamoto, Kiyoko Kamei, Fuminori Tokunaga & Osamu Ishikawa. (2015) An Autosomal Recessive Mutation of DSG4 Causes Monilethrix through the ER Stress Response. Journal of Investigative Dermatology 135:5, pages 1253-1260.
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F Pettini, A Ballini, S Capodiferro, S Cantore, N Cirulli, A Garofalo, MF Coscia, D De Vito & C Foti. (2015) Management of oral pemphigus vulgaris: A case report and a clinical update. European Journal of Inflammation 13:1, pages 53-57.
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Franziska Vielmuth, Eva Hartlieb, Daniela Kugelmann, Jens Waschke & Volker Spindler. (2015) Atomic force microscopy identifies regions of distinct desmoglein 3 adhesive properties on living keratinocytes. Nanomedicine: Nanotechnology, Biology and Medicine 11:3, pages 511-520.
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Vera Rötzer, Andreas Breit, Jens Waschke & Volker Spindler. (2014) Adducin Is Required for Desmosomal Cohesion in Keratinocytes. Journal of Biological Chemistry 289:21, pages 14925-14940.
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