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Journal of Immunotoxicology Volume 10, 2013 - Issue 1
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Paper from the 20th Summerschool in Immunotoxicology, Beaune, France, Sept. 26–28, 2011

The Göttingen minipig® as an alternative non-rodent species for immunogenicity testing: A demonstrator study using the IL-1 receptor antagonist anakinra

Geertje J. D. van MierloDepartment of Toxicology and Risk Assessment, TNO Triskelion BV, Zeist, The NetherlandsCorrespondence[email protected]
,
Nicole H. P. CnubbenDepartment of Toxicology and Risk Assessment, TNO Triskelion BV, Zeist, The Netherlands
,
C. Frieke KuperTNO Earth, Environmental and Life Sciences, Zeist, The Netherlands
,
Jasja WolthoornDepartment of Analytical Research, TNO Triskelion BV, Zeist, The Netherlands
,
Angelique P. van Meeteren-KreikampDepartment of Analytical Research, TNO Triskelion BV, Zeist, The Netherlands
,
Machiel M. NagtegaalDepartment of Analytical Research, TNO Triskelion BV, Zeist, The Netherlands
,
Robert Doornbos
,
Niels-Christian GanderupEllegaard Göttingen Minipigs, Dalmose, Denmark
&
André H. PenninksDepartment of Toxicology and Risk Assessment, TNO Triskelion BV, Zeist, The Netherlands
 show all
Pages 96-105 | Received 02 Jul 2012, Accepted 25 Sep 2012, Published online: 07 Nov 2012

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Geertje J. D. van Mierlo, Nicole H. P. Cnubben, Diana Wouters, Gerrit Jan Wolbink, Margreet H. L. Hart, Theo Rispens, Niels-Christian Ganderup, C. Frieke Kuper, Lucien Aarden & André H. Penninks. (2014) The minipig as an alternative non-rodent model for immunogenicity testing using the TNFα blockers adalimumab and infliximab. Journal of Immunotoxicology 11:1, pages 62-71.
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Articles from other publishers (13)

Tomasz Grabowski, Rafał Derlacz & Artur Burmańczuk. (2022) Göttingen pigs as a potential model for natalizumab pharmacokinetics, pharmacodynamics, and immunogenicity evaluation. Biomedicine & Pharmacotherapy 156, pages 113926.
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Tomasz Grabowski, Artur Burmańczuk, Rafał Derlacz, Tadeusz Stefaniak, Anna Rząsa & Jacek Borkowski. (2021) Ustekinumab pharmacokinetics after subcutaneous administration in swine model. Journal of Veterinary Science 22:5.
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Yong-Wook Son, Ha-Ni Choi, Jeong-Hwan Che, Byeong-Cheol Kang & Jun-Won Yun. (2020) Advances in selecting appropriate non-rodent species for regulatory toxicology research: Policy, ethical, and experimental considerations. Regulatory Toxicology and Pharmacology 116, pages 104757.
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Jacques Descotes, Linda Allais, Philippe Ancian, Henrik Duelund Pedersen, Claire Friry-Santini, Antonio Iglesias, Tina Rubic-Schneider, Hollie Skaggs & Peter Vestbjerg. (2018) Nonclinical evaluation of immunological safety in Göttingen Minipigs: The CONFIRM initiative. Regulatory Toxicology and Pharmacology 94, pages 271-275.
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Wim Jiskoot, Grzegorz Kijanka, Theodore W. Randolph, John F. Carpenter, Atanas V. Koulov, Hanns-Christian Mahler, Marisa K. Joubert, Vibha Jawa & Linda O. Narhi. (2016) Mouse Models for Assessing Protein Immunogenicity: Lessons and Challenges. Journal of Pharmaceutical Sciences 105:5, pages 1567-1575.
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Joshua A. Jackman, Tamás Mészáros, Tamás Fülöp, Rudolf Urbanics, Janos Szebeni & Nam-Joon Cho. (2016) Comparison of complement activation-related pseudoallergy in miniature and domestic pigs: foundation of a validatable immune toxicity model. Nanomedicine: Nanotechnology, Biology and Medicine 12:4, pages 933-943.
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Tina Rubic-Schneider, Brigitte Christen, Dominique Brees & Michael Kammüller. (2016) Minipigs in Translational Immunosafety Sciences. Toxicologic Pathology 44:3, pages 315-324.
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Karina Gutierrez, Naomi Dicks, Werner G. Glanzner, Luis B. Agellon & Vilceu Bordignon. (2015) Efficacy of the porcine species in biomedical research. Frontiers in Genetics 6.
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Mihaela Peric, Ivo Dumic-Cule, Danka Grcevic, Mario Matijasic, Donatella Verbanac, Ruth Paul, Lovorka Grgurevic, Vladimir Trkulja, Cedo M. Bagi & Slobodan Vukicevic. (2015) The rational use of animal models in the evaluation of novel bone regenerative therapies. Bone 70, pages 73-86.
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Georg Schmitt, Paul Barrow & Markus Stephan-Gueldner. 2015. The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment. The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment 337 355 .
John Webster. (2014) Ethical and Animal Welfare Considerations in Relation to Species Selection for Animal Experimentation. Animals 4:4, pages 729-741.
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Takuya Suzuki, Masako Ichihara, Kenji Hyodo, Eiichi Yamamoto, Tatsuhiro Ishida, Hiroshi Kiwada, Hiroshi Kikuchi & Hiroshi Ishihara. (2014) Influence of dose and animal species on accelerated blood clearance of PEGylated liposomal doxorubicin. International Journal of Pharmaceutics 476:1-2, pages 205-212.
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Niels-Christian Ganderup. 2014. Biomarkers in Toxicology. Biomarkers in Toxicology 71 91 .

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