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Journal of Immunotoxicology Volume 13, 2016 - Issue 3
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Research Article

St. John’s wort and its component hyperforin alleviate experimental autoimmune encephalomyelitis through expansion of regulatory T-cells

Reza NosratabadiSchool of Medicine, Immunology Research Center, BuAli Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran; ;Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran;
,
Maryam RastinSchool of Medicine, Immunology Research Center, BuAli Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran;
,
Mojtaba SankianSchool of Medicine, Immunology Research Center, BuAli Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran;
,
Dariush HaghmoradSchool of Medicine, Immunology Research Center, BuAli Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran;
,
Nafiseh TabasiSchool of Medicine, Immunology Research Center, BuAli Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran;
,
Shahrzad ZamaniSchool of Medicine, Immunology Research Center, BuAli Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran;
,
Azita AghaeePharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
,
Zohre SalehipourSchool of Medicine, Immunology Research Center, BuAli Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran;
&
Mahmoud MahmoudiSchool of Medicine, Immunology Research Center, BuAli Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Correspondence[email protected]
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Pages 364-374 | Received 28 May 2015, Accepted 24 Sep 2015, Published online: 03 Dec 2015

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S Selek, M Esrefoglu, I Meral, H Bulut, HG Caglar, G Sonuc, C Yildiz, ES Teloglu, N Dogan, B Yuce, E Tiftik & N Bayindir. (2019) Effects of Oenothera biennis L. and Hypericum perforatum L. extracts on some central nervous system myelin proteins, brain histopathology and oxidative stress in mice with experimental autoimmune encephalomyelitis. Biotechnic & Histochemistry 94:2, pages 75-83.
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Dariush Haghmorad, Zohreh Salehipour, Reza Nosratabadi, Maryam Rastin, Parviz Kokhaei, Mohammad Bagher Mahmoudi, Abbas Ali Amini & Mahmoud Mahmoudi. (2016) Medium-dose estrogen ameliorates experimental autoimmune encephalomyelitis in ovariectomized mice. Journal of Immunotoxicology 13:6, pages 885-896.
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Xin-Xin Li, Yu Yan, Jia Zhang, Kang Ding, Cong-Yuan Xia, Xue-Ge Pan, Yan-Jing Shi, Jie-Kun Xu, Jun He & Wei-Ku Zhang. (2023) Hyperforin: A natural lead compound with multiple pharmacological activities. Phytochemistry 206, pages 113526.
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Gonçalo Infante Caldeira, Luís Pleno Gouveia, Rita Serrano & Olga Duarte Silva. (2022) Hypericum Genus as a Natural Source for Biologically Active Compounds. Plants 11:19, pages 2509.
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Jalili Shahla, Haghmorad Dariush, Sedighi Moghadam Bijan, Eslami Majid, Amiri Zahra & Yousefi Bahman. (2021) Comparative immunomodulatory effects of jelly royal and 10-H2DA on experimental autoimmune encephalomyelitis. Gene Reports 24, pages 101217.
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A. L. Budantsev, V. A. Prikhodko, I. V. Varganova & S. V. Okovityi. (2021) BIOLOGICAL ACTIVITY OF HYPERICUM PERFORATUM L. (HYPERICACEAE): A REVIEW. Pharmacy & Pharmacology 9:1, pages 17-31.
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Zahra Navi, Abdolmajid Fata, Mozhdeh Jafari Rad, Elham Mogaddas, Mahmoud Mahmoudi, Maryam Rastin, Mojtaba Mousavi Bazaz, Fahimeh Lavi Arab, Sajad Sahab Negah & Amir Reza Heidari. (2020) Dicrocoelium ova can block the induction phase of experimental autoimmune encephalomyelitis . Parasite Immunology 42:12.
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Amir Reza Heidari, Samaneh Boroumand-Noughabi, Reza Nosratabadi, Fahimeh Lavi Arab, Nafiseh Tabasi, Maryam Rastin & Mahmoud Mahmoudi. (2019) Acylated and deacylated quillaja saponin-21 adjuvants have opposite roles when utilized for immunization of C57BL/6 mice model with MOG35-55 peptide. Multiple Sclerosis and Related Disorders 29, pages 68-82.
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Zohre Salehipour, Dariush Haghmorad, Mojtaba Sankian, Maryam Rastin, Reza Nosratabadi, Mohammad Mehdi Soltan Dallal, Nafiseh Tabasi, Mahdieh Khazaee, Leila Roozbeh Nasiraii & Mahmoud Mahmoudi. (2017) Bifidobacterium animalis in combination with human origin of Lactobacillus plantarum ameliorate neuroinflammation in experimental model of multiple sclerosis by altering CD4+ T cell subset balance. Biomedicine & Pharmacotherapy 95, pages 1535-1548.
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Michela Novelli, Marta Menegazzi, Pascale Beffy, Svetlana Porozov, Alex Gregorelli, Daniela Giacopelli, Vincenzo De Tata & Pellegrino Masiello. (2016) St. John’s wort extract and hyperforin inhibit multiple phosphorylation steps of cytokine signaling and prevent inflammatory and apoptotic gene induction in pancreatic β cells. The International Journal of Biochemistry & Cell Biology 81, pages 92-104.
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