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Original Article

Intestinal Neuronal Density in Childhood: A Baseline for the Objective Assessment of Hypo- and Hyperganglionosis

Pages 225-237 | Received 21 Sep 1991, Accepted 09 Sep 1992, Published online: 09 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Iva Gasparovic, Drazen Kovac, Mladen Persic, Irena Slavic, Harry Nikolic & Nives Jonjic. (2011) Ganglia/Nerve Fibers Ratio Correlates with the Need for Surgery in Patients Diagnosed with Hirschsprung's Disease Allied Disorder (HAD). Fetal and Pediatric Pathology 30:6, pages 405-413.
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Raj P. Kapur. (1999) Hirschsprung Disease and Other Enteric Dysganglionoses. Critical Reviews in Clinical Laboratory Sciences 36:3, pages 225-273.
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Matthias J. Szabolcs, James Visser, Michael L. Shelanski, Kathleen O'Toole & John N. Schullinger. (1996) PERIPHERIN: A Novel Marker for the Immunohistochemical Study of Malformations of the Enteric Nervous System. Pediatric Pathology & Laboratory Medicine 16:1, pages 51-70.
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Articles from other publishers (46)

Raj P. Kapur, Andrew M. Bellizzi, Steffan Bond, Haiying Chen, Jeong S. Han, Robin D. LeGallo, Craig Midgen, Alysa A. Poulin, Naseem Uddin, Mikako Warren, José E. Velázquez Vega & Craig W. Zuppan. (2021) Congenital Myenteric Hypoganglionosis. American Journal of Surgical Pathology 45:8, pages 1047-1060.
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Hinglaj Saha, Aniket Halder, Uttara Chatterjee & Koushik Saha. (2019) Clinicopathological study of intestinal smooth muscles, interstitial cells of Cajal, and enteric neurons in neonatal jejuno-ileal atresia with special reference to muscle morphometry. Journal of Pediatric Surgery 54:11, pages 2291-2299.
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Raj P. KapurMiguel Reyes-Mugica. (2018) Intestinal Neuronal Dysplasia Type B: An Updated Review of a Problematic Diagnosis. Archives of Pathology & Laboratory Medicine 143:2, pages 235-243.
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Florian Friedmacher & Prem Puri. 2019. Hirschsprung's Disease and Allied Disorders. Hirschsprung's Disease and Allied Disorders 305 322 .
Mitsuru Muto, Hiroshi Matsufuji, Tomoaki Taguchi, Takeshi Tomomasa, Masaki Nio, Hiroshi Tamai, Masanori Tamura, Haruhiko Sago, Akira Toki, Shunsuke Nosaka, Tatsuo Kuroda, Masahiro Yoshida, Atsushi Nakajima, Hiroyuki Kobayashi, Hideki Sou, Kouji Masumoto, Yoshio Watanabe, Yutaka Kanamori, Yoshinori Hamada, Atsuyuki Yamataka, Naoki Shimojima, Akio Kubota, Kosuke Ushijima, Ken Haruma, Shin Fukudo, Yuko Araki, Takahiro Kudo, Satoshi Obata, Wataru Sumita, Toshihiko Watanabe, Suguru Fukahori, Yoshimitsu Fujii, Yoshiyuki Yamada, Keisuke Jimbo, Fujimi Kawai, Tomoya Fukuoka, Shinsuke Onuma, Toshio Morizane, Satoshi Ieiri, Genshiro Esumi, Takahiro Jimbo & Tomoko Yamasaki. (2018) Japanese clinical practice guidelines for allied disorders of Hirschsprung's disease, 2017. Pediatrics International 60:5, pages 400-410.
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Bodil Ohlsson, Rita J. Gustafsson, Ervin Toth, Bèla Veress & Henrik Thorlacius. (2018) Endoscopic versus Laparoscopic Full-Thickness Biopsy in the Pathological Evaluation of the Enteric Nervous System. Case Reports in Gastroenterology 12:1, pages 32-40.
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Michael Ashworth. 2018. Rickham's Neonatal Surgery. Rickham's Neonatal Surgery 105 167 .
S. W. Moore. (2016) Advances in understanding functional variations in the Hirschsprung disease spectrum (variant Hirschsprung disease). Pediatric Surgery International 33:3, pages 285-298.
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Keiichi Fujiya, Ja-Mun Chong, Masayuki Ando, Hidetaka Akita, Akira Fukuda, Takeshi Nagahama & Kuniyoshi Arai. (2015) Sigmoid volvulus is associated with a decrease in enteric plexuses and ganglion cells: a case–control study. International Journal of Colorectal Disease 30:5, pages 673-678.
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Raj P. Kapur. 2014. Pathology of Pediatric Gastrointestinal and Liver Disease. Pathology of Pediatric Gastrointestinal and Liver Disease 249 316 .
M.G. Schäppi, A. Staiano, P.J. Milla, V.V. Smith, J.A. Dias, R. Heuschkel, S. Husby, M.L. Mearin, A. Papadopoulou, F.M. Ruemmele, Yvan Vandenplas & S. Koletzko. (2013) A Practical Guide for the Diagnosis of Primary Enteric Nervous System Disorders. Journal of Pediatric Gastroenterology & Nutrition 57:5, pages 677-686.
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Florian Friedmacher & Prem Puri. (2013) Classification and diagnostic criteria of variants of Hirschsprung’s disease. Pediatric Surgery International 29:9, pages 855-872.
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Elias N. Alexandrakis & Josef Rüschoff. 2013. Pathologie. Pathologie 491 510 .
Virpi Vanamo Smith. 2013. Pediatric Neurogastroenterology. Pediatric Neurogastroenterology 187 202 .
C. H. Knowles, B. Veress, R. P. Kapur, T. Wedel, G. Farrugia, J.-M. Vanderwinden, K. Geboes, V. V. Smith, J. E. Martin, G. Lindberg, P. J. Milla & R. De Giorgio. (2011) Quantitation of cellular components of the enteric nervous system in the normal human gastrointestinal tract - report on behalf of the Gastro 2009 International Working Group. Neurogastroenterology & Motility 23:2, pages 115-124.
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Maya Swaminathan & Raj P. Kapur. (2010) Counting myenteric ganglion cells in histologic sections: an empirical approach. Human Pathology 41:8, pages 1097-1108.
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Hyung Kyung KimHarin CheongHanna KangJi Yoon BaeDong Eun SongMin Sun ChoSun Hee SungWoon Sup HanHeasoo Koo. (2010) Histopathological Evaluation of Pediatric Intestinal Pseudo-Obstruction: Quantitative Morphometric Analysis of Pathological Changes in the Enteric Nervous System. The Korean Journal of Pathology 44:2, pages 162.
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Neil J Sebire, Michael Ashworth, Marian Malone, Thomas S Jacques & Beverly B Rogers. 2010. Diagnostic Pediatric Surgical Pathology. Diagnostic Pediatric Surgical Pathology 529 609 .
Thambipillai Sri Paran, Udo Rolle & Prem Puri. (2009) Age-related changes in the myenteric plexus of the porcine bowel. Journal of Pediatric Surgery 44:9, pages 1771-1777.
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Charles H. Knowles, Roberto De Giorgio, Raj P. Kapur, Elisabeth Bruder, Gianrico Farrugia, Karel Geboes, Michael D. Gershon, John Hutson, Greger Lindberg, Joanne E. Martin, William A. Meier-Ruge, Peter J. Milla, Virpi V. Smith, Jean Marie Vandervinden, Béla Veress & Thilo Wedel. (2009) Gastrointestinal neuromuscular pathology: guidelines for histological techniques and reporting on behalf of the Gastro 2009 International Working Group. Acta Neuropathologica 118:2, pages 271-301.
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Marlene M. Hao & Heather M. Young. (2009) Development of enteric neuron diversity. Journal of Cellular and Molecular Medicine 13:7, pages 1193-1210.
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Chiara Ippolito, Cristina Segnani, Roberto De Giorgio, Corrado Blandizzi, Letizia Mattii, Maura Castagna, Stefania Moscato, Amelio Dolfi & Nunzia Bernardini. (2009) Quantitative evaluation of myenteric ganglion cells in normal human left colon: implications for histopathological analysis. Cell and Tissue Research 336:2, pages 191-201.
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Hye Jin Kim, Ah Young Kim, Choong Wook Lee, Chang Sik Yu, Jung-Sun Kim, Pyo Nyun Kim, Moon-Gyu Lee & Hyun Kwon Ha. (2008) Hirschsprung Disease and Hypoganglionosis in Adults: Radiologic Findings and Differentiation. Radiology 247:2, pages 428-434.
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A.M. Holschneider, P. Puri, L.H. Homrighausen & W. Meier-Ruge. 2008. Hirschsprung's Disease and Allied Disorders. Hirschsprung's Disease and Allied Disorders 229 251 .
Virpi V Smith. (2007) Pathology of Paediatric Gastrointestinal Neuromuscular Disease. Journal of Pediatric Gastroenterology & Nutrition 45:Suppl 2, pages S93-S96.
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Tomoaki Taguchi, Kouji Masumoto, Satoshi Ieiri, Takanori Nakatsuji & Junko Akiyoshi. (2006) New classification of hypoganglionosis: congenital and acquired hypoganglionosis. Journal of Pediatric Surgery 41:12, pages 2046-2051.
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Thambipillai Sri Paran, Udo Rolle & Prem Puri. (2006) Enteric nervous system and developmental abnormalities in childhood. Pediatric Surgery International 22:12, pages 945-959.
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Sandra Montedonico, Thambipillai Sri Paran, Martina Pirker, Udo Rolle & Prem Puri. (2006) Developmental changes in submucosal nitrergic neurons in the porcine distal colon. Journal of Pediatric Surgery 41:5, pages 1029-1035.
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Prem Puri. 2006. Pediatric Surgery. Pediatric Surgery 1560 1565 .
Prem Puri & Udo Rolle. (2004) Variant Hirschsprung’s disease. Seminars in Pediatric Surgery 13:4, pages 293-299.
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Raj P. Kapur. 2004. Pathology of Pediatric Gastrointestinal and Liver Disease. Pathology of Pediatric Gastrointestinal and Liver Disease 128 156 .
Virpi V Smith & Peter J Milla. 2004. Pathophysiology of the Enteric Nervous System. Pathophysiology of the Enteric Nervous System 46 60 .
Prem Puri. (2003) Intestinal neuronal dysplasia. Seminars in Pediatric Surgery 12:4, pages 259-264.
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Melissa A Parisi, Audrey E Baldessari, Malissa H.K Iida, Christine M Clarke, Barbara Doggett, Senji Shirasawa & Raj P Kapur. (2003) Genetic background modifies intestinal pseudo-obstruction and the expression of a reporter gene in Hox11L1−/− mice1 1The authors thank Carmen Booth for technical assistance and Kristy Seidel for statistical analysis.. Gastroenterology 125:5, pages 1428-1440.
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Shiwen Yang & Ludvik R. Donner. (2002) Detection of Ganglion Cells in the Colonic Plexuses by Immunostaining for Neuron-Specific Marker NeuN: an Aid for the Diagnosis of Hirschsprung Disease. Applied Immunohistochemistry & Molecular Morphology 10:3, pages 218-220.
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Shiwen Yang & Ludvik Donner. (2002) Applied Immunohistochemistry 10:3, pages 218-220.
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Raj P. Kapur. (2001) Neuropathology of paediatric chronic intestinal pseudo-obstruction and related animal models. The Journal of Pathology 194:3, pages 277-288.
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William A. Meier-Ruge & Luzia A. Brunner. (2019) Morphometric Assessment of Hirschsprung's Disease: Associated Hypoganglionosis of the Colonic Myenteric Plexus. Pediatric and Developmental Pathology 4:1, pages 53-61.
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Long Li, Wang Yan-Xia, Wu Xia-Na & Zhang Jin-Zhe. (2000) Posterior sagittal approach: Megasigmoid resection and anal reconstruction for severe constipation and fecal incontinence after anoplasty. Journal of Pediatric Surgery 35:7, pages 1058-1062.
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Thilo Wedel, Uwe Roblick, Juliane Quoß, Thomas H. K. Schiedeck, Hans -Peter Bruch & Heinz -Jürgen Krammer. (1999) Intestinale Innervationsstörungen: Anatomische Grundlagen und DiagnostikIntestinal innervation disorders: Anatomical basis and diagnosis. Coloproctology 21:3-4, pages 101-108.
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Thilo Wedel, Uwe Roblick, Joachim Gleiß, Thomas Schiedeck, Hans-Peter Bruch, Wolfgang Kühnel & Heinz-Jürgen Krammer. (1999) Organization of the enteric nervous system in the human colon demonstrated by wholemount immunohistochemistry with special reference to the submucous plexus. Annals of Anatomy - Anatomischer Anzeiger 181:4, pages 327-337.
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A.F. Schärli & R. Sossai. (1998) Hypoganglionosis. Seminars in Pediatric Surgery 7:3, pages 187-191.
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Prem Puri & Tomas Wester. (1998) Intestinal Neuronal Dysplasia. Seminars in Pediatric Surgery 7:3, pages 181-186.
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C. L. Cord-Udy, V. V. Smith, S. Ahmed, R. A. Risdon & P. J. Milla. (1997) An Evaluation of the Role of Suction Rectal Biopsy in the Diagnosis of Intestinal Neuronal Dysplasia. Journal of Pediatric Gastroenterology &amp Nutrition 24:1, pages 1-6.
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J M Fell, V V Smith & P J Milla. (1996) Infantile chronic idiopathic intestinal pseudo-obstruction: the role of small intestinal manometry as a diagnostic tool and prognostic indicator.. Gut 39:2, pages 306-311.
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Hiromitsu Miura, Ryoji Ohi, Shang Wen Tseng & Tohru Takahashi. (1996) The structure of the transitional and aganglionic zones of Auerbach's plexus in patients with Hirschsprung's disease: A computer-assisted three-dimensional reconstruction study. Journal of Pediatric Surgery 31:3, pages 420-426.
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