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Clinical Toxicology Volume 49, 2011 - Issue 2
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Articles: Poisons Centres

Clinical course of repeated supratherapeutic ingestion of acetaminophen

Mohammed A. Alhelail;Department of Emergency Medicine, King Abdulaziz Medical City, Riyadh, Saudi ArabiaCorrespondence[email protected]
,
Jason A. Hoppe;Rocky Mountain Poison & Drug Center, Denver, USA
,
Sean H. Rhyee;School of Medicine, University of Colorado, Aurora, USA
&
Kennon J. Heard;Division of Medical Toxicology, University of Massachusetts Medical School, Worcester, USA
Pages 108-112 | Received 14 Aug 2010, Accepted 12 Jan 2011, Published online: 03 Mar 2011

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Omid Mehrpour, Christopher Hoyte, Foster Goss, Farshad M. Shirazi & Samaneh Nakhaee. (2023) Decision tree algorithm can determine the outcome of repeated supratherapeutic ingestion (RSTI) exposure to acetaminophen: review of 4500 national poison data system cases. Drug and Chemical Toxicology 46:4, pages 692-698.
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Annabelle S Chidiac, Nicholas A Buckley, Firouzeh Noghrehchi & Rose Cairns. (2023) Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease. Expert Opinion on Drug Metabolism & Toxicology 19:5, pages 297-317.
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Slobodan M. Janković. (2022) Acetaminophen toxicity and overdose: current understanding and future directions for NAC dosing regimens. Expert Opinion on Drug Metabolism & Toxicology 18:11, pages 745-753.
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Michael Ganetsky, Anders H. Berg, Joshua J. Solano & Steven D. Salhanick. (2020) Metabolomic analysis of acetaminophen induced subclinical liver injury. Clinical Toxicology 58:8, pages 804-812.
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Harry Egan, Geoffrey K. Isbister, Jennifer Robinson, Michael Downes, Betty S. Chan, Elia Vecellio & Angela L. Chiew. (2019) Retrospective evaluation of repeated supratherapeutic ingestion (RSTI) of paracetamol. Clinical Toxicology 57:8, pages 703-711.
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Articles from other publishers (10)

Muhammad Adnan Haider, Yousra S. Gheit, Talwinder Nagi, Charles Vallejo, Zoilo K. Suarez, Oscar L. Hernandez, Polina Gaisinskaya & Nathan Markwart. (2023) Severe Acetaminophen Toxicity From the Use of Oxycodone-Acetaminophen With Normal Liver Function Tests and a Completely Asymptomatic Course of Hospitalization. ACG Case Reports Journal 10:8, pages e01126.
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Omid Mehrpour, Christopher Hoyte, Samaneh Nakhaee, Bruno Megarbane & Foster Goss. (2023) Using a decision tree algorithm to distinguish between repeated supra-therapeutic and acute acetaminophen exposures. BMC Medical Informatics and Decision Making 23:1.
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Anna Licata, Maria Giovanna Minissale, Simona Stankevičiūtė, Judith Sanabria-Cabrera, Maria Isabel Lucena, Raul J Andrade & Piero Luigi Almasio. (2022) N-Acetylcysteine for Preventing Acetaminophen-Induced Liver Injury: A Comprehensive Review. Frontiers in Pharmacology 13.
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Fu-Chao Liu, Huang-Ping Yu, Chia-Chih Liao, An-Hsun Chou & Hung-Chen Lee. (2021) The Timing and Effects of Low-Dose Ethanol Treatment on Acetaminophen-Induced Liver Injury. Life 11:10, pages 1094.
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Nga T. Nguyen, Jephte Y. Akakpo, James L. Weemhoff, Anup Ramachandran, Wen-Xing Ding & Hartmut Jaeschke. (2021) Impaired protein adduct removal following repeat administration of subtoxic doses of acetaminophen enhances liver injury in fed mice. Archives of Toxicology 95:4, pages 1463-1473.
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Andis Graudins & Anselm Wong. (2019) Paracetamol overdose: limiting the potential for harm. Medical Journal of Australia 211:5, pages 211-212.
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Michael Ganetsky, Anders H. Berg, Joshua J. Solano & Steven Salhanick. (2018) Inhibition of CYP2E1 With Propylene Glycol Does Not Protect Against Hepatocellular Injury in Human Acetaminophen Daily‐Dosing Model. The Journal of Clinical Pharmacology 59:1, pages 131-138.
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Paul Acheampong & Simon H. L. Thomas. (2016) Determinants of hepatotoxicity after repeated supratherapeutic paracetamol ingestion: systematic review of reported cases. British Journal of Clinical Pharmacology 82:4, pages 923-931.
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Vikhyat S. Bebarta, Drew C. Shiner & Shawn M. Varney. (2014) A Case of Moderate Liver Enzyme Elevation After Acute Acetaminophen Overdose Despite Undetectable Acetaminophen Level and Normal Initial Liver Enzymes. American Journal of Therapeutics 21:3, pages e82-e84.
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Michael J. Hodgman & Alexander R. Garrard. (2012) A Review of Acetaminophen Poisoning. Critical Care Clinics 28:4, pages 499-516.
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