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Clinical Toxicology Volume 49, 2011 - Issue 5
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Research article

The combination of cobinamide and sulfanegen is highly effective in mouse models of cyanide poisoning

Adriano ChanDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA;Medicine Service, VA San Diego Healthcare System, San Diego, CA, USA
,
Daune L. CrankshawCenter for Drug Design, University of Minnesota, Minneapolis, MN, USA
,
Alexandre MonteilCenter for Drug Design, University of Minnesota, Minneapolis, MN, USA
,
Steven E. PattersonCenter for Drug Design, University of Minnesota, Minneapolis, MN, USA
,
Herbert T. NagasawaCenter for Drug Design, University of Minnesota, Minneapolis, MN, USA
,
Jackie E. BriggsCenter for Drug Design, University of Minnesota, Minneapolis, MN, USA
,
Joseph A. KozocasSRI International, Menlo Park, CA, USA
,
Sari B. MahonBeckman Laser Institute and Medical Clinic, University of California, Irvine, CA, USA
,
Matthew BrennerBeckman Laser Institute and Medical Clinic, University of California, Irvine, CA, USA
,
Renate B. PilzDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA
,
Timothy D. BigbyDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA;Medicine Service, VA San Diego Healthcare System, San Diego, CA, USA
&
Gerry R. BossDepartment of Medicine, University of California, San Diego, La Jolla, CA, USACorrespondence[email protected]
 show all
Pages 366-373 | Received 03 Mar 2011, Accepted 26 Apr 2011, Published online: 08 Jul 2011

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D. S. Lippner, D. M. Hildenberger, M. O. Rhoomes, J. N. Winborn, H. Dixon, J. McDonough & G. A. Rockwood. (2022) A novel aqueous dimethyl trisulfide formulation is effective at low doses against cyanide toxicity in non-anesthetized mice and rats. Clinical Toxicology 60:1, pages 83-94.
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Adrian Thompson, Michael Dunn, Robert D Jefferson, Kosala Dissanayake, Frances Reed, Rachael Gregson, Stephen Greenhalgh, R Eddie Clutton, Peter G Blain, Simon HL Thomas & Michael Eddleston. (2020) Modest and variable efficacy of pre-exposure hydroxocobalamin and dicobalt edetate in a porcine model of acute cyanide salt poisoning. Clinical Toxicology 58:3, pages 190-200.
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Susan M. DeLeon, Jason D. Downey, Diane M. Hildenberger, Melissa O. Rhoomes, Lamont Booker, Gary A. Rockwood & Kelly A. Basi. (2018) DMTS is an effective treatment in both inhalation and injection models for cyanide poisoning using unanesthetized mice. Clinical Toxicology 56:5, pages 332-341.
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Articles from other publishers (22)

Matthew M Behymer, Huaping Mo, Naoaki Fujii, Vallabh Suresh, Ari S Arzumanian, Adriano Chan, Anjali K Nath, Robyn McCain, Calum A MacRae, Randall Peterson, Gerry R Boss, Vincent Jo Davisson & Gregory T Knipp. (2023) Investigating the replacement of carboxylates with carboxamides to modulate the safety and efficacy of platinum(II) thioether cyanide scavengers. Toxicological Sciences.
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Johanna M. Gretarsdottir, Ian H. Lambert, Stefan Sturup & Sigridur G. Suman. (2022) In Vitro Characterization of a Threonine-Ligated Molybdenyl–Sulfide Cluster as a Putative Cyanide Poisoning Antidote; Intracellular Distribution, Effects on Organic Osmolyte Homeostasis, and Induction of Cell Death . ACS Pharmacology & Translational Science 5:10, pages 907-918.
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Jason R. Nielson, Anjali K. Nath, Kim P. Doane, Xu Shi, Jangwoen Lee, Emily G. Tippetts, Kusumika Saha, Jordan Morningstar, Kevin G. Hicks, Adriano Chan, Yanbin Zhao, Amy Kelly, Tara B. Hendry-Hofer, Alyssa Witeof, Patrick Y. Sips, Sari Mahon, Vikhyat S. Bebarta, Vincent Jo Davisson, Gerry R. Boss, Jared Rutter, Calum A. MacRae, Matthew Brenner, Robert E. Gerszten & Randall T. Peterson. (2022) Glyoxylate protects against cyanide toxicity through metabolic modulation. Scientific Reports 12:1.
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Brandán Pedre & Tobias P. Dick. (2021) 3-Mercaptopyruvate sulfurtransferase: an enzyme at the crossroads of sulfane sulfur trafficking. Biological Chemistry 402:3, pages 223-237.
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Joseph K. Dzisam, Matthew Brenner, Sari B. Mahon, Gary A. Rockwood & Brian A. Logue. (2019) Determination of free cyano-cobinamide in swine and rabbit plasma by liquid chromatography tandem mass spectrometry. Journal of Chromatography B 1124, pages 100-108.
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V. D. Gladkikh & G. V. Vershinina. (2019) POTENTIAL DIRECTIONS OF THE IMPROVEMENT OF ANTIDOTE THERAPY OF CYANIDE POISONING. Toxicological Review:3, pages 46-50.
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Tara B. Hendry-Hofer, Patrick C. Ng, Alyssa E. Witeof, Sari B. Mahon, Matthew Brenner, Gerry R. Boss & Vikhyat S. Bebarta. (2018) A Review on Ingested Cyanide: Risks, Clinical Presentation, Diagnostics, and Treatment Challenges. Journal of Medical Toxicology 15:2, pages 128-133.
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Xinpeng Jiang, Guizhou Li & Chuanming Yu. (2018) Synthesis of N-aryl-3-(arylimino)-3H-indol-2-amines via hypervalent iodine promoted oxidative diamination of indoles. Tetrahedron Letters 59:15, pages 1506-1510.
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B.J. Day, J.L. Borowitz, S. Mukhopadhyay & G.E. Isom. 2018. Comprehensive Toxicology. Comprehensive Toxicology 541 556 .
Vikhyat S. Bebarta, Matthew Brittain, Adriano Chan, Norma Garrett, David Yoon, Tanya Burney, David Mukai, Michael Babin, Renate B. Pilz, Sari B. Mahon, Matthew Brenner & Gerry R. Boss. (2017) Sodium Nitrite and Sodium Thiosulfate Are Effective Against Acute Cyanide Poisoning When Administered by Intramuscular Injection. Annals of Emergency Medicine 69:6, pages 718-725.e4.
Crossref
Michael W Stutelberg, Alexandre R Monteil, Kumar G Belani, Bryant Moeller, Harpreet Singh, Navneet Kaur, Simranjit S Sra, David S Beebe, Steven E Patterson & Brian A Logue. (2017) Pharmacokinetics of next generation cyanide antidote sulfanegen in rabbits. International Journal of Pharmacokinetics 2:2, pages 105-111.
Crossref
Bryant M. Moeller, Daune L. Crankshaw, Jacquie Briggs, Herbert T. Nagasawa & Steven E. Patterson. (2017) In-vitro mercaptopyruvate sulfurtransferase species comparison in humans and common laboratory animals. Toxicology Letters 274, pages 64-68.
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Jangwoen Lee, Sari B. Mahon, David Mukai, Tanya Burney, Behdod S. Katebian, Adriano Chan, Vikhyat S. Bebarta, David Yoon, Gerry R. Boss & Matthew Brenner. (2016) The Vitamin B12 Analog Cobinamide Is an Effective Antidote for Oral Cyanide Poisoning. Journal of Medical Toxicology 12:4, pages 370-379.
Crossref
Jingjing Jiang, Adriano Chan, Sameh Ali, Arindam Saha, Kristofer J. Haushalter, Wai-Ling Macrina Lam, Megan Glasheen, James Parker, Matthew Brenner, Sari B. Mahon, Hemal H. Patel, Rajesh Ambasudhan, Stuart A. Lipton, Renate B. Pilz & Gerry R. Boss. (2016) Hydrogen Sulfide—Mechanisms of Toxicity and Development of an Antidote. Scientific Reports 6:1.
Crossref
Michael W. Stutelberg, Joseph K. Dzisam, Alexandre R. Monteil, Ilona Petrikovics, Gerry R. Boss, Steven E. Patterson, Gary A. Rockwood & Brian A. Logue. (2016) Simultaneous determination of 3-mercaptopyruvate and cobinamide in plasma by liquid chromatography–tandem mass spectrometry. Journal of Chromatography B 1008, pages 181-188.
Crossref
Mark E. Keim. 2016. Ciottone's Disaster Medicine. Ciottone's Disaster Medicine 664 670 .
Matthew Brenner, Sari Mahon-Brenner, Steven E. Patterson, Gary A. Rockwood & Gerry R. Boss. 2015. Toxicology of Cyanides and Cyanogens. Toxicology of Cyanides and Cyanogens 309 316 .
Adriano Chan, Jingjing Jiang, Alla Fridman, Ling T. Guo, G. Diane Shelton, Ming-Tao Liu, Carol Green, Kristofer J. Haushalter, Hemal H. Patel, Jangwoen Lee, David Yoon, Tanya Burney, David Mukai, Sari B. Mahon, Matthew Brenner, Renate B. Pilz & Gerry R. Boss. (2015) Nitrocobinamide, a New Cyanide Antidote That Can Be Administered by Intramuscular Injection. Journal of Medicinal Chemistry 58:4, pages 1750-1759.
Crossref
Akinde F. Kadjo, Purnendu K. Dasgupta & Gerry R. Boss. (2015) Comment on “Rapid visual detection of blood cyanide” by C. Männel-Croisé and F. Zelder, Analytical Methods, 2012, 4 , 2632 . Analytical Methods 7:13, pages 5707-5711.
Crossref
Keith ó Proinsias, Maksymilian Karczewski, Anna Zieleniewska & Dorota Gryko. (2014) Microwave-Assisted Cobinamide Synthesis. The Journal of Organic Chemistry 79:16, pages 7752-7757.
Crossref
Brendan L. Mitchell, Raj K. Bhandari, Vikhyat S. Bebarta, Gary A. Rockwood, Gerry R. Boss & Brian A. Logue. (2013) Toxicokinetic profiles of α-ketoglutarate cyanohydrin, a cyanide detoxification product, following exposure to potassium cyanide. Toxicology Letters 222:1, pages 83-89.
Crossref
D. S. Salnikov, I. A. Dereven’kov, E. N. Artyushina & S. V. Makarov. (2012) Interaction of cyanocobalamin with sulfur-containing reducing agents in aqueous solutions. Russian Journal of Physical Chemistry A 87:1, pages 44-48.
Crossref

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