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Clinical Toxicology Volume 50, 2012 - Issue 8
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Research Article

Effect of pirfenidone on pulmonary fibrosis due to paraquat poisoning in rats

Soroush SeifiradPulmonary and Critical Care Research Center, Tehran University of Medical Sciences, Tehran, Iran;Endocrinology and Metabolism Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranCorrespondence[email protected]
,
Amirhossein KeshavarzPulmonary and Critical Care Research Center, Tehran University of Medical Sciences, Tehran, Iran
,
Shervin TaslimiPulmonary and Critical Care Research Center, Tehran University of Medical Sciences, Tehran, Iran
,
Shima AranDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America
,
Hamidreza AbbasiPulmonary and Critical Care Research Center, Tehran University of Medical Sciences, Tehran, Iran
&
Alireza GhaffariDepartment of Internal Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Pages 754-758 | Received 08 Apr 2012, Accepted 02 Aug 2012, Published online: 27 Aug 2012

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Elisabeth Wigenstam, Linda Elfsmark, Lina Ågren, Christine Akfur, Anders Bucht & Sofia Jonasson. (2018) Anti-inflammatory and anti-fibrotic treatment in a rodent model of acute lung injury induced by sulfur dioxide. Clinical Toxicology 56:12, pages 1185-1194.
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T. Blanco-Ayala, A. C. Andérica-Romero & J. Pedraza-Chaverri. (2014) New insights into antioxidant strategies against paraquat toxicity. Free Radical Research 48:6, pages 623-640.
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Articles from other publishers (24)

Ying Lin, Zixin Wen, Yanxia Zhang, Jie shi, Juan Zhang, Xiuqin Li, Tianzi Jian, Yingying Zheng, Xiangdong Jian, Xiaorong Luan & Baotian Kan. (2023) Construction of a clinical nursing pathway for acute paraquat poisoning: Evidence-based research. Heliyon 9:4, pages e15447.
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Samar A. Antar, Mohamed A. Saleh & Ahmed A. Al-Karmalawy. (2022) Investigating the possible mechanisms of pirfenidone to be targeted as a promising anti-inflammatory, anti-fibrotic, anti-oxidant, anti-apoptotic, anti-tumor, and/or anti-SARS-CoV-2. Life Sciences 309, pages 121048.
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Rui Li, Yizhen Jia, Xiaohan Kong, Yichu Nie, Yang Deng & Yang Liu. (2022) Novel drug delivery systems and disease models for pulmonary fibrosis. Journal of Controlled Release 348, pages 95-114.
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Jyoti Aggarwal, AmtojSingh Lamba, Saurabh Gaba & Monica Gupta. (2022) Paraquat-induced lung fibrosis and multiorgan failure: A case report from North India. Indian Journal of Community and Family Medicine 8:1, pages 73.
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Soroush Seifirad & Lance Alquran. (2021) Commentary: Antifibrotics in COVID-19 Lung Disease: Let Us Stay Focused. Frontiers in Medicine 7.
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Soroush Seifirad. (2020) Pirfenidone: A novel hypothetical treatment for COVID-19. Medical Hypotheses 144, pages 110005.
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Rokhsana Rasooli, Younes Kamali & Ali Mandegary. (2020) Effects of pirfenidone, vitamin E, and pirfenidone–vitamin E combination in paraquat-induced pulmonary fibrosis. Comparative Clinical Pathology 29:3, pages 667-673.
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Seyedehparvin Khazraei, Sayed Mahdi Marashi & Hossein Sanaei-Zadeh. (2019) Ventilator settings and outcome of respiratory failure in paraquat-induced pulmonary injury. Scientific Reports 9:1.
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Marcia Rodrigues da Silva, Adriana Schapochnik, Mayara Peres Leal, Janete Esteves, Cristina Bichels Hebeda, Silvana Sandri, Christiane Pavani, Anna Carolina Ratto Tempestini Horliana, Sandra H. P. Farsky & Adriana Lino-dos-Santos-Franco. (2018) Beneficial effects of ascorbic acid to treat lung fibrosis induced by paraquat. PLOS ONE 13:11, pages e0205535.
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Francesca Lunardi, Federica Pezzuto, Stefania Edith Vuljan & Fiorella Calabrese. (2018) Idiopathic Pulmonary Fibrosis and Antifibrotic Treatments: Focus on Experimental Studies. Archives of Pathology & Laboratory Medicine 142:9, pages 1090-1097.
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Fateme Pourgholamhossein, Rokhsana Rasooli, Mostafa Pournamdari, Leyla Pourgholi, Mitra Samareh-Fekri, Mahmoud Ghazi-Khansari, Maryam Iranpour, Hamid-Reza Poursalehi, Mahmoud-Reza Heidari & Ali Mandegary. (2018) Pirfenidone protects against paraquat-induced lung injury and fibrosis in mice by modulation of inflammation, oxidative stress, and gene expression. Food and Chemical Toxicology 112, pages 39-46.
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SY Feng, J Gao, J Wang & Y Li. (2017) Effects of prolonged methylprednisolone treatment after pulse therapy for paraquat-intoxicated rats. Human & Experimental Toxicology 37:1, pages 21-26.
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Jianshe Ma, Fa Sun, Bingbao Chen, Xiaoting Tu, Xiufa Peng, Congcong Wen, Lufeng Hu & Xianqin Wang. (2017) Tissue metabolic changes for effects of pirfenidone in rats of acute paraquat poisoning by GC-MS. Toxicology and Industrial Health 33:12, pages 887-900.
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Gang Wang, Hao Jiao, Jun-Nian Zheng & Xia Sun. (2017) HSP27 regulates TGF-β mediated lung fibroblast differentiation through the Smad3 and ERK pathways. International Journal of Molecular Medicine 39:1, pages 183-190.
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J Qian, L Liu, L Chen, X Lu & C Zhu. (2014) Increased toll-like receptor 9 expression is associated with the severity of paraquat-induced lung injury in mice. Human & Experimental Toxicology 34:4, pages 430-438.
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Atsushi Yamada, Toshihiko Aki, Kana Unuma, Takeshi Funakoshi & Koichi Uemura. (2015) Paraquat Induces Epithelial-Mesenchymal Transition-Like Cellular Response Resulting in Fibrogenesis and the Prevention of Apoptosis in Human Pulmonary Epithelial Cells. PLOS ONE 10:3, pages e0120192.
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Soroush Seifirad, Alireza Ghaffari & Mahsa M. Amoli. (2014) The antioxidants dilemma: are they potentially immunosuppressants and carcinogens?. Frontiers in Physiology 5.
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Wei Ge, Hai-lian Wang & Ruo-peng Sun. (2013) Clinical Characteristics of Paraquat Poisoning in 22 Chinese Children. The Indian Journal of Pediatrics 81:7, pages 670-674.
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Ayşen Yeşim Yalçın. (2014) The relation of radiation-induced pulmonary fibrosis with stress and the efficiency of antioxidant treatment: An experimental study. Medical Science Monitor 20, pages 290-296.
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Soroush Seifirad & Farzad Masoudkabir. (2013) Apelin could reduce risk of contrast-induced nephropathy in patients with congestive heart failure. Medical Hypotheses 81:5, pages 898-900.
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H Zhang, P Liu, P Qiao, J Zhou, Y Zhao, X Xing & G Li. (2013) CT imaging as a prognostic indicator for patients with pulmonary injury from acute paraquat poisoning. The British Journal of Radiology 86:1026, pages 20130035.
Crossref
Soroush Seifirad. (2013) Pirfenidone could decrease paraquat-induced pulmonary fibrosis in rats. Tzu Chi Medical Journal 25:2, pages 130.
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Yu Peng, Huixiang Yang, Tingting Zhu, Menghua Zhao, Yuexia Deng, Bin Liu, Hong Shen, Gaoyun Hu, Zhaohe Wang & Lijian Tao. (2013) The antihepatic fibrotic effects of fluorofenidone via MAPK signalling pathways . European Journal of Clinical Investigation 43:4, pages 358-368.
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In O SunKwang Young Lee. (2013) Cyclophosphamide dose: how much is needed to win the war against paraquat poisoning?. The Korean Journal of Internal Medicine 28:4, pages 410.
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