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Clinical Toxicology Volume 50, 2012 - Issue 9
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Hemorrhagic complications associated with dabigatran use

Betty C. ChenNew York City Poison Control Center, Bellevue Hospital Center, New York University, New York, USACorrespondence[email protected]
,
Aaron D. VinyDepartment of Medicine, Weill Cornell Medical Center, New York, USA
,
Fiona M. GarlichNew York City Poison Control Center, Bellevue Hospital Center, New York University, New York, USA
,
Paul BascianoDivision of Hematology and Oncology, Weill Cornell Medical Center, New York, USA
,
Mary Ann HowlandNew York City Poison Control Center, Bellevue Hospital Center, New York University, New York, USA;St. John's University College of Pharmacy, New York, USA
,
Silas W. SmithNew York City Poison Control Center, Bellevue Hospital Center, New York University, New York, USA
,
Robert S. HoffmanNew York City Poison Control Center, Bellevue Hospital Center, New York University, New York, USA
&
Lewis S. NelsonNew York City Poison Control Center, Bellevue Hospital Center, New York University, New York, USA
 show all
Pages 854-857 | Received 27 Jun 2012, Accepted 13 Aug 2012, Published online: 12 Sep 2012

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Marie Linder, Anastasia Iliadou Nyman, Helle Kieler, Bengt Danielsson, Natalia Borg, Marcus Gry & Julius Collin. (2020) Assessing Safety of Direct Thrombin Inhibitors, Direct Factor Xa Inhibitors and Vitamin K Antagonists in Patients with Atrial Fibrillation: A Nation-Wide Propensity Score Matched Cohort from Sweden. Clinical Epidemiology 12, pages 1029-1038.
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Josée Bouchard, Marc Ghannoum, Amélie Bernier-Jean, David Williamson, Geoffrey Kershaw, Claire Weatherburn, Josette M. Eris, Huyen Tran, Jignesh P. Patel & Darren M. Roberts. (2015) Comparison of intermittent and continuous extracorporeal treatments for the enhanced elimination of dabigatran. Clinical Toxicology 53:3, pages 156-163.
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Articles from other publishers (37)

Brittany Salter & Mark Crowther. (2022) A Historical Perspective on the Reversal of Anticoagulants. Seminars in Thrombosis and Hemostasis 48:08, pages 955-970.
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J P K Ho, N Bari & F Riffat. (2020) Management of epistaxis in patients on novel oral anticoagulation therapy. The Journal of Laryngology & Otology 134:4, pages 316-322.
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James M. Feeney. 2020. Surgical Decision Making in Geriatrics. Surgical Decision Making in Geriatrics 329 337 .
Zain Ul Abideen Asad, Sardar Hassan Ijaz, Amna Mohyud Din Chaudhary, Safi U. Khan & Aneesh Pakala. (2019) Hemorrhagic Cardiac Tamponade Associated with Apixaban: A Case Report and Systematic Review of Literature. Cardiovascular Revascularization Medicine 20:11, pages 15-20.
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Jenna Smith, Jennifer Hanson, Raiyan Chowdhury & Tammy J. Bungard. (2019) Community-based management of epistaxis: Who bloody knows?. Canadian Pharmacists Journal / Revue des Pharmaciens du Canada 152:3, pages 164-176.
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V. L’Huillier, C. Badet & L. Tavernier. (2018) Épistaxis compliquant un traitement par anti-vitamine K et nouveaux anticoagulants oraux. Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale 135:4, pages 225-229.
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V. L’Huillier, C. Badet & L. Tavernier. (2018) Epistaxis complicating treatment by anti-vitamin K and new oral anticoagulants. European Annals of Otorhinolaryngology, Head and Neck Diseases 135:4, pages 231-235.
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Claudia Stöllberger, Maria Heger & Josef Finsterer. (2017) Hemopericardium under dabigatran for stroke prevention in atrial fibrillation. Blood Coagulation & Fibrinolysis 28:2, pages 185-188.
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James M. Feeney, Matthew Neulander, Monica DiFiori, Lilla Kis, David S. Shapiro, Vijay Jayaraman, William T. MarshallIIIIII & Stephanie C. Montgomery. (2017) Direct oral anticoagulants compared with warfarin in patients with severe blunt trauma. Injury 48:1, pages 47-50.
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M.L. Quan, P.W. Glunz & J.M. Smallheer. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III 600 627 .
Karl-Heinz Liesenfeld, Fredrik Gruenenfelder & Andreas Clemens. (2016) Enhanced elimination of dabigatran: Identifying the appropriate patient for the use of continuous venovenous hemodialysis instead of intermittent hemodialysis-A simulation analysis. The Journal of Clinical Pharmacology 56:5, pages 597-608.
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Ji-young Kim, Ok-Cheol Jeon, Hyun Tae Moon, Seung Rim Hwang & Youngro Byun. (2016) Preclinical safety evaluation of low molecular weight heparin-deoxycholate conjugates as an oral anticoagulant. Journal of Applied Toxicology 36:1, pages 76-93.
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Hisanao Akiyama, Kenji Uchino & Yasuhiro Hasegawa. (2015) Characteristics of Symptomatic Intracranial Hemorrhage in Patients Receiving Non-Vitamin K Antagonist Oral Anticoagulant Therapy. PLOS ONE 10:7, pages e0132900.
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Julie Kalabalik, Gail B. Rattinger, Jesse Sullivan, Malgorzata Slugocki, Antonia Carbone & Anastasia Rivkin. (2015) Use of Non-Vitamin K Antagonist Oral Anticoagulants in Special Patient Populations with Nonvalvular Atrial Fibrillation: A Review of the Literature and Application to Clinical Practice. Drugs 75:9, pages 979-998.
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Manish K. Kasliwal, Nicholas G. Panos, Lorenzo F. Munoz, Roham Moftakhar, Demetrius K. Lopes & Richard W. Byrne. (2015) Outcome following intracranial hemorrhage associated with novel oral anticoagulants. Journal of Clinical Neuroscience 22:1, pages 212-215.
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Inmaculada Hernandez, Seo Hyon Baik, Antonio Piñera & Yuting Zhang. (2015) Risk of Bleeding With Dabigatran in Atrial Fibrillation. JAMA Internal Medicine 175:1, pages 18.
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Francisco Javier García Callejo, Carmen Bécares Martínez, Jordi Calvo González, Paz Martínez Beneyto, Marta Marco Sanz & Jaime Marco Algarra. (2014) Epistaxis y dabigatrán, nuevo anticoagulante oral no antagonista de la vitamina K. Acta Otorrinolaringológica Española 65:6, pages 346-354.
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Francisco Javier García Callejo, Carmen Bécares Martínez, Jordi Calvo González, Paz Martínez Beneyto, Marta Marco Sanz & Jaime Marco Algarra. (2014) Epistaxis and Dabigatran, a New Non-Vitamin K Antagonist Oral Anticoagulant. Acta Otorrinolaringologica (English Edition) 65:6, pages 346-354.
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Matthew L. Moorman, Joshua E. Nash & Katie L. Stabi. (2014) Emergency surgery and trauma in patients treated with the new oral anticoagulants. Journal of Trauma and Acute Care Surgery 77:3, pages 486-494.
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Claudia Stöllberger, Gabriele Krutisch & Josef Finsterer. (2014) Life-threatening epistaxis and red blood cell polyagglutination under dabigatran. Blood Coagulation & Fibrinolysis 25:4, pages 384-386.
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Joanne van RynJohanna Schurer, Monika Kink-Eiband & Andreas Clemens. (2014) Reversal of Dabigatran-induced Bleeding by Coagulation Factor Concentrates in a Rat-tail Bleeding Model and Lack of Effect on Assays of Coagulation. Anesthesiology 120:6, pages 1429-1440.
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Britney Ross, Melissa A. Miller, Kristen Ditch & Maichi Tran. (2014) Clinical Experience of Life-Threatening Dabigatran-Related Bleeding at a Large, Tertiary Care, Academic Medical Center: a Case Series. Journal of Medical Toxicology 10:2, pages 223-228.
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Marc Ghannoum & Thomas D. Nolin. (2014) What is the Role of Renal Replacement Therapy in the Setting of Dabigatran Toxicity?. Seminars in Dialysis 27:3, pages 223-226.
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Jan Hendrik Schaefer, Wendy Leung, Limin Wu, Elizabeth M Van Cott, Josephine Lok, Michael Whalen, Klaus van Leyen, Arne Lauer, Joanne van Ryn, Eng H Lo & Christian Foerch. (2014) Translational Insights into Traumatic Brain Injury Occurring during Dabigatran or Warfarin Anticoagulation. Journal of Cerebral Blood Flow & Metabolism 34:5, pages 870-875.
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Sascha Meyer dos Santos & Sebastian Harder. (2014) Benefit–Risk Assessment of Dabigatran in the Treatment of Stroke Prevention in Non-Valvular Atrial Fibrillation. Drug Safety 37:5, pages 295-307.
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Daniel Kim, Richard Barna, Mary Barna Bridgeman & Luigi Brunetti. (2013) Novel Oral Anticoagulants for Stroke Prevention in the Geriatric Population. American Journal of Cardiovascular Drugs 14:1, pages 15-29.
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A Carter, P Sarda, M George & S Corbett. (2014) Hip arthroplasty fatality related to dabigatran induced gastrointestinal haemorrhage. The Annals of The Royal College of Surgeons of England 96:1, pages e01-e03.
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Terry S. Kang, Ken Lord & Nancy Kunjukunju. (2014) SPONTANEOUS CHOROIDAL HEMORRHAGE IN A PATIENT ON DABIGATRAN ETEXILATE (PRADAXA). Retinal Cases & Brief Reports 8:3, pages 175-177.
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Claudia Stöllberger & Josef Finsterer. (2013) Concerns About the Use of New Oral Anticoagulants for Stroke Prevention in Elderly Patients with Atrial Fibrillation. Drugs & Aging 30:12, pages 949-958.
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P. Esnault, P.E. Gaillard, J. Cotte, P.J. Cungi, J. Beaume & B. Prunet. (2013) Haemodialysis before emergency surgery in a patient treated with dabigatran. British Journal of Anaesthesia 111:5, pages 776-777.
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Tripti Singh, Thin Thin Maw, Brian L. Henry, Núria M. Pastor-Soler, Mark L. Unruh, Kenneth R. Hallows & Thomas D. Nolin. (2013) Extracorporeal Therapy for Dabigatran Removal in the Treatment of Acute Bleeding. Clinical Journal of the American Society of Nephrology 8:9, pages 1533-1539.
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Felix Knauf, C. Michael Chaknos, Jeffrey S. Berns & Mark A. Perazella. (2013) Dabigatran and Kidney Disease. Clinical Journal of the American Society of Nephrology 8:9, pages 1591-1597.
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M.M. Samama, J. Conard & A. Lillo-Le Louët. (2013) Accidents hémorragiques des nouveaux anticoagulants oraux et examens de la coagulation. Journal des Maladies Vasculaires 38:4, pages 259-270.
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Diane Nitzki-George, Izabela Wozniak & Joseph A Caprini. (2013) Current State of Knowledge on Oral Anticoagulant Reversal Using Procoagulant Factors. Annals of Pharmacotherapy 47:6, pages 841-855.
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Luigi Brunetti & Farooq Bandali. (2013) Dabigatran: Is There a Role for Coagulation Assays in Guiding Therapy?. Annals of Pharmacotherapy 47:6, pages 828-840.
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Ahmed J. Awad, Brian P. Walcott, Christopher J. Stapleton, Vijay Yanamadala, Brian V. Nahed & Jean-Valery Coumans. (2013) Dabigatran, intracranial hemorrhage, and the neurosurgeon. Neurosurgical Focus 34:5, pages E7.
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. (2013) Aspirin/clopidogrel/dabigatran etexilate. Reactions Weekly 1433:1, pages 10-10.
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