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Clinical Toxicology Volume 50, 2012 - Issue 10
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Research Articles

Blood levels of phosphatidylethanol in pregnant women reporting positive alcohol ingestion, measured by an improved LC-MS/MS analytical method

Ho Seok KwakDepartment of Laboratory Medicine, Cheil General Hospital and Women's Healthcare Centre, Kwandong University School of Medicine, Seoul, Republic of Korea
,
Jung-Yeol HanDepartment of Obstetrics and Gynaecology, Korean Motherisk Program, Cheil General Hospital and Women's Healthcare Centre, Kwandong University School of Medicine, Seoul, Republic of Korea;Department of Obstetrics and Gynaecology, Cheil General Hospital and Women's Healthcare Centre, Kwandong University School of Medicine, Seoul, Republic of KoreaCorrespondence[email protected]
,
Hyun-Kyong AhnDepartment of Obstetrics and Gynaecology, Korean Motherisk Program, Cheil General Hospital and Women's Healthcare Centre, Kwandong University School of Medicine, Seoul, Republic of Korea;Department of Obstetrics and Gynaecology, Cheil General Hospital and Women's Healthcare Centre, Kwandong University School of Medicine, Seoul, Republic of Korea
,
Min-Hyoung KimDepartment of Obstetrics and Gynaecology, Cheil General Hospital and Women's Healthcare Centre, Kwandong University School of Medicine, Seoul, Republic of Korea
,
Hyun-Mee RyuDepartment of Obstetrics and Gynaecology, Cheil General Hospital and Women's Healthcare Centre, Kwandong University School of Medicine, Seoul, Republic of Korea
,
Moon-Young KimDepartment of Obstetrics and Gynaecology, Cheil General Hospital and Women's Healthcare Centre, Kwandong University School of Medicine, Seoul, Republic of Korea
,
Hee-Jung ChungDepartment of Laboratory Medicine, Cheil General Hospital and Women's Healthcare Centre, Kwandong University School of Medicine, Seoul, Republic of Korea
,
Dong-Hee ChoDepartment of Laboratory Medicine, Cheil General Hospital and Women's Healthcare Centre, Kwandong University School of Medicine, Seoul, Republic of Korea
,
Chan-Young ShinDepartment of Pharmacology, School of Medicine, Konkuk University, Seoul, Republic of Korea
,
Elvia Y. Velazquez-ArmentaPharmaReasons – Pharmacological Research & Applied Solutions, Toronto, Ontario, Canada
&
Alejandro A. Nava-OcampoPharmaReasons – Pharmacological Research & Applied Solutions, Toronto, Ontario, Canada;Department of Clinical Pharmacology & Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada;Division of Clinical Pharmacology & Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada
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Pages 886-891 | Received 04 Aug 2012, Accepted 25 Oct 2012, Published online: 31 Dec 2012

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Annika C Montag. (2016) Fetal alcohol-spectrum disorders: identifying at-risk mothers. International Journal of Women's Health 8, pages 311-323.
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Ho-Seok Kwak, Jung-Yeol Han, June-Seek Choi, Hyun-Kyong Ahn, Hyun-Mee Ryu, Hee-Jung Chung, Dong-Hee Cho, Chan-Young Shin, E. Yadira Velazquez-Armenta & Alejandro A. Nava-Ocampo. (2014) Characterization of phosphatidylethanol blood concentrations for screening alcohol consumption in early pregnancy. Clinical Toxicology 52:1, pages 25-31.
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Articles from other publishers (28)

Lisa Franceschetto, Matteo Perilli, Alessandro Cinquetti, Chiara Giraudo, Mario Gardi, Giovanni Cecchetto & Guido Viel. (2022) Phosphatidylethanol in Maternal or Neonatal Blood to Detect Alcohol Exposure during Pregnancy: A Systematic Review. Life 12:10, pages 1528.
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Alicia DiBattista, Svetlana Ogrel, Alex E. MacKenzie & Pranesh Chakraborty. (2022) Quantitation of phosphatidylethanols in dried blood spots to determine rates of prenatal alcohol exposure in Ontario. Alcoholism: Clinical and Experimental Research 46:2, pages 243-251.
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Ya Zhao, Xinnan Zhao, Tao Li, Xiao Wang, Cheng Zhong, Xiupin Wang & Peiwu Li. (2022) Identification of glycerophospholipids using self-built recognition software based on positive and negative ion high-resolution mass spectrometric fragmentation experiments. Talanta 238, pages 123006.
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Trine Finanger, Olav Spigset, Rolf W. Gråwe, Trine N. Andreassen, Trine N. Løkken, Trond O. Aamo, Guro E. Bratt, Kristin Tømmervik, Vibeke S. Langaas, Kristin Finserås, Kjell Å.B. Salvesen & Ragnhild B. Skråstad. (2021) Phosphatidylethanol as Blood Biomarker of Alcohol Consumption in Early Pregnancy: An Observational Study in 4,067 Pregnant Women. Alcoholism: Clinical and Experimental Research 45:4, pages 886-892.
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Charlie T Cheng, Enrique M Ostrea Jr, Joseph NB Alviedo, Felix P Banadera & Ronald L Thomas. (2020) Fatty acid ethyl esters in meconium: A biomarker of fetal alcohol exposure and effect. Experimental Biology and Medicine 246:4, pages 380-386.
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Jung Yeol Han, Hyun Kyong Ahn, June Seek Choi, Gye Jeong Yeom, So-Young Lee, Yoon Ha Kim, Dal Soo Hong, Seong Yeon Hong, Jeong Sup Yun, Hye Jin Jung, Hye Ji Jeon, Sung Hong Joo, Anna Choi & Eui Shik Jeong. (2019) Korean Mothersafe Center 10th Anniversary: Outcome and Future Prospects. Journal of The Korean Society of Maternal and Child Health 23:4, pages 209-219.
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Stefan Maxwell, Stephanie Thompson, Fadi Zakko & Luis A. Bracero. (2019) Screening for prenatal alcohol exposure and corresponding short-term neonatal outcomes. Reproductive Toxicology 85, pages 6-11.
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Anik Forest, Matthieu Ruiz, Bertrand Bouchard, Gabrielle Boucher, Olivier Gingras, Caroline Daneault, Isabelle Robillard Frayne, David Rhainds, Jean-Claude Tardif, John D. Rioux & Christine Des Rosiers. (2018) Comprehensive and Reproducible Untargeted Lipidomic Workflow Using LC-QTOF Validated for Human Plasma Analysis. Journal of Proteome Research 17:11, pages 3657-3670.
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Bart C. H. van der Nagel, Sophie Wassenaar, Soma Bahmany & Birgit C. P. Koch. (2018) Quantification of Phosphatidylethanols in Whole Blood as a Proxy for Chronic Alcohol Consumption, Using Ultra Performance Convergence Chromatography Tandem Mass Spectrometry. Therapeutic Drug Monitoring 40:2, pages 268-275.
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Trine Naalsund Andreassen, Hilde Havnen, Olav Spigset, Berit Margrethe Hasle Falch & Ragnhild Bergene Skråstad. (2018) High Throughput UPLC®-MSMS Method for the Analysis of Phosphatidylethanol (PEth) 16:0/18:1, a Specific Biomarker for Alcohol Consumption, in Whole Blood. Journal of Analytical Toxicology 42:1, pages 33-41.
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Luis A. Bracero, Stefan Maxwell, Afua Nyanin, Dara J. Seybold, April White & Mike Broce. (2017) Improving screening for alcohol consumption during pregnancy with phosphatidylethanol. Reproductive Toxicology 74, pages 104-107.
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Siming Wang, Ruiyue Yang, Fusui Ji, Hongxia Li, Jun Dong & Wenxiang Chen. (2017) Sensitive and precise monitoring of phosphatidylethanol in human blood as a biomarker for alcohol intake by ultrasound-assisted dispersive liquid-liquid microextraction combined with liquid chromatography tandem mass spectrometry. Talanta 166, pages 315-320.
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Xinyu Zhang, Feng Zheng, Zebin Lin, Sys Stybe Johansen, Tianfang Yu, Yuming Liu, Zhibin Huang, Jiaolun Li, Jie Yan & Yulan Rao. (2017) Simultaneous determination of ethanol's four types of non-oxidative metabolites in human whole blood by liquid chromatography tandem mass spectrometry. Analytica Chimica Acta 963, pages 68-75.
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Heidi Bager, Lars Porskjaer Christensen, Steffen Husby & Lene Bjerregaard. (2017) Biomarkers for the Detection of Prenatal Alcohol Exposure: A Review. Alcoholism: Clinical and Experimental Research 41:2, pages 251-261.
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Shahid Ullah, Anders Helander & Olof Beck. (2017) Identification and quantitation of phosphatidylethanols in oral fluid by liquid chromatography-tandem mass spectrometry. Clinical Chemistry and Laboratory Medicine (CCLM) 55:9.
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A. E. Petukhov, A. V. Nadezhdin, S. T. Bogstrand, E. A. Bryun, G. V. Ramenskaya, E. A. Koshkina, E. V. Mel’nik, A. V. Smirnov & E. Yu. Tetenova. (2017) The comparative analysis of the methods for the determination of phosphatidylethanol in blood as a biological marker of alcohol abuse. Sudebno-meditsinskaya ekspertiza 60:5, pages 23.
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Scott H. Stewart. 2017. Biomarkers in Liver Disease. Biomarkers in Liver Disease 527 544 .
David Oppolzer, Mário Barroso & Eugenia Gallardo. (2016) Bioanalytical procedures and developments in the determination of alcohol biomarkers in biological specimens. Bioanalysis 8:3, pages 229-251.
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Natalie Kummer, Ann-Sofie Ingels, Sarah M. R. Wille, Catherine Hanak, Paul Verbanck, Willy E. E. Lambert, Nele Samyn & Christophe P. Stove. (2015) Quantification of phosphatidylethanol 16:0/18:1, 18:1/18:1, and 16:0/16:0 in venous blood and venous and capillary dried blood spots from patients in alcohol withdrawal and control volunteers. Analytical and Bioanalytical Chemistry 408:3, pages 825-838.
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Scott H. Stewart. 2016. Biomarkers in Liver Disease. Biomarkers in Liver Disease 1 18 .
Byron C. Calhoun. 2016. Tobacco Cessation and Substance Abuse Treatment in Women’s Healthcare. Tobacco Cessation and Substance Abuse Treatment in Women’s Healthcare 1 24 .
Jun-Young Yang, Ho-Seok Kwak, Jung-Yeol Han, June-Seek Choi, Hyun-Kyong Ahn, Young-Jun Oh, E. Yadira Velázquez-Armenta & Alejandro A. Nava-Ocampo. (2015) Could a first-trimester blood phosphatidylethanol concentration ⩾4 nM be useful to identify women with moderate-to-heavy prenatal alcohol exposure who are at high risk of adverse pregnancy outcomes?. Medical Hypotheses 85:6, pages 965-968.
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Pamela Cabarcos, Iván Álvarez, María Jesús Tabernero & Ana María Bermejo. (2015) Determination of direct alcohol markers: a review. Analytical and Bioanalytical Chemistry 407:17, pages 4907-4925.
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Radu Nanau & Manuela Neuman. (2015) Biomolecules and Biomarkers Used in Diagnosis of Alcohol Drinking and in Monitoring Therapeutic Interventions. Biomolecules 5:3, pages 1339-1385.
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Bom-Yi Lee, So-Yeon Park, Hyun-Mee Ryu, Chan-Young Shin, Ki-Nam Ko, Jung-Yeol Han, Gideon Koren & Youl-Hee Cho. (2015) Changes in the Methylation Status of DAT , SERT , and MeCP2 Gene Promoters in the Blood Cell in Families Exposed to Alcohol During the Periconceptional Period . Alcoholism: Clinical and Experimental Research 39:2, pages 239-250.
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Amitava Dasgupta. 2015. Alcohol and its Biomarkers. Alcohol and its Biomarkers 181 220 .
Ludmila N. Bakhireva, Lawrence Leeman, Renate D. Savich, Sandra Cano, Hilda Gutierrez, Daniel D. Savage & William F. Rayburn. (2014) The Validity of Phosphatidylethanol in Dried Blood Spots of Newborns for the Identification of Prenatal Alcohol Exposure. Alcoholism: Clinical and Experimental Research 38:4, pages 1078-1085.
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Theresa W. Gauthier, Danielle Giliberti, Sowmya S. Mohan, Juna Konomi & Lou Ann S. Brown. 2014. Alcohol Use Disorders and the Lung. Alcohol Use Disorders and the Lung 231 245 .

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