921
Views
34
CrossRef citations to date
0
Altmetric
Brief Communications

Metformin overdose-induced hypoglycemia in the absence of other antidiabetic drugs

, , &
Pages 444-447 | Received 06 Feb 2013, Accepted 07 Mar 2013, Published online: 01 Apr 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Jillian Theobald, Jamie Schneider, Navneet Cheema & Carol DesLauriers. (2020) Time to development of metformin-associated lactic acidosis. Clinical Toxicology 58:7, pages 758-762.
Read now
Xander M. R. Van Wijk, Robert Goodnough & Jennifer M. Colby. (2019) Mass spectrometry in emergency toxicology: Current state and future applications. Critical Reviews in Clinical Laboratory Sciences 56:4, pages 225-238.
Read now
Theodosios Filippatos, Eleftheria Tzavella, Christos Rizos, Moses Elisaf & George Liamis. (2017) Acid-base and electrolyte disorders associated with the use of antidiabetic drugs. Expert Opinion on Drug Safety 16:10, pages 1121-1132.
Read now
Luca Visconti, Valeria Cernaro, Domenico Ferrara, Giuseppe Costantino, Carmela Aloisi, Luisa Amico, Valeria Chirico, Domenico Santoro, Alberto Noto, Antonio David, Michele Buemi & Antonio Lacquaniti. (2016) Metformin-related lactic acidosis: is it a myth or an underestimated reality?. Renal Failure 38:9, pages 1560-1565.
Read now
Alessandro Protti. (2013) One other explanation for hypoglycemia during metformin overdose. Clinical Toxicology 51:6, pages 515-515.
Read now

Articles from other publishers (29)

Jae-Hong Joo, Hyun-Soo Zhang, Jiyeon Chun, Eun-Cheol Park & Sohee Park. (2023) Association of Metformin Treatment with Risk for Death in Diabetic Patients with Concomitant Gastric Cancer. Cancers 15:16, pages 4134.
Crossref
Yi Zhang, Fang Zhou, Jiaheng Guan, Lukun Zhou & Baoan Chen. (2023) Action Mechanism of Metformin and Its Application in Hematological Malignancy Treatments: A Review. Biomolecules 13:2, pages 250.
Crossref
Wen-Hsi Lan, Ting-Yu Lin, Jia-Ai Yeh, Chun-Lung Feng, Jun-Te Hsu, Hwai-Jeng Lin, Chia-Jung Kuo & Chih-Ho Lai. (2022) Mechanism Underlying Metformin Action and Its Potential to Reduce Gastric Cancer Risk. International Journal of Molecular Sciences 23:22, pages 14163.
Crossref
Deven Juneja, Prashant Nasa & Ravi Jain. (2022) Metformin toxicity: A meta-summary of case reports. World Journal of Diabetes 13:8, pages 654-664.
Crossref
Omid Mehrpour, Farhad Saeedi, Christopher Hoyte, Foster Goss & Farshad M. Shirazi. (2022) Utility of support vector machine and decision tree to identify the prognosis of metformin poisoning in the United States: analysis of National Poisoning Data System. BMC Pharmacology and Toxicology 23:1.
Crossref
Minakshi Bedi, Manju Ray & Alok Ghosh. (2021) Active mitochondrial respiration in cancer: a target for the drug. Molecular and Cellular Biochemistry 477:2, pages 345-361.
Crossref
Crystal Ives Tallman, Yu Zhang, Nicholas Black, Kara Lynch, Mohamed Fayed & Patil Armenian. (2022) Refractory vasodilatory shock secondary to metformin overdose supported with VA ECMO. Toxicology Reports 9, pages 64-67.
Crossref
Ayesha Akram. (2021) Reactive Hypoglycemia From Metformin Immediate-Release Monotherapy Resolved by a Switch to Metformin Extended-Release: Conceptualizing Their Concentration-Time Curves. Cureus.
Crossref
Uyen Vy Doan, Thanh Thao T. Nguyen, Thuy An Nguyen, Van Hoang Lam, Duong Tien Truong & Xuan T. Phan. (2021) Lactic acidosis had developed in diabetic patients receiving herbal therapy. MedPharmRes 5:2, pages 22-28.
Crossref
Chengchen Duan, Anna Evison, Lucy Taylor, Simone Onur, Karl Morten & Helen Townley. (2020) The common diabetes drug metformin can diminish the action of citral against Rhabdomyosarcoma cells in vitro. Phytotherapy Research 35:3, pages 1378-1388.
Crossref
Maricel Dela Cruz, Muhammed Ershad & Ahmed Mostafa. (2021) Metabolic acidosis and hyperlactatemia requiring continuous venovenous hemofiltration after intentional ingestion of metformin. Indian Journal of Nephrology 31:1, pages 77.
Crossref
Noura T. Shurrab & El-Shaimaa A. Arafa. (2020) Metformin: A review of its therapeutic efficacy and adverse effects. Obesity Medicine 17, pages 100186.
Crossref
George Sam Wang & Christopher Hoyte. (2018) Review of Biguanide (Metformin) Toxicity. Journal of Intensive Care Medicine 34:11-12, pages 863-876.
Crossref
Sarah Aldobeaban, Bandr Mzahim & Abdussalam Ali Alshehri. (2018) Recurrent hypoglycemia secondary to metformin toxicity in the absence of co-ingestions: a case report. Journal of Medical Case Reports 12:1.
Crossref
Tomoya Ikeda, Naoto Tani, Shigeki Oritani, Alissa Shida, Yayoi Aoki, Fumiya Morioka & Takaki Ishikawa. (2018) Toxicological and Biochemical Analyses of an Autopsy Case Involving Oral Overdose of Multiple Antidiabetic and Antihypertensive Drugs. Case Reports in Medicine 2018, pages 1-8.
Crossref
Eduardo Hernández-Vázquez, Sandra Young-Peralta, Litzia Cerón-Romero, Sara García-Jiménez & Samuel Estrada-Soto. (2018) Acute and subacute antidiabetic studies of ENP-9, a new 1,5-diarylpyrazole derivative. Journal of Pharmacy and Pharmacology 70:8, pages 1031-1039.
Crossref
Yu Ueda, Christine Wong & Angela Borchers. (2018) Severe lactic acidosis and hypoglycemia due to acute metformin intoxication in a dog. Journal of Veterinary Emergency and Critical Care 28:3, pages 274-278.
Crossref
Nicole Barrella, Beth Eisenberg & Stephanie Nicole Simpson. (2017) Hypoglycemia and severe lactic acidosis in a dog following metformin exposure. Clinical Case Reports 5:12, pages 2097-2104.
Crossref
F. Kajbaf & J.-D. Lalau. (2016) Cette metformine, si connue. Si méconnue pour ses taux thérapeutiques…. Médecine des Maladies Métaboliques 10:5, pages 471-474.
Crossref
D. Agterhuis, H. Freling, M. Henstra & Th.F. Veneman. (2016) Metformine-intoxicatie: een combinatie van ernstige hypoglykemie en lactaatacidose. Nederlands Tijdschrift voor Diabetologie 14:2, pages 49-51.
Crossref
Farshad Kajbaf, Marc E. De Broe & Jean-Daniel Lalau. (2015) Therapeutic Concentrations of Metformin: A Systematic Review. Clinical Pharmacokinetics 55:4, pages 439-459.
Crossref
John B. Buse, Ralph A. DeFronzo, Julio Rosenstock, Terri Kim, Colleen Burns, Sharon Skare, Alain Baron & Mark Fineman. (2016) The Primary Glucose-Lowering Effect of Metformin Resides in the Gut, Not the Circulation: Results From Short-term Pharmacokinetic and 12-Week Dose-Ranging Studies. Diabetes Care 39:2, pages 198-205.
Crossref
Ralph DeFronzo, G. Alexander Fleming, Kim Chen & Thomas A. Bicsak. (2016) Metformin-associated lactic acidosis: Current perspectives on causes and risk. Metabolism 65:2, pages 20-29.
Crossref
Diane P. Calello, Kathleen D. Liu, Timothy J. Wiegand, Darren M. Roberts, Valéry Lavergne, Sophie Gosselin, Robert S. Hoffman, Thomas D. Nolin & Marc Ghannoum. (2015) Extracorporeal Treatment for Metformin Poisoning. Critical Care Medicine 43:8, pages 1716-1730.
Crossref
K. McNamara & G. K. Isbister. (2015) Hyperlactataemia and clinical severity of acute metformin overdose. Internal Medicine Journal 45:4, pages 402-408.
Crossref
Dinette Agterhuis, Hanneke Freling, Margreet Henstra & Thiemo F. Veneman. (2015) Metformin Intoxication: A Case of a Combination of Severe Hypoglycaemia and Severe Lactic Acidosis (LA). Journal of Diabetes Mellitus 05:02, pages 111-114.
Crossref
S. Piel, J. K. Ehinger, E. Elmér & M. J. Hansson. (2015) Metformin induces lactate production in peripheral blood mononuclear cells and platelets through specific mitochondrial complex I inhibition. Acta Physiologica 213:1, pages 171-180.
Crossref
Alessandro Bonsignore, Fulvia Pozzi, Giulio Fraternali Orcioni, Francesco Ventura & Cristian Palmiere. (2013) Fatal metformin overdose: case report and postmortem biochemistry contribution. International Journal of Legal Medicine 128:3, pages 483-492.
Crossref
. (2013) Metformin/quetiapine overdose. Reactions Weekly 1458:1, pages 30-30.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.