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Review Article

Interpreting cobalt blood concentrations in hip implant patients

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Pages 98-112 | Received 24 Jun 2013, Accepted 11 Oct 2013, Published online: 20 Nov 2013

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Laura Leyssens, Bart Vinck, Catherine Van Der Straeten, Ingeborg Dhooge, Floris L. Wuyts & Leen K. Maes. (2021) The ototoxic potential of cobalt from metal-on-metal hip implants: a pilot study on the patient-reported auditory, vestibular, and general neurological outcome. International Journal of Audiology 60:1, pages 44-53.
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Noora Honkasaari, Olli Lainiala, Outi Laine, Aleksi Reito & Antti Eskelinen. (2020) No association between blood count levels and whole-blood cobalt and chromium levels in 1,900 patients with metal-on-metal hip arthroplasty. Acta Orthopaedica 91:6, pages 711-716.
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Michael Kovochich, Brent L. Finley, Rachel Novick, Andrew D. Monnot, Ellen Donovan, Kenneth M. Unice, Ernest S. Fung, David Fung & Dennis J. Paustenbach. (2018) Understanding outcomes and toxicological aspects of second generation metal-on-metal hip implants: a state-of-the-art review. Critical Reviews in Toxicology 48:10, pages 839-887.
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Kimberly A. Fox, Todd M. Phillips, Joseph H. Yanta & Michael G. Abesamis. (2016) Fatal cobalt toxicity after total hip arthroplasty revision for fractured ceramic components. Clinical Toxicology 54:9, pages 874-877.
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Brooke E. Tvermoes, Dennis J. Paustenbach, Brent D. Kerger, Brent L. Finley & Kenneth M. Unice. (2015) Review of cobalt toxicokinetics following oral dosing: Implications for health risk assessments and metal-on-metal hip implant patients. Critical Reviews in Toxicology 45:5, pages 367-387.
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Andrew D. Monnot, Whitney V. Christian, Dennis J. Paustenbach & Brent L. Finley. (2014) Correlation of blood Cr(III) and adverse health effects: Application of PBPK modeling to determine non-toxic blood concentrations. Critical Reviews in Toxicology 44:7, pages 618-637.
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Dennis Paustenbach, David Galbraith & Brent Finley. (2014) Authors’ Response to Letters to the Editor Re: Interpreting cobalt blood concentrations in hip implant patients. Clinical Toxicology 52:5, pages 569-570.
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John Devlin & Adam C. Pomerleau. (2014) Interpreting cobalt values after hip replacement: Should we treat the number or the patient?. Clinical Toxicology 52:5, pages 567-567.
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Brent L. Finley, Kenneth M. Unice, Brent D. Kerger, Joanne M. Otani, Dennis J. Paustenbach, David A. Galbraith & Brooke E. Tvermoes. (2013) 31-Day Study of Cobalt(II) Chloride Ingestion in Humans: Pharmacokinetics and Clinical Effects. Journal of Toxicology and Environmental Health, Part A 76:21, pages 1210-1224.
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Ilona Świątkowska, Obakanyin J. Akinfosile, Ravindra V. Badhe, Mark Barba, Mathew T. Mathew & Divya Bijukumar. 2023. Biomarkers of Hip Implant Function. Biomarkers of Hip Implant Function 205 247 .
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