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Clinical Toxicology Volume 52, 2014 - Issue 5
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Research Articles

The vitamin B12 analog cobinamide is an effective hydrogen sulfide antidote in a lethal rabbit model

M. BrennerBeckman Laser Institute, University of California, Irvine, CA, USA;Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, Irvine, CA, USACorrespondence[email protected]
,
S. BenavidesBeckman Laser Institute, University of California, Irvine, CA, USA
,
S. B. MahonBeckman Laser Institute, University of California, Irvine, CA, USA
,
J. LeeBeckman Laser Institute, University of California, Irvine, CA, USA
,
D. YoonBeckman Laser Institute, University of California, Irvine, CA, USA
,
D. MukaiBeckman Laser Institute, University of California, Irvine, CA, USA
,
M. ViseroiBeckman Laser Institute, University of California, Irvine, CA, USA
,
A. ChanDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA
,
J. JiangDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA
,
N. NarulaDepartment of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA
,
S. M. AzerBeckman Laser Institute, University of California, Irvine, CA, USA
,
C. AlexanderBeckman Laser Institute, University of California, Irvine, CA, USA
&
G. R. BossDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA
 show all
Pages 490-497 | Received 12 Dec 2013, Accepted 07 Mar 2014, Published online: 09 Apr 2014

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Cristina Santana Maldonado, Abigail Weir & Wilson K. Rumbeiha. (2023) A comprehensive review of treatments for hydrogen sulfide poisoning: past, present, and future. Toxicology Mechanisms and Methods 33:3, pages 183-196.
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George P. Philipopoulos, John Tat, Adriano Chan, Jingjing Jiang, David Mukai, Tanya Burney, Melody Doosty, Sari Mahon, Hemal H. Patel, Carl W. White, Matthew Brenner, Jangwoen Lee & Gerry R. Boss. (2022) Methyl mercaptan gas: mechanisms of toxicity and demonstration of the effectiveness of cobinamide as an antidote in mice and rabbits. Clinical Toxicology 60:5, pages 615-622.
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Philippe Haouzi & Takashi Sonobe. (2015) Cardiogenic shock induced reduction in cellular O2 delivery as a hallmark of acute H2S intoxication. Clinical Toxicology 53:4, pages 416-417.
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Denise Fernández, Melissa Legrand, Samer Abujaber & Lewis S. Nelson. (2015) Letter in response to “The Vitamin B12 analog cobinamide is an effective hydrogen sulfide antidote in a lethal rabbit model”. Clinical Toxicology 53:1, pages 73-73.
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Articles from other publishers (34)

Ilia A. Dereven’kov, Larissa A. Maiorova, Oscar I. Koifman & Denis S. Salnikov. (2023) High Reactivity of Supermolecular Nanoentities of a Vitamin B 12 Derivative in Langmuir–Schaefer Films Toward Gaseous Toxins . Langmuir 39:48, pages 17240-17250.
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Ilia A. Dereven’kov, Ilya I. Dzvinkas, Vladimir S. Osokin & Sergei V. Makarov. (2023) Effect of bovine serum albumin on the water solubility of hydrophobic corrinoids. Journal of Porphyrins and Phthalocyanines 27:05, pages 811-817.
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Giuseppe Cirino, Csaba Szabo & Andreas Papapetropoulos. (2023) Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs. Physiological Reviews 103:1, pages 31-276.
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Philippe Haouzi, Marissa MacCann, Matthew Brenner, Sari Mahon, Vikhyat S. Bebarta, Adriano Chan, Annick Judenherc-Haouzi, Nicole Tubbs & Gerry R. Boss. (2022) Treatment of life-threatening H2S intoxication: Lessons from the trapping agent tetranitrocobinamide. Environmental Toxicology and Pharmacology 96, pages 103998.
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Ilia A. Dereven’kov, Vladimir S. Osokin, Pavel A. Molodtsov, Anna S. Makarova & Sergei V. Makarov. (2022) Effect of complexation between cobinamides and bovine serum albumin on their reactivity toward cyanide. Reaction Kinetics, Mechanisms and Catalysis 135:3, pages 1469-1483.
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Yingying WangXiang NiRahuljeet ChadhaCaitlin McCartneyYannie LamBrock BrummettGeat RamushMing Xian. (2022) Methods for Suppressing Hydrogen Sulfide in Biological Systems. Antioxidants & Redox Signaling 36:4-6, pages 294-308.
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K. Veena Gayathri, S. Aishwarya, P. Senthil Kumar, U. Rohini Rajendran & K. Gunasekaran. (2021) Metabolic and molecular modelling of zebrafish gut biome to unravel antimicrobial peptides through metagenomics. Microbial Pathogenesis 154, pages 104862.
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Joshua J. Woods & Justin J. Wilson. 2011. Encyclopedia of Inorganic and Bioinorganic Chemistry. Encyclopedia of Inorganic and Bioinorganic Chemistry 1 22 .
Miriam M. Cortese-Krott. (2020) Red Blood Cells as a “Central Hub” for Sulfide Bioactivity: Scavenging, Metabolism, Transport, and Cross-Talk with Nitric Oxide. Antioxidants & Redox Signaling 33:18, pages 1332-1349.
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Eleni Dongó & Levente Kiss. (2020) The Potential Role of Hydrogen Sulfide in the Regulation of Cerebrovascular Tone. Biomolecules 10:12, pages 1685.
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Eizo Marutani & Fumito Ichinose. (2020) Emerging pharmacological tools to control hydrogen sulfide signaling in critical illness. Intensive Care Medicine Experimental 8:1.
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Tara B. Hendry‐Hofer, Patrick C. Ng, Alison M. McGrath, David Mukai, Matthew Brenner, Sari Mahon, Joseph K. Maddry, Gerry R. Boss & Vikhyat S. Bebarta. (2020) Intramuscular aminotetrazole cobinamide as a treatment for inhaled hydrogen sulfide poisoning in a large swine model. Annals of the New York Academy of Sciences 1479:1, pages 159-167.
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Philippe Haouzi, Takashi Sonobe & Annick Judenherc-Haouzi. (2020) Hydrogen sulfide intoxication induced brain injury and methylene blue. Neurobiology of Disease 133, pages 104474.
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Livia-Cristina Borcan, Florin Borcan, Elena-Ana Păuncu & Mirela Cleopatra Tomescu. (2019) Correlations between weather parameters, atmospheric hydrogen sulphide level and vitamin B12 administration to H 2 S exposed workers . Romanian Journal of Occupational Medicine 70:1, pages 6-11.
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Pierre P. Kamoun. (2019) Mental retardation in Down syndrome: Two ways to treat. Medical Hypotheses 131, pages 109289.
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Patrick C. Ng, Tara B. Hendry-Hofer, Alyssa E. Witeof, Matthew Brenner, Sari B. Mahon, Gerry R. Boss, Philippe Haouzi & Vikhyat S. Bebarta. (2019) Hydrogen Sulfide Toxicity: Mechanism of Action, Clinical Presentation, and Countermeasure Development. Journal of Medical Toxicology 15:4, pages 287-294.
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Chun‐tao Yang, Yingying Wang, Eizo Marutani, Tomoaki Ida, Xiang Ni, Shi Xu, Wei Chen, Hui Zhang, Takaaki Akaike, Fumito Ichinose & Ming Xian. (2019) Data‐Driven Identification of Hydrogen Sulfide Scavengers. Angewandte Chemie International Edition 58:32, pages 10898-10902.
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Chun‐tao Yang, Yingying Wang, Eizo Marutani, Tomoaki Ida, Xiang Ni, Shi Xu, Wei Chen, Hui Zhang, Takaaki Akaike, Fumito Ichinose & Ming Xian. (2019) Data‐Driven Identification of Hydrogen Sulfide Scavengers. Angewandte Chemie 131:32, pages 11014-11018.
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Jayshil J. Patel, Carla Venegas-Borsellino, Rodney Willoughby & Julie K. Freed. (2019) High-Dose Vitamin B12 in Vasodilatory Shock: A Narrative Review. Nutrition in Clinical Practice 34:4, pages 514-520.
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Philippe Haouzi, Nicole Tubbs, Joseph Cheung & Annick Judenherc-Haouzi. (2019) Methylene Blue Administration During and After Life-Threatening Intoxication by Hydrogen Sulfide: Efficacy Studies in Adult Sheep and Mechanisms of Action. Toxicological Sciences 168:2, pages 443-459.
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S. O. Tumakov, I. A. Dereven’kov, D. S. Sal’nikov & S. V. Makarov. (2019) Kinetics of the Reaction between Cobinamide and Isoniazid in Aqueous Solutions. Russian Journal of Physical Chemistry A 93:2, pages 265-270.
Crossref
Eleni Dongó, Gabriella Beliczai-Marosi, Ane Stensønes Dybvig & Levente Kiss. (2018) The mechanism of action and role of hydrogen sulfide in the control of vascular tone. Nitric Oxide 81, pages 75-87.
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Ilia A. Dereven'kov, Sergei V. Makarov, Thu Thuy Bui Thi, Anna S. Makarova & Oskar I. Koifman. (2018) Studies on the Reduction of Dehydroascorbic Acid by Glutathione in the Presence of Aquahydroxocobinamide. European Journal of Inorganic Chemistry 2018:25, pages 2987-2992.
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Beverly J. McEwen. 2018. Veterinary Forensic Pathology, Volume 1. Veterinary Forensic Pathology, Volume 1 129 148 .
Samantha L. Malone Rubright, Linda L. Pearce & Jim Peterson. (2017) Environmental toxicology of hydrogen sulfide. Nitric Oxide 71, pages 1-13.
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Richard J. Johnson, Benjamin D. Folwell, Alexander Wirekoh, Max Frenzel & Torben Lund Skovhus. (2017) Reservoir Souring – Latest developments for application and mitigation. Journal of Biotechnology 256, pages 57-67.
Crossref
Ilia A. Dereven’kov, Pavel A. Ivlev, Cristina Bischin, Denis S. Salnikov, Radu Silaghi-Dumitrescu, Sergei V. Makarov & Oscar I. Koifman. (2017) Comparative studies of reaction of cobalamin (II) and cobinamide (II) with sulfur dioxide. JBIC Journal of Biological Inorganic Chemistry 22:6, pages 969-975.
Crossref
Aaron Skolnik & C. William Heise. 2017. Critical Care Toxicology. Critical Care Toxicology 1963 1971 .
Lee A. Greenawald, Gerry R. Boss, Aaron Reeder & Suzanne Bell. (2016) Development of a hydrogen sulfide end-of-service-life indicator for respirator cartridges using cobinamide. Sensors and Actuators B: Chemical 230, pages 658-666.
Crossref
Jingjing Jiang, Adriano Chan, Sameh Ali, Arindam Saha, Kristofer J. Haushalter, Wai-Ling Macrina Lam, Megan Glasheen, James Parker, Matthew Brenner, Sari B. Mahon, Hemal H. Patel, Rajesh Ambasudhan, Stuart A. Lipton, Renate B. Pilz & Gerry R. Boss. (2016) Hydrogen Sulfide—Mechanisms of Toxicity and Development of an Antidote. Scientific Reports 6:1.
Crossref
I.A. Dereven’kov, D.S. Salnikov, R. Silaghi-Dumitrescu, S.V. Makarov & O.I. Koifman. (2016) Redox chemistry of cobalamin and its derivatives. Coordination Chemistry Reviews 309, pages 68-83.
Crossref
Aaron Skolnik & C. William Heise. 2016. Critical Care Toxicology. Critical Care Toxicology 1 10 .
Jean W. Wassenaar, Gerry R. Boss & Karen L. Christman. (2015) Decellularized skeletal muscle as an in vitro model for studying drug-extracellular matrix interactions. Biomaterials 64, pages 108-114.
Crossref
Stephen W. Borron. (2014) The Perfect Antidote. Academic Emergency Medicine 21:11, pages 1292-1294.
Crossref

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