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Clinical Toxicology Volume 53, 2015 - Issue 5
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Research Article

Fab fragments of ovine antibody to colchicine enhance its clearance in the rat

Philip W. PeakeDepartment of Nephrology, Prince of Wales Hospital, Sydney, Australia;Prince of Wales Clinical School, University of New South Wales, Sydney, AustraliaCorrespondence[email protected]
,
Timothy J. PiantaDepartment of Nephrology, Prince of Wales Hospital, Sydney, Australia;Prince of Wales Clinical School, University of New South Wales, Sydney, Australia
,
Lena SuccarDepartment of Nephrology, Prince of Wales Hospital, Sydney, Australia;Prince of Wales Clinical School, University of New South Wales, Sydney, Australia
,
Mangalee FernandoDepartment of Nephrology, Prince of Wales Hospital, Sydney, Australia;Prince of Wales Clinical School, University of New South Wales, Sydney, Australia
,
Nicholas A. BuckleyPrince of Wales Clinical School, University of New South Wales, Sydney, Australia
&
Zoltan H. EndreDepartment of Nephrology, Prince of Wales Hospital, Sydney, Australia;Prince of Wales Clinical School, University of New South Wales, Sydney, Australia
Pages 427-432 | Received 16 Dec 2014, Accepted 11 Mar 2015, Published online: 10 Apr 2015

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Michael Eddleston, Nicolas Fabresse, Adrian Thompson, Ibrahim Al Abdulla, Rachael Gregson, Tim King, Alain Astier, Frederic J. Baud, R Eddie Clutton & Jean-Claude Alvarez. (2018) Anti-colchicine Fab fragments prevent lethal colchicine toxicity in a porcine model: a pharmacokinetic and clinical study. Clinical Toxicology 56:8, pages 773-781.
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Articles from other publishers (7)

Elena Jerschke, Mikhail Barkovsky, Nicole Jung, Heidi Neuberger, Jochen Stenzel, Florian Eyer, Arne Skerra & Stefanie Geith. (2023) In vivo neutralization of colchicine toxicity by a PASylated anticalin in a rat model. Toxicology 492, pages 153526.
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Z. Boyadzhieva, N. Ruffer & M. Krusche. (2021) Colchicin: altes Medikament mit neuem NutzenColchicine: old medication with new benefits. Zeitschrift für Rheumatologie 80:7, pages 647-657.
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Kie Horioka, Hiroki Tanaka, Shotaro Isozaki, Hiroaki Konishi, Mikihiro Fujiya, Katsuhiro Okuda, Masaru Asari, Hiroshi Shiono, Katsuhiro Ogawa & Keiko Shimizu. (2019) Acute Colchicine Poisoning Causes Endotoxemia via the Destruction of Intestinal Barrier Function: The Curative Effect of Endotoxin Prevention in a Murine Model. Digestive Diseases and Sciences 65:1, pages 132-140.
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Mikhail Barkovskiy, Elena Ilyukhina, Martin Dauner, Andreas Eichinger & Arne Skerra. (2019) An engineered lipocalin that tightly complexes the plant poison colchicine for use as antidote and in bioanalytical applications. Biological Chemistry 400:3, pages 351-366.
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Hongzhen Zhong, Zhiqing Zhong, Hongyan Li, Tianbiao Zhou & Weiji Xie. (2018) A rare case report of heavy dose colchicine induced acute kidney injury. BMC Pharmacology and Toxicology 19:1.
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Nicolas Fabresse, Julien Allard, Marine Sardaby, Adrian Thompson, R. Eddie Clutton, Michael Eddleston & Jean-Claude Alvarez. (2017) LC–MS/MS quantification of free and Fab-bound colchicine in plasma, urine and organs following colchicine administration and colchicine-specific Fab fragments treatment in Göttingen minipigs. Journal of Chromatography B 1060, pages 400-406.
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Gorawit Yusakul, Seiichi Sakamoto, Hiroyuki Tanaka & Satoshi Morimoto. (2016) Efficient expression of single chain variable fragment antibody against paclitaxel using the Bombyx mori nucleopolyhedrovirus bacmid DNA system and its characterizations. Journal of Natural Medicines 70:3, pages 592-601.
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