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Critical Care

Tramadol overdose causes seizures and respiratory depression but serotonin toxicity appears unlikely

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Pages 545-550 | Received 11 Feb 2015, Accepted 26 Mar 2015, Published online: 22 Apr 2015

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Wendy Cheng, Rex Pui Kin Lam & Chi Keung Chan. (2022) Factors associated with seizure in tramadol overdose: a 12-year retrospective study in Hong Kong. Clinical Toxicology 60:11, pages 1220-1226.
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Akhona Fynn, Elvera Helberg, Brian Godman & Johanna C Meyer. (2020) Drug utilization review of tramadol hydrochloride in a regional hospital in South Africa; findings and implications. Hospital Practice 48:2, pages 92-99.
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Joomi Lee, Hee-Doo Yoo, Jung-Woo Bae, Sooyeun Lee & Kwang-Hee Shin. (2019) Population pharmacokinetic analysis of tramadol and O-desmethyltramadol with genetic polymorphism of CYP2D6. Drug Design, Development and Therapy 13, pages 1751-1761.
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Neeraj Chhabra, Erin M Pallasch, Michael Wahl & Sean M Bryant. (2019) Tramadol, naloxone, and seizures. Clinical Toxicology 57:12, pages 1160-1160.
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Brian Patrick Murray, Joseph E. Carpenter, Camille A. Dunkley, Tim P. Moran, Musa Alfaifi, Waleed S. Alsukaiti & Ziad Kazzi. (2019) Seizures in tramadol overdoses reported in the ToxIC registry: predisposing factors and the role of naloxone. Clinical Toxicology 57:8, pages 692-696.
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Nicole M. Ryan, Anne E. Vertigan & Surinder S. Birring. (2018) An update and systematic review on drug therapies for the treatment of refractory chronic cough. Expert Opinion on Pharmacotherapy 19:7, pages 687-711.
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Nuggehally R. Srinivas. (2015) Differential Consequences of Tramadol in Overdosing: Dilemma of a Polymorphic Cytochrome P450 2D6–Mediated Substrate. Journal of Pain & Palliative Care Pharmacotherapy 29:3, pages 272-275.
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