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Critical Care

External validation of the paracetamol-aminotransferase multiplication product to predict hepatotoxicity from paracetamol overdose

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Pages 807-814 | Received 11 May 2015, Accepted 22 Jun 2015, Published online: 15 Jul 2015

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Angela L. Chiew & Geoffrey K. Isbister. (2023) Advances in the understanding of acetaminophen toxicity mechanisms: a clinical toxicology perspective. Expert Opinion on Drug Metabolism & Toxicology 0:0, pages 1-16.
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Annabelle S Chidiac, Nicholas A Buckley, Firouzeh Noghrehchi & Rose Cairns. (2023) Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease. Expert Opinion on Drug Metabolism & Toxicology 19:5, pages 297-317.
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Chun En Yau, Haoyang Chen, Bryant Po-Yuen Lim, Mingwei Ng, R. Ponampalam, Daniel Yan Zheng Lim, Yip Han Chin & Andrew Fu Wah Ho. (2023) Performance of the paracetamol-aminotransferase multiplication product in risk stratification after paracetamol (acetaminophen) poisoning: a systematic review and meta-analysis. Clinical Toxicology 61:1, pages 1-11.
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Ari B. Filip, Sarah E. Berg, Michael E. Mullins & Evan S. Schwarz. (2022) Fomepizole as an adjunctive therapy for acetaminophen poisoning: cases reported to the toxicology investigators consortium (ToxIC) database 2015–2020. Clinical Toxicology 60:9, pages 1006-1011.
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Jacob A. Lebin & Anita Mudan. (2022) Comment on Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series. Clinical Toxicology 60:5, pages 665-665.
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Stephanie L. Link, Garrett Rampon, Stephen Osmon, Anthony J. Scalzo & Barry H. Rumack. (2022) Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series. Clinical Toxicology 60:4, pages 472-477.
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Yvonne Gloor, Domitille Schvartz & Caroline F.Samer. (2019) Old problem, new solutions: biomarker discovery for acetaminophen liver toxicity. Expert Opinion on Drug Metabolism & Toxicology 15:8, pages 659-669.
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Harry Egan, Geoffrey K. Isbister, Jennifer Robinson, Michael Downes, Betty S. Chan, Elia Vecellio & Angela L. Chiew. (2019) Retrospective evaluation of repeated supratherapeutic ingestion (RSTI) of paracetamol. Clinical Toxicology 57:8, pages 703-711.
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Anselm Wong, Natalie Homer, James W. Dear, Kay Weng Choy, James Doery & Andis Graudins. (2019) Paracetamol metabolite concentrations following low risk overdose treated with an abbreviated 12-h versus 20-h acetylcysteine infusion. Clinical Toxicology 57:5, pages 312-317.
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Anselm Wong, Marco L. A. Sivilotti, Naren Gunja, Richard McNulty & Andis Graudins. (2018) Accuracy of the paracetamol-aminotransferase product to predict hepatotoxicity in paracetamol overdose treated with a 2-bag acetylcysteine regimen. Clinical Toxicology 56:3, pages 182-188.
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Anselm Wong & Andis Graudins. (2017) Risk prediction of hepatotoxicity in paracetamol poisoning. Clinical Toxicology 55:8, pages 879-892.
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Anselm Wong, Marco L. A. Sivilotti & Andis Graudins. (2017) Accuracy of the paracetamol-aminotransferase multiplication product to predict hepatotoxicity in modified-release paracetamol overdose. Clinical Toxicology 55:5, pages 346-351.
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Morgan Riggan, Mireille Sayegh, Wayne Choi & Robert S. Hoffman. (2015) Letter in response to: External validation of the paracetamol-aminotransferase multiplication product to predict hepatotoxicity from paracetamol overdose. Clinical Toxicology 53:10, pages 1155-1156.
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Articles from other publishers (13)

Ari B. Filip & Michael E. Mullins. (2022) Fomepizole should be used more liberally in paracetamol overdose. British Journal of Clinical Pharmacology 89:2, pages 594-598.
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Ali Mohammad Pourbagher-Shahri, Jonathan Schimmel, Farshad M. Shirazi, Samaneh Nakhaee & Omid Mehrpour. (2022) Use of fomepizole (4-methylpyrazole) for acetaminophen poisoning: A scoping review. Toxicology Letters 355, pages 47-61.
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J-S Yen, C-C Hu, W-H Huang, C-W Hsu, T-H Yen & C-H Weng. (2021) An artificial intelligence algorithm for analyzing acetaminophen-associated toxic hepatitis. Human & Experimental Toxicology 40:11, pages 1947-1954.
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Angela L. Chiew & Nicholas A. Buckley. (2021) Acetaminophen Poisoning. Critical Care Clinics 37:3, pages 543-561.
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Richard L. Lambert. 2021. Pediatric Critical Care. Pediatric Critical Care 1289 1314 .
Angela L. Chiew, Laura P. James, Geoffrey K. Isbister, John W. Pickering, Kylie McArdle, Betty S.H. Chan & Nicholas A. Buckley. (2020) Early acetaminophen-protein adducts predict hepatotoxicity following overdose (ATOM-5). Journal of Hepatology 72:3, pages 450-462.
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Kartik R. Shah & Michael C. Beuhler. (2020) Fomepizole as an Adjunctive Treatment in Severe Acetaminophen Toxicity. The American Journal of Emergency Medicine 38:2, pages 410.e5-410.e6.
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Anselm Wong, Richard McNulty, David Taylor, Marco Sivilotti, Shaun Greene, Naren Gunja, Zeff Koutsogiannis & Andis Graudins. (2019) The NACSTOP Trial: A Multicenter, Cluster‐Controlled Trial of Early Cessation of Acetylcysteine in Acetaminophen Overdose. Hepatology 69:2, pages 774-784.
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Diego Castanares-Zapatero, Valérie Dinant, Ilaria Ruggiano, Harold Willem, Pierre-François Laterre & Philippe Hantson. (2018) Pattern of Paracetamol Poisoning: Influence on Outcome and Complications. Toxics 6:4, pages 58.
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B. Mégarbane. (2017) Intoxication par le paracétamol : quoi de neuf ?Acetaminophen poisoning: What is new?. Médecine Intensive Réanimation 26:5, pages 383-395.
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Anselm Wong, Cornelia Landersdorfer & Andis Graudins. (2017) Pharmacokinetic modelling of modified acetylcysteine infusion regimens used in the treatment of paracetamol poisoning. European Journal of Clinical Pharmacology 73:9, pages 1103-1110.
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Anselm Wong & Andis Graudins. (2016) N-acetylcysteine regimens for paracetamol overdose: Time for a change?. Emergency Medicine Australasia 28:6, pages 749-751.
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D Nicholas Bateman & Allister Vale. (2016) Paracetamol (acetaminophen). Medicine 44:3, pages 190-192.
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