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Clinical Toxicology Volume 53, 2015 - Issue 10
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RESEARCH ARTICLE

The pharmacokinetics and extracorporeal removal of N-acetylcysteine during renal replacement therapies

Stephanie H. HernandezDivision of Medical Toxicology, Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USACorrespondence[email protected]
,
Maryann HowlandSt. John’s University College of Pharmacy and Health Sciences, Queens, NY, USA;New York City Poison Control Center, New York City Department of Health, New York, NY, USA;Division of Medical Toxicology, Department of Emergency Medicine, New York University School of Medicine, New York, NY, USA
,
Thomas D. SchianoDivision of Liver Diseases, Department of Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA
&
Robert S. HoffmanNew York City Poison Control Center, New York City Department of Health, New York, NY, USA;Division of Medical Toxicology, Department of Emergency Medicine, New York University School of Medicine, New York, NY, USA
Pages 941-949 | Received 12 May 2015, Accepted 10 Sep 2015, Published online: 20 Oct 2015

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Kartik R. Shah & Michael C. Beuhler. (2022) Single bag high dose intravenous N-acetylcysteine associated with decreased hepatotoxicity compared to triple bag intravenous N-acetylcysteine in high-risk acetaminophen ingestions. Clinical Toxicology 60:4, pages 493-498.
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Robert G. Hendrickson. (2019) What is the most appropriate dose of N-acetylcysteine after massive acetaminophen overdose?. Clinical Toxicology 57:8, pages 686-691.
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Marc Ghannoum, Sara Kazim, Ami M. Grunbaum, Eric Villeneuve & Sophie Gosselin. (2016) Massive acetaminophen overdose: effect of hemodialysis on acetaminophen and acetylcysteine kinetics. Clinical Toxicology 54:6, pages 519-522.
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Articles from other publishers (12)

Laura Buisman, Ineke J. Riphagen, Marieke Kwant, Margo D. Themmen, Marjan Bouma & Carina Bethlehem. (2022) Case report: Salicylate intoxication can present with a normal anion gap metabolic acidosis depending on method used for measuring chloride. British Journal of Clinical Pharmacology 88:11, pages 4933-4936.
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Kersti Teder, Liivi Maddison, Hiie Soeorg, Andres Meos & Juri Karjagin. (2021) The Pharmacokinetic Profile and Bioavailability of Enteral N-Acetylcysteine in Intensive Care Unit. Medicina 57:11, pages 1218.
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Michael H. Chiu, Natalia Jaworska, Nicholas L. Li & Mark Yarema. (2021) Massive Acetaminophen Overdose Treated Successfully with N-Acetylcysteine, Fomepizole, and Hemodialysis. Case Reports in Critical Care 2021, pages 1-5.
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Angela L. Chiew & Nicholas A. Buckley. (2021) Acetaminophen Poisoning. Critical Care Clinics 37:3, pages 543-561.
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Puspraj Awasthi, Ankush Jindal, Yogish Sharma, Vijai Williams, Namita Ravikumar, Karthi Nallasamy & Suresh Kumar Angurana. (2020) Continuous Venovenous Hemofiltration as a Rescue Therapy for Severe Acetaminophen Toxicity in a Toddler. Journal of Pediatric Intensive Care 10:02, pages 159-161.
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Sean Cuninghame, Khaled Lotfy & Paul Cameron. (2021) Massive acetaminophen overdose with metabolic acidosis refractory to N-acetylcysteine, fomepizole, and renal replacement therapy. Toxicology Reports 8, pages 804-807.
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Stephen A. Harding, Rana Biary, Robert S. Hoffman, Mark K. Su & Mary Ann Howland. (2020) A Pharmacokinetic Analysis of Hemodialysis for Metformin-Associated Lactic Acidosis. Journal of Medical Toxicology.
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. 2019. Demystifying Drug Dosing in Renal Dysfunction. Demystifying Drug Dosing in Renal Dysfunction 189 200 .
Flaminia Coluzzi. (2018) Assessing and Treating Chronic Pain in Patients with End-Stage Renal Disease. Drugs 78:14, pages 1459-1479.
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Thomas M. Kitzler, Indra R. Gupta, Bradley Osterman, Chantal Poulin, Yannis Trakadis, Paula J. Waters & Daniela C. Buhas. 2019. JIMD Reports, Volume 45. JIMD Reports, Volume 45 57 63 .
B. Mégarbane. (2017) Intoxication par le paracétamol : quoi de neuf ?Acetaminophen poisoning: What is new?. Médecine Intensive Réanimation 26:5, pages 383-395.
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Humberto C. Gonzalez, Syed-Mohammed Jafri & Stuart C. Gordon. (2017) Management of Acute Hepatotoxicity Including Medical Agents and Liver Support Systems. Clinics in Liver Disease 21:1, pages 163-180.
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