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Letter to the Editor

Potential adjunct treatment for high-risk acetaminophen overdose

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Page 459 | Received 15 Dec 2015, Accepted 18 Jan 2016, Published online: 26 Feb 2016

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Ari B. Filip, Sarah E. Berg, Michael E. Mullins & Evan S. Schwarz. (2022) Fomepizole as an adjunctive therapy for acetaminophen poisoning: cases reported to the toxicology investigators consortium (ToxIC) database 2015–2020. Clinical Toxicology 60:9, pages 1006-1011.
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Michael E. Mullins, Lauren H. Yeager & William E. Freeman. (2020) Metabolic and mitochondrial treatments for severe paracetamol poisoning: a systematic review. Clinical Toxicology 58:12, pages 1284-1296.
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Jephte Y. Akakpo, Anup Ramachandran & Hartmut Jaeschke. (2020) Novel strategies for the treatment of acetaminophen hepatotoxicity. Expert Opinion on Drug Metabolism & Toxicology 16:11, pages 1039-1050.
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Mitchell R. McGill & Jack A. Hinson. (2020) The development and hepatotoxicity of acetaminophen: reviewing over a century of progress. Drug Metabolism Reviews 52:4, pages 472-500.
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Garrett Rampon, Haley Wartman, Stephen Osmon & Anthony Scalzo. (2020) Use of fomepizole as an adjunct in the treatment of acetaminophen overdose: a case series. Toxicology Communications 4:1, pages 1-4.
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Articles from other publishers (9)

Ari B. Filip & Michael E. Mullins. (2022) Fomepizole should be used more liberally in paracetamol overdose. British Journal of Clinical Pharmacology 89:2, pages 594-598.
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Matthew T. Stanton. (2022) Part II : Interactive case: Toxicology and poison control . JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY 5:12, pages 1332-1337.
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Ali Mohammad Pourbagher-Shahri, Jonathan Schimmel, Farshad M. Shirazi, Samaneh Nakhaee & Omid Mehrpour. (2022) Use of fomepizole (4-methylpyrazole) for acetaminophen poisoning: A scoping review. Toxicology Letters 355, pages 47-61.
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Jephte Y. Akakpo, Anup Ramachandran, Steven C. Curry, Barry H. Rumack & Hartmut Jaeschke. (2022) Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose. Archives of Toxicology 96:2, pages 453-465.
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Michael H. Chiu, Natalia Jaworska, Nicholas L. Li & Mark Yarema. (2021) Massive Acetaminophen Overdose Treated Successfully with N-Acetylcysteine, Fomepizole, and Hemodialysis. Case Reports in Critical Care 2021, pages 1-5.
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Hartmut Jaeschke, Jephte Y Akakpo, David S Umbaugh & Anup Ramachandran. (2020) Novel Therapeutic Approaches Against Acetaminophen-induced Liver Injury and Acute Liver Failure. Toxicological Sciences 174:2, pages 159-167.
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A. Min Kang, Angela Padilla-Jones, Erik S. Fisher, Jephte Y. Akakpo, Hartmut Jaeschke, Barry H. Rumack, Richard D. Gerkin & Steven C. Curry. (2019) The Effect of 4-Methylpyrazole on Oxidative Metabolism of Acetaminophen in Human Volunteers. Journal of Medical Toxicology 16:2, pages 169-176.
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Hartmut Jaeschke, Luqi Duan, Nga T. Nguyen & Anup Ramachandran. (2019) Mitochondrial damage and biogenesis in acetaminophen-induced liver injury. Liver Research 3:3-4, pages 150-156.
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Jephte Y Akakpo, Anup Ramachandran, Luqi Duan, Matthew A Schaich, Matthew W Jaeschke, Bret D Freudenthal, Wen-Xing Ding, Barry H Rumack & Hartmut Jaeschke. (2019) Delayed Treatment With 4-Methylpyrazole Protects Against Acetaminophen Hepatotoxicity in Mice by Inhibition of c-Jun n-Terminal Kinase. Toxicological Sciences 170:1, pages 57-68.
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