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Clinical Toxicology Volume 54, 2016 - Issue 6
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Basic Research

Diglycolic acid, the toxic metabolite of diethylene glycol, chelates calcium and produces renal mitochondrial dysfunction in vitro

Taylor ConradLouisiana State University Health School of Medicine-Shreveport, Shreveport, LA, USA; ;Department of Pharmacology, Toxicology, and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA, USA;
,
Greg M. LandryDepartment of Pharmacology, Toxicology, and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA, USA;
,
Tak Yee AwDepartment of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA, USA
,
Royce NicholsDepartment of Pharmacology, Toxicology, and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA, USA;
&
Kenneth E. McMartinDepartment of Pharmacology, Toxicology, and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA, USA; Correspondence[email protected]
Pages 501-511 | Received 01 Feb 2016, Accepted 29 Feb 2016, Published online: 22 Mar 2016

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Courtney N. Jamison, Robert D. Dayton, Brian Latimer, Mary P. McKinney, Hannah G. Mitchell & Kenneth E. McMartin. (2022) Diethylene glycol produces nephrotoxic and neurotoxic effects in female rats. Clinical Toxicology 60:3, pages 324-331.
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Courtney N. Jamison, Robert D. Dayton, Brian Latimer, Mary P. McKinney, Hannah G. Mitchell & Kenneth E. McMartin. (2021) Neurotoxic effects of nephrotoxic compound diethylene glycol. Clinical Toxicology 59:9, pages 810-821.
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Wendy Young & Lowri DeJager. (2018) Analysis of diglycolic acid in food packaging, over the counter products, direct additive carboxymethyl cellulose, and retail foods. Food Additives & Contaminants: Part A 35:12, pages 2309-2314.
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Corie N. Robinson, Brian Latimer, Fleurette Abreo, Kiera Broussard & Kenneth E. McMartin. (2017) In-vivo evidence of nephrotoxicity and altered hepatic function in rats following administration of diglycolic acid, a metabolite of diethylene glycol. Clinical Toxicology 55:3, pages 196-205.
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Articles from other publishers (15)

Finis L. Cavendar & Thomas H. Keenan. 2003. Patty's Toxicology. Patty's Toxicology 1 57 .
Stanley de Almeida Araújo, Bárbara Caroline Dias Faria, Júlia Cunha Vasconcelos, Aniel Feitosa da Cruz, Vitor Santos de Souza, David Campos Wanderley & Ana Cristina Simões-e-Silva. (2023) Renal toxicity caused by diethylene glycol: an overview. International Urology and Nephrology.
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Kristi J. Reed & Greg M. Landry. (2023) Diglycolic acid inhibits succinate dehydrogenase activity, depletes mitochondrial membrane potential, and induces inflammation in an SH-SY5Y neuroblastoma model of neurotoxicity in vitro. Toxicology and Applied Pharmacology 463, pages 116414.
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Julie D Tobin, Corie N Robinson, Elliot S Luttrell-Williams, Greg M Landry, Donard Dwyer & Kenneth E McMartin. (2022) Role of Plasma Membrane Dicarboxylate Transporters in the Uptake and Toxicity of Diglycolic Acid, a Metabolite of Diethylene Glycol, in Human Proximal Tubule Cells. Toxicological Sciences 190:1, pages 1-12.
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Jennifer A. Ross, Heather A. Borek, Christopher P. Holstege & Joshua D. King. (2022) Toxic Alcohol Poisoning. Emergency Medicine Clinics of North America 40:2, pages 327-341.
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Kristi J. Reed, Dylan T. Freeman & Greg M. Landry. (2021) Diethylene glycol and its metabolites induce cell death in SH-SY5Y neuronal cells in vitro. Toxicology in Vitro 75, pages 105196.
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Jennifer A. Ross, Heather A. Borek & Christopher P. Holstege. (2021) Toxic Alcohols. Critical Care Clinics 37:3, pages 643-656.
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Kirsten Eckstrum, Anneliese Striz, Martine Ferguson, Yang Zhao, Bonnie Welch, Nick Solomotis, Nicholas Olejnik & Robert Sprando. (2020) Utilization of a model hepatotoxic compound, diglycolic acid, to evaluate liver Organ-Chip performance and in vitro to in vivo concordance. Food and Chemical Toxicology 146, pages 111850.
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Krystal J. Godri Pollitt, Jae-Hong Kim, Jordan Peccia, Menachem Elimelech, Yawei Zhang, Georgia Charkoftaki, Brenna Hodges, Ines Zucker, Huang Huang, Nicole C. Deziel, Kara Murphy, Momoko Ishii, Caroline H. Johnson, Andrea Boissevain, Elaine O'Keefe, Paul T. Anastas, David Orlicky, David C. Thompson & Vasilis Vasiliou. (2019) 1,4-Dioxane as an emerging water contaminant: State of the science and evaluation of research needs. Science of The Total Environment 690, pages 853-866.
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Kenneth E. McMartin. 2018. Mitochondrial Biology and Experimental Therapeutics. Mitochondrial Biology and Experimental Therapeutics 193 211 .
Jeff Fowles, Marcy Banton, Joanna Klapacz & Hua Shen. (2017) A toxicological review of the ethylene glycol series: Commonalities and differences in toxicity and modes of action. Toxicology Letters 278, pages 66-83.
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William M. Snellings, Kenneth E. McMartin, Marcy I. Banton, Fred Reitman & Joanna Klapacz. (2017) Human health assessment for long-term oral ingestion of diethylene glycol. Regulatory Toxicology and Pharmacology 87, pages S1-S20.
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Richard Calvert, Miriam E Mossoba, Keenan Bailey, Howard Toomer, Sanah Vohra, Zachary Keltner, Vanessa Topping, Thomas Black, Nicholas Olejnik, Ana Depina, Kathleen Belgrave, Jessica Sprando, Paddy L Wiesenfeld & Robert L Sprando. (2017) Cardiotoxicity testing of diglycolic acid using In Vitro and In Vivo models. Journal of Toxicology and Health 4:1, pages 3.
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Miriam E. Mossoba, Sanah Vohra, Howard Toomer, Shelia Pugh-Bishop, Zachary Keltner, Vanessa Topping, Thomas Black, Nicholas Olejnik, Ana Depina, Kathleen Belgrave, Jessica Sprando, Joyce Njorge, Thomas J. Flynn, Paddy L. Wiesenfeld & Robert L. Sprando. (2017) Comparison of diglycolic acid exposure to human proximal tubule cells in vitro and rat kidneys in vivo. Toxicology Reports 4, pages 342-347.
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J. Rick Turner, Dilip R. Karnad & Snehal KothariJ. Rick Turner, Dilip R. Karnad & Snehal Kothari. 2017. Cardiovascular Safety in Drug Development and Therapeutic Use. Cardiovascular Safety in Drug Development and Therapeutic Use 3 20 .

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