Advanced search
Publication Cover
Clinical Toxicology Volume 7, 1974 - Issue 2
Journal homepage
35
Views
37
CrossRef citations to date
0
Altmetric
Research Article

Coniine, a Teratogenic Principle from Conium maculatum Producing Congenital Malformations in Calves

Richard F. Keeler U.S. Department Of Agriculture, Agricultural Research Service Western Region Poisonous Plant Research Laboratory, Logan, Utah
Pages 195-206 | Published online: 25 Sep 2008

Citations (37)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (5)

K. E. Panter, T. D. Bunch, R. F. Keeler, D.V. Sisson & R.J. Callan. (1990) Multiple congenital contractures (mcc) and cleft palate induced in goats by ingestion of piperidine alkaloid-containing plants: Reduction in fetal movement as the probable cause. Journal of Toxicology: Clinical Toxicology 28:1, pages 69-83.
Read now
K. E. Panter, T. D. Bunch, R. F. Keeler & D. V. Sisson. (1988) Radio ultrasound observations of the fetotoxic effects in sheep from ingestion of conium maculatum (poison-hemlock). Journal of Toxicology: Clinical Toxicology 26:3-4, pages 175-187.
Read now
Richard F. Keeler. (1979) Congenital Defects in Calves from Maternal Ingestion of Nicotiana glauca of High Anabasine Content. Clinical Toxicology 15:4, pages 417-426.
Read now
Richard F. Keeler & Lew Dell Balls. (1978) Teratogenic Effects in Cattle of Conium maculatum and Conium Alkaloids and Analogs. Clinical Toxicology 12:1, pages 49-64.
Read now
RichardF. Keeler. (1976) Lupin alkaloids from teratogenic and nonteratogenic lupins. III. Identification of anagyrine as the probable teratogen by feeding trials. Journal of Toxicology and Environmental Health 1:6, pages 887-898.
Read now

Articles from other publishers (32)

Paula Murphy & Rebecca A. Rolfe. 2023. Roles of Skeletal Muscle in Organ Development. Roles of Skeletal Muscle in Organ Development 81 110 .
Robert W. Coppock & Margitta M. Dziwenka. 2022. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology 1443 1460 .
José Jailson Lima Bezerra, Anderson Angel Vieira Pinheiro & Ricardo Barbosa Lucena. (2021) Phytochemistry and teratogenic potential of Mimosa tenuiflora (willd.) poir. (Fabaceae) in ruminants: A systematic review. Toxicon 195, pages 78-85.
Crossref
Nicola Bates. (2020) Spring poisoning hazards. Livestock 25:2, pages 78-85.
Crossref
Anthony P. Knight. 2017. Nutritional Management of Equine Diseases and Special Cases. Nutritional Management of Equine Diseases and Special Cases 119 188 .
Robert W. Coppock & Margitta M. Dziwenka. 2017. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology 1391 1408 .
Frederick W. Fiesseler & Richard D. Shih. 2017. Critical Care Toxicology. Critical Care Toxicology 2205 2211 .
Frederick W. Fiesseler & Richard D. Shih. 2016. Critical Care Toxicology. Critical Care Toxicology 1 7 .
Stephen T. Lee, Benedict T. Green, Kevin D. Welch, Glenn T. Jordan, Qian Zhang, Kip E. Panter, David Hughes, Cheng-Wei Tom Chang, James A. Pfister & Dale R. Gardner. (2013) Stereoselective Potencies and Relative Toxicities of γ-Coniceine and N -Methylconiine Enantiomers . Chemical Research in Toxicology 26:4, pages 616-621.
Crossref
Benedict T. Green, Stephen T. Lee, Kevin D. Welch, James A. Pfister & Kip E. Panter. (2013) Fetal Muscle-Type Nicotinic Acetylcholine Receptor Activation in TE-671 Cells and Inhibition of Fetal Movement in a Day 40 Pregnant Goat Model by Optical Isomers of the Piperidine Alkaloid Coniine. Journal of Pharmacology and Experimental Therapeutics 344:1, pages 295-307.
Crossref
George E. Burrows & Ronald J. Tyrl. 2012. Toxic Plants of North America. Toxic Plants of North America 53 80 .
Robert W. Coppock & Margitta M. Dziwenka. 2011. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology 1127 1137 .
Stephen T. Lee, Benedict T. Green, Kevin D. Welch, James A. Pfister & Kip E. Panter. (2008) Stereoselective Potencies and Relative Toxicities of Coniine Enantiomers. Chemical Research in Toxicology 21:10, pages 2061-2064.
Crossref
Stephen T. Lee, Dale R. Gardner, Cheng‐Wei Tom Chang, Kip E. Panter & Russell J. Molyneux. (2008) Separation and measurement of plant alkaloid enantiomers by RP‐HPLC analysis of their Fmoc‐Alanine analogs. Phytochemical Analysis 19:5, pages 395-402.
Crossref
Tom Reynolds. (2005) Hemlock alkaloids from Socrates to poison aloes. Phytochemistry 66:12, pages 1399-1406.
Crossref
J. Vetter. (2004) Poison hemlock (Conium maculatum L.). Food and Chemical Toxicology 42:9, pages 1373-1382.
Crossref
Lynn F. James, Kip E. Panter, William Gaffield & Russell J. Molyneux. (2004) Biomedical Applications of Poisonous Plant Research. Journal of Agricultural and Food Chemistry 52:11, pages 3211-3230.
Crossref
James Schardein. 2000. Chemically Induced Birth Defects, Third Edition. Chemically Induced Birth Defects, Third Edition 969 995 .
T.A López, M.S Cid & M.L Bianchini. (1999) Biochemistry of hemlock (Conium maculatum L.) alkaloids and their acute and chronic toxicity in livestock. A review. Toxicon 37:6, pages 841-865.
Crossref
Jeffrey Weinzweig, Kip E. Panter, Marcello Pantaloni, Anthony Spangenberger, James S. Harper, Felix Lui, Dale Gardner, Terrie L. Wierenga & Lee E. Edstrom. (1999) The Fetal Cleft Palate: I. Characterization of a Congenital Model. Plastic and Reconstructive Surgery 103:2, pages 419-428.
Crossref
Michael Wink. 1993. 1 118 .
R. Hänsel, K. Keller, H. Rimpler, G. Schneider, R. D. Aye, I. Bauer, T. W. Baumann, M. Beck, A. Beil, W. Blascheck, N. Brand, U. Braun-Sprakties, R. Brenneisen, A. Burger, R. Carle, N. Chaurasia, B. Diettrich, U. Eilert, W. Ferstl, M. Fett, G. Franck, B. Frank, B. Gehrmann, P. Gorecki, L. Gracza, S. Greiner, M. W. Grubert, S. Hampe, R. Hänsel, G. Harnischfeger, G. Henkler, A. Hensel, G. Heubl, A. Hiermann, K. Hiller, K. Hoffmann-Bohm, B. Hohmann, U. Hölscher, K.-H. Horz, O. Isaac, P. Junior, J. Jüptner, J. Jurenitsch, M. Kämpfer, T. Kartnig, F. Khaliefi, C. Kletter, M. Kober, H. P. Koch, H. Koehler, B. Kopp, J. Kraus, Lj. Kraus, W. Kreis, L. Langhammer, R. Liersch, U. Lindequist, D. Loew, M. Luckner, K. Mathys, I. Merfort, H. Miething, S. Moeck, S. Mundt, D. Paper, H. Pilgrim, P. Proksch, O. Ratka, H.-W. Rauwald, J. Reichling, C. Schennen, W. Schilz, H. Schleinitz, S. Schmidt, K. Schneider, E. Scholz, T. Schöpke, H. Schwarze, S. Schweins, B. Schwell, R. Seitz, C.-P. Siegers, P. Simon, U. Sonnenborn, V. Ssymank, K. Staesche, E. Stahl-Biskup, W. Steuding, H. Stuppner, E. Teuscher, H. Thober-Miething, B. Uehleke, M. Veit, D. Warncke, M. Wink, U. Wissinger-Gräfenhahn & B. Zepernick. 1992. Drogen A-D. Drogen A-D 595 1133 .
Larry S. Jeffery & Laren R. Robison. (2017) Poison-Hemlock ( Conium maculatum ) Control in Alfalfa ( Medicago sativa ) . Weed Technology 4:3, pages 585-587.
Crossref
K.E. Panter, R.F. Keeler, T.D. Bunch & R.J. Callan. (1990) Congenital skeletal malformations and cleft palate induced in goats by ingestion of Lupinus, Conium and Nicotiana species. Toxicon 28:12, pages 1377-1385.
Crossref
Richard F. Keeler & Kip E. Panter. (2005) Piperidine alkaloid composition and relation to crooked calf disease‐inducing potential of Lupinus formosus . Teratology 40:5, pages 423-432.
Crossref
R.A. Bellows, D.J. Patterson, P.J. Burfening & D.A. Phelps. (1987) Occurrence of neonatal and postnatal mortality in range beef cattle. II. Factors contributing to calf death. Theriogenology 28:5, pages 573-586.
Crossref
L. C. Abbott, R. H. Finnell, G. F. Chernoff, S. M. Parish & C. C. Gay. (2016) Crooked Calf Disease: A Histological and Histochemical Examination of Eight Affected Calves. Veterinary Pathology 23:6, pages 734-740.
Crossref
Richard F. Keeler, M. Ward Crowe & Edwin A. Lambert. (2005) Teratogenicity in swine of the tobacco alkaloid anabasine isolated from Nicotiana glauca . Teratology 30:1, pages 61-69.
Crossref
K.E. Panter, R.F. Keeler, W.B. Buck & J.L. Shupe. (1983) Toxicity and teratogenicity of in swine. Toxicon 21, pages 333-336.
Crossref
R. Ely & H. W. Lerpold. (2010) Arthrogryposis in Yorkshire piglets. Zeitschrift für Tierzüchtung und Züchtungsbiologie 96:1-4, pages 241-252.
Crossref
Lloyd A. Selby. 1978. Effects of Poisonous Plants on Livestock. Effects of Poisonous Plants on Livestock 441 450 .
Richard F. Keeler. 1978. Effects of Poisonous Plants on Livestock. Effects of Poisonous Plants on Livestock 397 408 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.