79
Views
70
CrossRef citations to date
0
Altmetric
Research Article

Effects of Chronic Organophosphate Pesticide Exposure on the Central Nervous System

&
Pages 83-95 | Published online: 25 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

María Teresa Muñoz-Quezada, Boris Andrés Lucero, Verónica Paz Iglesias, María Pía Muñoz, Claudia Alejandra Cornejo, Eduardo Achu, Brittney Baumert, Arianna Hanchey, Carlos Concha, Ana María Brito & Marcos Villalobos. (2016) Chronic exposure to organophosphate (OP) pesticides and neuropsychological functioning in farm workers: a review. International Journal of Occupational and Environmental Health 22:1, pages 68-79.
Read now
Sarah Mackenzie Ross, I. C. McManus, Virginia Harrison & Oliver Mason. (2013) Neurobehavioral problems following low-level exposure to organophosphate pesticides: a systematic and meta-analytic review. Critical Reviews in Toxicology 43:1, pages 21-44.
Read now
Suleiman Folorunsho Ambali & Joseph Olusegun Ayo. (2011) Sensorimotor performance deficits induced by chronic chlorpyrifos exposure in Wistar rats: mitigative effect of vitamin C. Toxicological & Environmental Chemistry 93:6, pages 1212-1226.
Read now
Richard Stephens & Balraj Sreenivasan. (2004) Neuropsychological Effects of Long-Term Low-Level Organophosphate Exposure in Orchard Sprayers in England. Archives of Environmental Health: An International Journal 59:11, pages 566-574.
Read now
John H. McDonough. (2002) Performance Impacts of Nerve Agents and Their Pharmacological Countermeasures. Military Psychology 14:2, pages 93-119.
Read now
David H. Moore. (1998) Health Effects of Exposure to Low Doses of Nerve Agent-a Review of Present Knowledge. Drug and Chemical Toxicology 21:sup1, pages 123-130.
Read now
Steven B. Markowitz. (1992) Poisoning of an urban family due to misapplication of household organophosphate and carbamate pesticides. Journal of Toxicology: Clinical Toxicology 30:2, pages 295-303.
Read now

Articles from other publishers (63)

Arushi Gupta, Anu Kumari, Neha Kaushal, Anas Saifi, Girish Mohanta, Abhay Sachdev, Kamlesh Kumar, Akash Deep & Avishek Saha. (2022) Recent Advances in the Applications of Carbon Nanostructures on Optical Sensing of Emerging Aquatic Pollutants. ChemNanoMat 8:6.
Crossref
Caterina Ledda, Emanuele Cannizzaro, Diana Cinà, Vera Filetti, Ermanno Vitale, Gianluca Paravizzini, Concettina Di Naso, Ivo Iavicoli & Venerando Rapisarda. (2021) Oxidative stress and DNA damage in agricultural workers after exposure to pesticides. Journal of Occupational Medicine and Toxicology 16:1.
Crossref
Chia-Huang Chang, Ching-Jung Yu, Jung-Chieh Du, Hsien-Chih Chiou, Jia-Woei Hou, Winnie Yang, Chian-Feng Chen, Hsin-Chang Chen, Ying-Sheue Chen, Betau Hwang & Mei-Lien Chen. (2021) The associations among organophosphate pesticide exposure, oxidative stress, and genetic polymorphisms of paraoxonases in children with attention deficit/hyperactivity disorder. Science of The Total Environment 773, pages 145604.
Crossref
Iqbal Ansari, Maha M. El-Kady, Charu Arora, Muniyan Sundararajan, Deblina Maiti & Aarif Khan. 2021. Global Climate Change. Global Climate Change 361 391 .
W. Kent Anger, Fayssal M. Farahat, Pamela J. Lein, Michael R. Lasarev, James R. Olson, Taghreed M. Farahat & Diane S. Rohlman. (2020) Magnitude of behavioral deficits varies with job-related chlorpyrifos exposure levels among Egyptian pesticide workers. NeuroToxicology 77, pages 216-230.
Crossref
Douglas Lopes Almeida, Audrei Pavanello, Lucas Paulo Saavedra, Tais Susane Pereira, Marialba Avezum Alves de Castro-Prado & Paulo Cezar de Freitas Mathias. (2019) Environmental monitoring and the developmental origins of health and disease. Journal of Developmental Origins of Health and Disease 10:6, pages 608-615.
Crossref
Rajesh Kumar Kori, Whidul Hasan, Abhishek Kumar Jain & Rajesh Singh Yadav. (2019) Cholinesterase inhibition and its association with hematological, biochemical and oxidative stress markers in chronic pesticide exposed agriculture workers. Journal of Biochemical and Molecular Toxicology 33:9.
Crossref
Sarah Mackenzie Ross, Chris McManus, Virginia Harrison & Oliver Mason. (2016) Reflections on the process of using systematic review techniques to evaluate the literature regarding the neurotoxicity of low level exposure to organophosphate pesticides. Environment International 92-93, pages 569-573.
Crossref
Monika Meyer-Baron, Guido Knapp, Michael Schäper & Christoph van Thriel. (2015) Meta-analysis on occupational exposure to pesticides – Neurobehavioral impact and dose–response relationships. Environmental Research 136, pages 234-245.
Crossref
N. Takahashi & M. Hashizume. (2014) A systematic review of the influence of occupational organophosphate pesticides exposure on neurological impairment. BMJ Open 4:6, pages e004798-e004798.
Crossref
Michael D. Coleman. 2014. Expert Report Writing in Toxicology. Expert Report Writing in Toxicology 123 178 .
Kevin Woodward & Kevin WoodwardTimothy C. Marrs. 2012. Toxicological Effects of Veterinary Medicinal Products in Humans. Toxicological Effects of Veterinary Medicinal Products in Humans 33 70 .
Monika Meyer-Baron, Eun A. Kim, Iman Nuwayhid, Gaku Ichihara & Seong-Kyu Kang. (2012) Occupational exposure to neurotoxic substances in Asian countries – Challenges and approaches. NeuroToxicology 33:4, pages 853-861.
Crossref
Diane S. Rohlman, W. Kent Anger & Pamela J. Lein. (2011) Correlating neurobehavioral performance with biomarkers of organophosphorous pesticide exposure. NeuroToxicology 32:2, pages 268-276.
Crossref
D. Cardona, G. López-Crespo, M. C. Sánchez-Amate, P. Flores & F. Sánchez-Santed. (2010) Impulsivity as Long-Term Sequelae After Chlorpyrifos Intoxication: Time Course and Individual Differences. Neurotoxicity Research 19:1, pages 128-137.
Crossref
S. Little, H. Llewellyn & SFJ Clarke. (2010) Sensory ataxia associated with chronic organophosphate pesticide exposure. Human & Experimental Toxicology 29:8, pages 689-693.
Crossref
Fayssal M. Farahat, Richard A. Fenske, James R. Olson, Kit Galvin, Matthew R. Bonner, Diane S. Rohlman, Taghreed M. Farahat, Pamela J. Lein & W. Kent Anger. (2010) Chlorpyrifos exposures in Egyptian cotton field workers. NeuroToxicology 31:3, pages 297-304.
Crossref
Marcello Lotti. 2010. Hayes' Handbook of Pesticide Toxicology. Hayes' Handbook of Pesticide Toxicology 1543 1589 .
Ian C. Dewhurst & Timothy C. Marrs. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
Pedro A. Geraldi, JosÉ M. Delgado-GarcÍA & AgnÉS Gruart. (2008) Acute and repeated effects of three organophosphorus pesticides on the acquisition and retention of an instrumental learning task in rats. Neurotoxicity Research 13:3-4, pages 253-263.
Crossref
John McDonough & James Romano Jr.. 2007. Chemical Warfare Agents. Chemical Warfare Agents.
D. Cardona, M. López-Grancha, G. López-Crespo, F. Nieto-Escamez, F. Sánchez-Santed & P. Flores. (2006) Vulnerability of long-term neurotoxicity of chlorpyrifos: effect on schedule-induced polydipsia and a delay discounting task. Psychopharmacology 189:1, pages 47-57.
Crossref
Linda A. McCauley, W. Kent Anger, Matthew Keifer, Rick Langley, Mark G. Robson & Diane Rohlman. (2006) Studying Health Outcomes in Farmworker Populations Exposed to Pesticides. Environmental Health Perspectives 114:6, pages 953-960.
Crossref
Robin Whyatt, Natalie Freeman, Richard Wang, Brenda Eskenazi, Dana Barr, Luke Naeher & Asa Bradman. 2006. Human Developmental Neurotoxicology. Human Developmental Neurotoxicology 253 285 .
Freya Kamel & Jane A. Hoppin. (2004) Association of Pesticide Exposure with Neurologic Dysfunction and Disease. Environmental Health Perspectives 112:9, pages 950-958.
Crossref
Tangeng Ma, Robert E. Kramer, Rodney C. Baker, Lir‐Wan Fan & Ing K. Ho. (2002) Effects of chronic dermal exposure to nonlethal doses of methyl parathion on brain regional acetylcholinesterase and muscarinic cholinergic receptors in female rats. Journal of Neuroscience Research 71:1, pages 138-145.
Crossref
Goran A Jamal, Stig Hansen & Peter O.O Julu. (2002) Low level exposures to organophosphorus esters may cause neurotoxicity. Toxicology 181-182, pages 23-33.
Crossref
Marcello Lotti. (2002) Low-level exposures to organophosphorus esters and peripheral nerve function. Muscle & Nerve 25:4, pages 492-504.
Crossref
Robert B Dick, Kyle Steenland, Edward F KriegJr.Jr. & Cynthia J Hines. (2001) Evaluation of acute sensory–motor effects and test sensitivity using termiticide workers exposed to chlorpyrifos. Neurotoxicology and Teratology 23:4, pages 381-393.
Crossref
Marcello Lotti. 2001. Handbook of Pesticide Toxicology. Handbook of Pesticide Toxicology 1043 1085 .
James Romano & James King. 2000. Chemical Warfare Agents. Chemical Warfare Agents.
A.K Srivastava, B.N Gupta, V Bihari, N Mathur, L.P Srivastava, B.S Pangtey, R.S Bharti & P Kumar. (2000) Clinical, biochemical and neurobehavioural studies of workers engaged in the manufacture of quinalphos. Food and Chemical Toxicology 38:1, pages 65-69.
Crossref
Olav Axelson. 2000. Epidemiology of Work Related Diseases. Epidemiology of Work Related Diseases 195 214 .
David E Ray. (1998) Chronic effects of low level exposure to anticholinesterases — a mechanistic review. Toxicology Letters 102-103, pages 527-533.
Crossref
David H. Moore. (1998) Long term health effects of low dose exposure to nerve agent. Journal of Physiology-Paris 92:3-4, pages 325-328.
Crossref
Richard Stephens, Anne Spurgeon & Helen Berry. (1996) Organophosphates: The relationship between chronic and acute exposure effects. Neurotoxicology and Teratology 18:4, pages 449-453.
Crossref
G. David Young & Irwin Koplovitz. (1995) Acute toxicity of cyclohexylmethylphosphonofluoridate (CMPF) in rhesus monkeys: serum biochemical and hematologic changes. Archives of Toxicology 69:6, pages 379-383.
Crossref
Jack Mearns, John Dunn & Paul R. Lees-Haley. (1994) Psychological effects of organophosphate pesticides: A review and call for research by psychologists. Journal of Clinical Psychology 50:2, pages 286-294.
Crossref
Robert M. AndersonJr.Jr.Robert M. AndersonJr.Jr.. 1994. Practitioner’s Guide to Clinical Neuropsychology. Practitioner’s Guide to Clinical Neuropsychology 336 344 .
Timothy C. Marrs. (1993) Organophosphate poisoning. Pharmacology & Therapeutics 58:1, pages 51-66.
Crossref
William Daniell, Scott Barnhart, Paul Demers, Lucio G. Costa, David L. Eaton, Mary Miller & Linda Rosenstock. (1992) Neuropsychological performance among agricultural pesticide applicators. Environmental Research 59:1, pages 217-228.
Crossref
U.K. Misra. 1992. Clinical and Experimental Toxicology of Organophosphates and Carbamates. Clinical and Experimental Toxicology of Organophosphates and Carbamates 446 459 .
Marcello Lotti. 1992. Clinical and Experimental Toxicology of Organophosphates and Carbamates. Clinical and Experimental Toxicology of Organophosphates and Carbamates 75 83 .
David E. Hartman, Stephen Hessl & Alyce Bezman Tarcher. 1992. Principles and Practice of Environmental Medicine. Principles and Practice of Environmental Medicine 241 262 .
Sakari A. Nieminen, Anne Lecklin, Outi Heikkinen & Pauli Ylitalo. (1990) Acute Behavioural Effects of the Organophosphates Sarin and Soman in Rats. Pharmacology & Toxicology 67:1, pages 36-40.
Crossref
Linda Rosenstock, William Daniell, Scott Barnhart, David Schwartz & Paul A. Demers. (2007) Chronic neuropsychological sequelae of occupational exposure to organophosphate insecticides. American Journal of Industrial Medicine 18:3, pages 321-325.
Crossref
Brenda Eskenazi & Neil A. Maizlish. 1988. Medical Neuropsychology. Medical Neuropsychology 223 264 .
Lucio G. Costa. 1988. Recent Advances in Nervous System Toxicology. Recent Advances in Nervous System Toxicology 203 246 .
J. F. Glenn, D. J. Hinman & S. B. McMaster. 1987. Neurobiology of Acetylcholine. Neurobiology of Acetylcholine 503 534 .
Neil Maizlish, Marc Schenker, Carol Weisskopf, James Seiber & Steven Samuels. (2007) A behavioral evaluation of pest control workers with short‐term, low‐level exposure to the organophosphate diazinon. American Journal of Industrial Medicine 12:2, pages 153-172.
Crossref
James J. Valdes, Tsung-Ming Shih & Christopher Whalley. (1985) Soman intoxication alters regional brain muscarinic and GABA receptors. Pesticide Biochemistry and Physiology 24:3, pages 355-361.
Crossref
James J. Valdes, Nancy A. Chester, Darrel Menking, Tsung-Ming Shih & Christopher Whalley. (1985) Regional sensitivity of neuroleptic receptors to sub-acute soman intoxication. Brain Research Bulletin 14:2, pages 117-121.
Crossref
Jörg-M. Chemnitius, Karl-H. Haselmeyer & Ronald Zech. (1983) Brain cholinesterases. Biochemical Pharmacology 32:11, pages 1693-1699.
Crossref
Alvin M. Revzin. 1983. Mode of Action, Metabolism and Toxicology. Mode of Action, Metabolism and Toxicology 419 424 .
G. Lemercier, P. Carpentier, H. Sentenac-Roumanou & P. Morelis. (1983) Histological and histochemical changes in the central nervous system of the rat poisoned by an irreversible anticholinesterase organophosphorus compound. Acta Neuropathologica 61:2, pages 123-129.
Crossref
Lucio G. Costa & Sheldon D. Murphy. (1982) Passive avoidance retention in mice tolerant to the organophosphorus insecticide disulfoton. Toxicology and Applied Pharmacology 65:3, pages 451-458.
Crossref
Lucio G. Costa, Bradley W. Schwab & Sheldon D. Murphy. (1982) Tolerance to anticholinesterase compounds in mammals. Toxicology 25:2-3, pages 79-97.
Crossref
William J. Popendorf & John T. Leffingwell. 1982. Residue Reviews. Residue Reviews 125 201 .
D. Maślińska, I. Lewandowska & J. Prokopczyk. 1981. Experimental and Clinical Neuropathology. Experimental and Clinical Neuropathology 52 55 .
Yaacov Ben-Barak, Herbert Gazit & Yadin Dudai. (1980) Fornix lesion prevents an organophosphate-induced decrease in muscarinic receptor level in rat hippocampus. Brain Research 194:1, pages 240-243.
Crossref
Howard W. Klemmer, Lyle Wong, Miles M. Sato, Erida L. Reichert, Richard J. Korsak & M. Nabil Rashad. (1980) Clinical findings in workers exposed to pentachlorophenol. Archives of Environmental Contamination and Toxicology 9:6, pages 715-725.
Crossref
Herbert Gazit, Israel Silman & Yadin Dudai. (1979) Administration of an organophosphate causes a decrease in muscarinic receptor levels in rat brain. Brain Research 174:2, pages 351-356.
Crossref
A. G. Karczmar. 1979. Brain Acetylcholine and Neuropsychiatric Disease. Brain Acetylcholine and Neuropsychiatric Disease 265 310 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.