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Research Article

Chloroprene (2-chloro-1, 3-butadiene) — What is the Evidence for Its Carcinogenicity?

Pages 153-170 | Published online: 25 Sep 2008

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H. J. Clewell$suffix/text()$suffix/text(), J. L. Campbell, C. Van Landingham, A. Franzen, M. Yoon, D. E. Dodd, M. E. Andersen & P. R. Gentry. (2020) Response to “letter concerning: Clewell (2019) incorporation of in vitro metabolism data and physiologically based pharmacokinetic modeling in a risk assessment for chloroprene.” (UIHT-2020-0053). Inhalation Toxicology 32:9-10, pages 369-371.
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Harvey J. Clewell$suffix/text()$suffix/text(), Jerry L. Campbell, Cynthia Van Landingham, Allison Franzen, Miyoung Yoon, Darol E. Dodd, Melvin E. Andersen & P. Robinan Gentry. (2019) Incorporation of in vitro metabolism data and physiologically based pharmacokinetic modeling in a risk assessment for chloroprene. Inhalation Toxicology 31:13-14, pages 468-483.
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Articles from other publishers (11)

Fiorella Belpoggi, D. Chiozzotto & M. Lauriola. 2001. Patty's Toxicology. Patty's Toxicology 129 229 .
Ines Pagan. (2007) Chloroprene: Overview of studies under consideration for the development of an IRIS assessment. Chemico-Biological Interactions 166:1-3, pages 341-351.
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R. A. Lemen. 2001. Patty's Toxicology. Patty's Toxicology.
Rudolph Valentine & Matthew W Himmelstein. (2001) Overview of the acute, subchronic, reproductive, developmental and genetic toxicology of β-chloroprene. Chemico-Biological Interactions 135-136, pages 81-100.
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Matthew W Himmelstein, Steven C Carpenter, Paul M Hinderliter, Timothy A Snow & Rudolph Valentine. (2001) The metabolism of β-chloroprene: preliminary in-vitro studies using liver microsomes. Chemico-Biological Interactions 135-136, pages 267-284.
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Ronald L. Melnick, Robert C. Sills, Christopher J. Portier, Joseph H. Roycroft, Billy J. Chou, Sondra L. Grumbein & Rodney A. Miller. (1999) Multiple organ carcinogenicity of inhaled chloroprene (2-chloro-1,3-butadiene) in F344/N rats and B6C3F1 mice and comparison of dose–response with 1,3-butadiene in mice. Carcinogenesis 20:5, pages 867-878.
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Ronald L. Melnick, Michael R. Elwell, Joseph H. Roycroft, Billy J. Chou, Harvey A. Ragan & Rodney A. Miller. (1996) Toxicity of inhaled chloroprene (2-chloro-1,3-butadiene) in F344 rats and B6C3F1 mice. Toxicology 108:1-2, pages 79-91.
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F. Poncelet, M. Duverger-van Bogaert, M. Lambotte-Vandepaer & C. de Meester. 1984. Mutagenicity, Carcinogenicity, and Teratogenicity of Industrial Pollutants. Mutagenicity, Carcinogenicity, and Teratogenicity of Industrial Pollutants 205 279 .
U.H. Ehling, D. Averbeck, P.A. Cerutti, J. Friedman, H. Greim, A.C. KolbyeJr.Jr. & M.L. Mendelsohn. (1983) Review of the evidence for the presence or absence of thresholds in the induction of genetic effects by genotoxic chemicals. Mutation Research/Reviews in Genetic Toxicology 123:3, pages 281-341.
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Charles Veys. 1982. Current Approaches to Occupational Health. Current Approaches to Occupational Health 1 29 .
Karl-Heinz Summer & Helmut Greim. (1980) Detoxification of chloroprene (2-chloro-1,3-butadiene) with glutathione in the rat. Biochemical and Biophysical Research Communications 96:2, pages 566-573.
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