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Clinical Toxicology Volume 13, 1978 - Issue 2
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Research Article

Ethylene and Diethylene Glycol Toxicity

C. L. Winek Department of Pharmacology and Toxicology, Duquesne University School of Pharmacy, Pittsburgh, Pennsylvania, 15219
,
D. P. Shingleton Department of Pharmacology and Toxicology, Duquesne University School of Pharmacy, Pittsburgh, Pennsylvania, 15219
&
S. P. Shanor Department of Pharmacology and Toxicology, Duquesne University School of Pharmacy, Pittsburgh, Pennsylvania, 15219
Pages 297-324 | Published online: 25 Sep 2008

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J. G. Schier, D. R. Hunt, A. Perala, K. E. McMartin, M. J. Bartels, L. S. Lewis, M. A. McGeehin & W. D. Flanders. (2013) Characterizing concentrations of diethylene glycol and suspected metabolites in human serum, urine, and cerebrospinal fluid samples from the Panama DEG mass poisoning. Clinical Toxicology 51:10, pages 923-929.
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Leo J. Schep, Robin J. Slaughter, Wayne A. Temple & D. Michael G. Beasley. (2009) Diethylene glycol poisoning. Clinical Toxicology 47:6, pages 525-535.
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Anthony J. Scalzo. (1996) Diethylene Glycol Toxicity Revisited: The 1996 Haitian Epidemic. Journal of Toxicology: Clinical Toxicology 34:5, pages 513-516.
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Paul W. Baker, Allan M. Rofe, Renze Bais & V. Walker. (1996) Idiopathic Calcium Oxalate Urolithiasis and Endogenous Oxalate Production. Critical Reviews in Clinical Laboratory Sciences 33:1, pages 39-82.
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Abdulla I. Sabeel, Jan Kurkus & Tore Lindholm. (1995) Intensified Dialysis Treatment of Ethylene Glycol Intoxication. Scandinavian Journal of Urology and Nephrology 29:2, pages 125-129.
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HassanY. Aboul‐Enein & M. Rafiqul Islam. (1989) High performance liquid chromatography determination of ethylene glycol in stamp pad ink. Toxicological & Environmental Chemistry 24:3, pages 181-184.
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Werner Lenk, Doris Löhr & Johann Sonnenbichler. (1989) Pharmacokinetics and biotransformation of diethylene glycol and ethylene glycol in the rat. Xenobiotica 19:9, pages 961-979.
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Tracy P. Hewlett, Kenneth E. McMartin, Alert J. Lauro & Francis Avery Ragan. (1986) Ethylene Glycol Poisoning. The Value of Glycolic Acid Determinations for Diagnosis and Treatment. Journal of Toxicology: Clinical Toxicology 24:5, pages 389-402.
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W. Godolphin, E. P. Meagher, H. D. Sanders & J. Frohlich. (1980) Unusual Calcium Oxalate Crystals in Ethylene Glycol Poisoning. Clinical Toxicology 16:4, pages 479-486.
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Articles from other publishers (60)

Nicola Bates. (2023) Winter poisoning hazards for pets. Companion Animal 28:1, pages 1-9.
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Nicola Bates. (2022) Winter poisoning hazards for pets. The Veterinary Nurse 13:10, pages 461-470.
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Shikuan Shao, Xiangyu Zhu, Victoria Ten, Moon J. Kim & Xiaohu Xia. (2022) Understanding the Impact of Wall Thickness on Thermal Stability of Silver–Gold Nanocages. The Journal of Physical Chemistry C 126:16, pages 7337-7345.
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Nicola Bates. (2021) Poisons affecting the kidney. Companion Animal 26:4, pages 1-7.
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Daniel Wittschieber, Katrin Heuberger, Ronald Schulz, Helga Köhler & Karin Varchmin-Schultheiß. (2019) Fatal poisoning with diethylene glycol in an unusual setting. Forensic Science, Medicine and Pathology 15:4, pages 649-652.
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Nicola Bates. (2019) Poisons affecting the kidney. The Veterinary Nurse 10:8, pages 418-424.
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Ajoke F. Idayat Apanpa-Qasim & Adebola A. Adeyi. (2018) Oxygenated Volatile Organic Compounds (Anti-freezing Agents) in Decorative Water-based Paints Marketed in Nigeria. Journal of Health and Pollution 8:18.
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Nicola Bates. (2016) Ethylene glycol poisoning. Companion Animal 21:2, pages 95-99.
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N. Bates, P. Rawson-Harris & N. Edwards. (2015) Common questions in veterinary toxicology. Journal of Small Animal Practice 56:5, pages 298-306.
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Kelly W. Hall. 2015. Hamilton & Hardy's Industrial Toxicology. Hamilton & Hardy's Industrial Toxicology 419 444 .
Greg M. Landry, Cody L. Dunning, Fleurette Abreo, Brian Latimer, Elysse Orchard & Kenneth E. McMartin. (2015) Diethylene glycol-induced toxicities show marked threshold dose response in rats. Toxicology and Applied Pharmacology 282:3, pages 244-251.
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Randy L. Self. (2013) Direct analysis in real time-mass spectrometry (DART-MS) for rapid qualitative screening of toxic glycols in glycerin-containing products. Journal of Pharmaceutical and Biomedical Analysis 80, pages 155-158.
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Karyn Bischoff & Motoko Mukai. 2013. Small Animal Toxicology. Small Animal Toxicology 543 546 .
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 74 90 .
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 18 .
. 2002. The MAK-Collection for Occupational Health and Safety. The MAK-Collection for Occupational Health and Safety 74 100 .
. 2002. The MAK-Collection for Occupational Health and Safety. The MAK-Collection for Occupational Health and Safety 1 318 .
H. M. Bolt. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 106 121 .
H. M. Bolt. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 20 .
H.M. Bolt. 2002. The MAK-Collection for Occupational Health and Safety. The MAK-Collection for Occupational Health and Safety 1 8 .
Lauren M. Besenhofer, Patrick A. Adegboyega, Michael Bartels, Mark J. Filary, Adam W. Perala, Marie C. McLaren & Kenneth E. McMartin. (2010) Inhibition of Metabolism of Diethylene Glycol Prevents Target Organ Toxicity in Rats. Toxicological Sciences 117:1, pages 25-35.
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Lois J. ArendTibor Nadasdy. (2009) Emerging Therapy-Related Kidney Disease. Archives of Pathology & Laboratory Medicine 133:2, pages 268-278.
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Kenneth Scott Whitlow & Kyle J. Gunnerson. 2009. Critical Care Nephrology. Critical Care Nephrology 672 677 .
Josh Schier, Laura Conklin, Raquel Sabogal, Damon Dell’Aglio, Carlos Sanchez & James Sejvar. (2008) Medical toxicology and public health—Update on research and activities at the centers for disease control and prevention and the agency for toxic substances and disease registry. Journal of Medical Toxicology 4:1, pages 40-42.
Crossref
Bing-Liang Lin, Zhi-Xin Zhao, Yu-Tian Chong, Jian-Guo Li, Xing Zuo, Yu Tao, Tan-Qi Lou & Zhi-Liang Gao. (2008) Venous diethylene glycol poisoning in patients with preexisting severe liver disease in China. World Journal of Gastroenterology 14:20, pages 3236.
Crossref
Jeffrey A. Kraut & Ira Kurtz. (2008) Toxic Alcohol Ingestions: Clinical Features, Diagnosis, and Management. Clinical Journal of the American Society of Nephrology 3:1, pages 208-225.
Crossref
Karyn Bischoff. 2006. Small Animal Toxicology. Small Animal Toxicology 693 697 .
Bryan Ballantyne & William M. Snellings. (2005) Developmental toxicity study with diethylene glycol dosed by gavage to CD rats and CD-1 mice. Food and Chemical Toxicology 43:11, pages 1637-1646.
Crossref
Robert Hess, Michael J. Bartels & Lynn H. Pottenger. (2004) Ethylene glycol: an estimate of tolerable levels of exposure based on a review of animal and human data. Archives of Toxicology 78:12, pages 671-680.
Crossref
Marco L.A. Sivilotti, Michael J. Burns, Kenneth E. McMartin & Jeffrey Brent. (2000) Toxicokinetics of ethylene glycol during fomepizole therapy: Implications for management. Annals of Emergency Medicine 36:2, pages 114-125.
Crossref
Patrick D. Brophy, Milton Tenenbein, John Gardner, Timothy E. Bunchman & William E. Smoyer. (2000) Childhood diethylene glycol poisoning treated with alcohol dehydrogenase inhibitor fomepizole and hemodialysis. American Journal of Kidney Diseases 35:5, pages 958-962.
Crossref
John T. Barber, Dana A. Thomas, Lawrence Y. Yatsu & Harry E. Ensley. (1999) The physiological consequences of ethylene glycol-induced changes in the frond structure of Lemna gibba. Aquatic Toxicology 45:4, pages 253-264.
Crossref
. 1999. Toxicological Evaluations. Toxicological Evaluations 139 261 .
L. Schladt, I. Ivens, E. Karbe, C. Rühl-Fehlert & E. Bomhard. (1998) Subacute oral toxicity of tetraethylene glycol and ethylene glycoladministered to Wistar rats. Experimental and Toxicologic Pathology 50:3, pages 257-265.
Crossref
Henryk Giermaziak & Dariusz Tosik. (1996) Morphometric studies of the hepatocyte mitochondria and endoplasmic reticulum after acute ethylene glycol poisoning. Experimental and Toxicologic Pathology 48:4, pages 265-268.
Crossref
D. Jacobsen & K.E. McMartin. 1996. Human Toxicology. Human Toxicology 623 648 .
Edward W. Carney, Ashley B. Liberacki, Michael J. Bartels & William J. Breslin. (1996) Identification of proximate toxicant for ethylene glycol developmental toxicity using rat whole embryo culture. Teratology 53:1, pages 38-46.
Crossref
Gerhard Bringmann, Christiana Hesselmann & Doris Feineis. (1995) Endogenous alkaloids in man XXI. Analysis of glyoxylate-derived 1,3-thiazolidines and their precursors after trimethylsilylation by gas chromatography-mass spectrometry. Journal of Chromatography A 707:2, pages 267-281.
Crossref
Russell B. Rayman. 1995. Occupational Health in Aviation. Occupational Health in Aviation 117 165 .
Edward W. Carney. (1994) An integrated perspective on the developmental toxicity of ethylene glycol. Reproductive Toxicology 8:2, pages 99-113.
Crossref
Dorothea E. Blandford & Paul R. Desjardins. (1994) A rapid method for measurement of ethylene glycol. Clinical Biochemistry 27:1, pages 25-30.
Crossref
R. Heilmair, W. Lenk & D. Löhr. (1993) Toxicokinetics of diethylene glycol (DEG) in the rat. Archives of Toxicology 67:10, pages 655-666.
Crossref
László BurisLászló Buris. 1993. Forensic Medicine. Forensic Medicine 313 372 .
Gerhard Bringmann, Christiana Hesselmann & Doris Feineis. (1992) Endogenous alkaloids in man. Journal of Chromatography A 595:1-2, pages 351-354.
Crossref
Gerhard Bringmann, Doris Feineis, Christiana Hesselmann, Stephan Schneider, M. Koob & D. Henschler. (1992) A “chemical” concept for the therapy of glyoxylate-induced oxalurias (1). Life Sciences 50:21, pages 1597-1605.
Crossref
K. S. Khera. (2005) Chemically induced alterations in maternal homeostasis and histology of conceptus: Their etiologic significance in rat fetal anomalies. Teratology 44:3, pages 259-297.
Crossref
H. Kraul, F. Jahn & H. Bräunlich. (1991) Nephrotoxic effects of diethylene glycol (DEG) in rats. Experimental pathology 42:1, pages 27-32.
Crossref
D. P. Agarwal & H. W. Goedde. 1991. Ecogenetics. Ecogenetics 141 158 .
. 1990. Toxicological Evaluations. Toxicological Evaluations 217 249 .
K. J. Freundt & N. Weis. (1989) Transient renal impairment in rats after oral exposure to diethylene glycol. Journal of Applied Toxicology 9:5, pages 317-321.
Crossref
Claudio Giachetti, Giovanni Zanolo, Alessandro Assandri & Paolo Poletti. (1989) Determination of cyclic butylboronate esters of some 1,2- and 2,3-diols in plasma by high-resolution gas chromatography/mass spectrometry. Biological Mass Spectrometry 18:8, pages 592-597.
Crossref
Harvey L. Wiener & Keith E. Richardson. (1989) Metabolism of diethylene glycol in male rats. Biochemical Pharmacology 38:3, pages 539-541.
Crossref
Marie Balíková *Jiří Kohlíček. (1988) Rapid determination of ethylene glycol at toxic levels in serum and urine. Journal of Chromatography B: Biomedical Sciences and Applications 434:2, pages 469-474.
Crossref
Hans Maurer & Christine Kessler. (1988) Identification and quantification of ethylene glycol and diethylene glycol in plasma using gas chromatography-mass spectrometry. Archives of Toxicology 62:1, pages 66-69.
Crossref
R J Flanagan, S Dawling & B M Buckley. (2016) Measurement of Ethylene Glycol (Ethane-1,2-Diol) in Biological Specimens Using Derivatisation and Gas-Liquid Chromatography with Flame Ionisation Detection. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 24:1, pages 80-84.
Crossref
A.M. Rofe, R. Bais & R.A.J. Conyers. (1986) The effect of dietary refined sugars and sugar alcohols on renal calcium oxalate deposition in ethylene glycol-treated rats. Food and Chemical Toxicology 24:5, pages 397-403.
Crossref
Elliott Simpson. (2016) Some Aspects of Calcium Metabolism in a Fatal Case of Ethylene Glycol Poisoning. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 22:1, pages 90-93.
Crossref
YIN-TAK WOO, DAVID Y. LAI, JOSEPH C. ARCOS & MARY F. ARGUS. 1985. Aliphatic and Polyhalogenated Carcinogens. Aliphatic and Polyhalogenated Carcinogens 3 414 .
Dag Jacobsen, Nils Østby & Jan Erik Bredesen. (2009) Studies on Ethylene Glycol Poisoning. Acta Medica Scandinavica 212:1-2, pages 11-16.
Crossref
Maciej Bogusz. (1980) Vitreous humour as reliable material for ethylene glycol determination. Forensic Science International 16:1, pages 75-76.
Crossref

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